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Kuphatikiza kwa kuthekera kwa Prime Editing Platform yolengezedwa ndi Prime Medicine

Written by Harry Johnson

Prime Medicine, Inc., kampani yomwe idakhazikitsidwa kuti ipereke malonjezo a Prime Editing, lero yalengeza kuwonjezera kwamphamvu papulatifomu yake kutengera kafukufuku waposachedwa wasayansi.

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Prime Medicine, Inc., kampani yomwe idakhazikitsidwa kuti ipereke malonjezo a Prime Editing, lero yalengeza kuwonjezera kwamphamvu papulatifomu yake kutengera kafukufuku waposachedwa wasayansi.

Keith Gottesdiener, MD, CEO wa Prime Medicine anati: "Ndife okondwa kwambiri kuwona zinthu zikusintha zomwe zikuwonjezera kuthekera kwa Prime Editing ngati njira yothandizira." "Kupititsa patsogolo kumeneku, pamwamba paukadaulo woyambira maziko, kutero kudzawonjezera mphamvu ya Prime Editing, ndipo kudzawonjezera madera omwe Prime Editing ingagwire ntchito, zomwe zitha kufikitsa kufikira kwathu ku matenda enanso omwe sanakonzekebe kusintha kwa majini kukalankhula. ”

Ndi kupita patsogolo kumeneku kochitidwa ndi asayansi akunja, komanso kuyesetsa kwa Prime Medicine ndi gulu lake lachitukuko mkati, kampaniyo ikuyembekeza kupititsa patsogolo kusinthasintha, kulondola, komanso kuchita bwino kwa Prime Editing. Mphamvu zomwe zafotokozedwa m'mapepala aposachedwa mu Nature Biotechnology ndi Cell zitha kupangitsa kuti pakhale njira zochiritsira zothandiza kwambiri pogwiritsa ntchito njira zosinthira majini.

Kupititsa patsogolo kumafanana ndi RNA (pegRNA) yokonzedwa bwino ya Prime Editing. Prime Editing imagwiritsa ntchito pegRNA molekyulu kuti ipeze cholowa cha jini ndikuwongolera kukonzanso kapena kusintha. M'nyuzipepala yomwe idasindikizidwa mu Nature Biotechnology pa Okutobala 4, 2021, olemba motsogozedwa ndi David R. Liu, m'modzi mwa omwe adayambitsa Prime Medicine, adawonetsa kuti ma pegRNAs (epegRNAs) opangidwa mwaluso amatha kupititsa patsogolo njira zosinthira kangapo. 

Kampaniyo ikutsatiranso njira zomwe zafotokozedwa posachedwa kuti zikwaniritse bwino ndikusintha njira inayake yokonzanso DNA. Mu pepala lofalitsidwa ku Cell pa Okutobala 14, 2021, olemba motsogozedwa ndi Liu ndi Britt Adamson adazindikira njira inayake yokonza DNA, yotchedwa mismatch kukonza njira, yomwe imathandizira kwambiri kukonza bwino. Adawonetsa kuti ntchito zosintha zitha kuchulukitsidwa kangapo, ndipo zosafunidwa ndizotsika zimatha kutsitsidwa kangapo, poyendetsa njira yolakwika yolakwika kudzera munjira zingapo.

Prime Medicine ili ndi ufulu wotsatsa kuchokera ku Broad Institute of MIT ndi Harvard kuti igwiritse ntchito Prime Editing pochizira anthu, pomwe asayansi ndi makampani padziko lonse lapansi akupitilizabe kugwiritsa ntchito Prime Editing pazofufuza ndi ntchito zina.

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Ponena za wolemba

Harry Johnson

Harry Johnson wakhala mkonzi wa ntchito ya eTurboNews pafupifupi zaka 20. Amakhala ku Honolulu, Hawaii, ndipo kwawo ndi ku Europe. Amasangalala kulemba ndikulemba nkhani.

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