Nkhani Zaku Australia Dinani apa ngati iyi ndi nkhani yanu yosindikiza! Health News

Zantrene Cancer Zatsopano Zamankhwala amateteza mtima ku imfa

Kampani yaku Australia ya biotech komanso yolondola ya oncology, Race Oncology, yalengeza kuyambika kwa kafukufuku wofufuza yemwe wapeza kuti Zantrene® imatha kuteteza maselo amtima kuti asafe ndikuwongolera kupha maselo a khansa ya m'mawere akagwiritsidwa ntchito limodzi ndi anthracycline, doxorubicin.

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  • Mankhwala a Race Oncology Zantrene awonetsedwa kuti amateteza maselo amtima wamunthu ku imfa ya anthracycline-induced chemotherapy. Anthracyclines ndi mankhwala omwe amagwiritsidwa ntchito kwambiri komanso othandiza kwambiri polimbana ndi khansa, komabe amatha kuwononga kwambiri mtima. 
  • Kafukufuku wam'mbuyomu adawonetsanso kuthekera kwa Zantrene kugwirizanitsa ndi anthracyclines omwe alipo kuti aphe bwino ma cell a khansa ya m'mawere. 
  • Chifukwa cha kufunikira kwa kupezedwaku, Zantrene idzathamangitsidwa kuchipatala ndi mayeso a Phase 2b omwe akukonzekera 2022 mwa odwala khansa ya m'mawere omwe ali pachiopsezo chachikulu cha kuwonongeka kwa mtima chifukwa cha anthracycline. 
  • Amapereka kuthekera kwazachipatala komanso zamalonda zobwerera kuchokera kumankhwala atsopano a Zantrene/anthracycline ndi kaphatikizidwe.

Aka ndi koyamba kuti mankhwalawa awonetsetse kuti amatha kutsata khansa komanso kuteteza mtima ku kuwonongeka kwa anthracycline. Kupeza kumeneku kumapereka chiyembekezo chatsopano kwa mamiliyoni ambiri odwala khansa padziko lonse lapansi omwe amalandila mankhwala a chemotherapy ndi anthracyclines ndipo ali pachiwopsezo cha kuwonongeka kwakukulu komanso kosatha kwa mitima yawo. 

Anthracyclines amadziwika kuti ndi mankhwala othandiza kwambiri oletsa khansa omwe adapangidwapo ndipo amagwiritsidwa ntchito pamitundu yambiri ya khansa kuposa gulu lina lililonse la anti-cancer[1], kuphatikizapo khansa ya m'magazi, lymphomas, neuroblastoma, impso, chiwindi, m'mimba, chiberekero, chithokomiro, ovarian, sarcoma, chikhodzodzo, khansa ya m'mapapo ndi m'mawere. Komabe, kuopa kuonongeka kwa anthracyclines pamtima kwapangitsa kuti akatswiri ambiri a oncology achepetse kugwiritsa ntchito mankhwalawa mogwira mtima kwambiri. Kupeza kwa Race kuli ndi kuthekera kosintha kagwiritsidwe ntchito ka anthracyclines polola akatswiri a oncology kugwiritsa ntchito mankhwalawa mwamphamvu kwambiri pothana ndi khansa popanda kuopa kuwonongeka kwa mtima kosatha.

The Zantrene® Pulogalamu yofufuza zachitetezo cha mtima ikutsogozedwa ndi akatswiri odziwika bwino a cardiotoxicity, Mapulofesa Othandizana nawo Aaron Sverdlov ndi Doan Ngo, mogwirizana ndi wasayansi ya khansa Wothandizira Pulofesa Nikki Verrills, ku Yunivesite ya Newcastle.

Wothandizira Pulofesa Aaron Sverdlov anati: "Mpaka pano, lingaliro lamankhwala omwe angakhalepo a khansa omwe si a cardiotoxic okha, koma, chitetezo cha cardio sichinayesedwe kapena kusangalatsidwa, makamaka chifukwa cha 'njira zokhudzana ndi matenda pazachipatala. Zotsatira zathu zikuwonetsa kuti Zantrene, mankhwala oletsa khansa, amatha kupereka chitetezo munthawi yomweyo ku zotsatira zoyipa zamtima kuchokera kwa amodzi mwa mankhwala omwe amagwiritsidwa ntchito kwambiri, doxorubicin. Uwu ndi umboni woyamba wamtundu wake wosonyeza kuti pali chithandizo chomwe chimalimbana ndi khansa ndikuteteza mtima! Izi zitha kupititsa patsogolo thanzi la odwala khansa komanso opulumuka ambiri mwa kuwongolera chithandizo chawo cha khansa ndikuletsa kukula kwa matenda amtima. ”

Ngakhale ichi ndichinthu chatsopano chosangalatsa, Zantrene® (bisantrene dihydrochloride) ili ndi mbiri yakale yachipatala, yomwe idapangidwa m'zaka za m'ma 1970 ngati njira yotetezeka yamtima kuposa anthracyclines [2] isanavomerezedwe ku France mu 1990s. Ngakhale chitetezo chamtima cha Zantrene chidatsimikiziridwa m'mayesero opitilira 50 azachipatala[3], , funso loti Zantrene angathandize kupewa kuwonongeka kwa mtima chifukwa cha anthracyclines sanayankhidwe.

Pothirira ndemanga pazotsatira zatsopanozi, mkulu wa sayansi ya Race, Dr Daniel Tillett adati: "Kupeza kuti Zantrene imatha kuteteza mtima ku chemotherapy komanso kupha khansa bwino ndi zotsatira zabwino kwambiri padziko lonse lapansi. Popeza kuti mankhwala a anthracycline amagwiritsidwa ntchito kwa odwala khansa mamiliyoni ambiri chaka chilichonse, n’kovuta kunena mopambanitsa kuti zimenezi n’zachipatala ndiponso n’zamalonda.”

Mawuwo

  • Muchitsanzo choyambirirachi, Zantrene imateteza maselo amtima kuti asawonongeke ndi doxorubicin pamene ikugwirizana ndi anthracyclines kuti aphe bwino maselo a khansa ya m'mawere. 
  • Race wapereka chiphaso cha patent chokhudzana ndi kuphatikiza kwa Zantrene ndi anthracycline pofuna kuteteza mtima wa odwala. Patent iyi (ngati itaperekedwa) ingateteze kuphatikizika kwa mankhwalawa ndikugwiritsa ntchito kwake kuchipatala mpaka 2041. 
  • Kupeza kwatsopano koteteza mtima kumeneku kudzapititsidwa patsogolo mwachangu ku chipatala. Mbiri yochuluka yazachipatala ya Zantrene imalola kuti kuphatikiza uku kupitirire patsogolo kuchipatala. 
  • Kukambitsirana kwapamwamba kukuchitika ndi azachipatala ku Australia kuti ayese kuyesa kwachipatala kwa Phase 2b kwa odwala khansa ya m'mawere omwe ali pachiopsezo chachikulu cha kuwonongeka kwa mtima kwa anthracycline. 
  • Kupeza kumeneku kumatsegula mwayi watsopano wamsika wa Zantrene wa zamankhwala ndi malonda ofanana ndi omwe adatulukira kale kuti Zantrene ndi choletsa champhamvu cha FTO.

Zotsatira Zotsatira

  • Maphunziro a zinyama aziyendetsedwa mu Q4 CY2021 / Q1CY2022. 
  • Maphunziro owonjezera achipatala kuti afufuze ngati Zantrene ingateteze mtima ku kuwonongeka ndi mankhwala ena a chemotherapeutic omwe amadziwikanso kuti amayambitsa kuwonongeka kwa mtima. 
  • Maphunziro owonjezera kuti adziwe momwe ma cell a Zantrene amathandizira pamtima. Izi zitha kulola kuzindikira ntchito zina zoteteza za Zantrene. 
  • Kupanga mankhwala atsopano komanso okhathamiritsa omwe ali ndi phindu lazachipatala komanso malonda. 
  • Kuyambitsidwa kwa mayeso a khansa ya m'mawere ya Phase 2b mu 2022.
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Ponena za wolemba

Wachinyamata T Steinmetz

Juergen Thomas Steinmetz wakhala akugwirabe ntchito zapaulendo komanso zokopa alendo kuyambira ali wachinyamata ku Germany (1977).
Iye adayambitsa eTurboNews mu 1999 ngati nkhani yoyamba yapaintaneti yantchito zapaulendo padziko lonse lapansi.

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