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Genital Psoriasis: Zotsatira za Phunziro Latsopano

Amgen lero adalengeza zotsatira zabwino zapamwamba kuchokera ku mayesero a DISCREET, Phase 3, multicenter, randomized, placebo-controlled, kafukufuku wapawiri kuti awone mphamvu ya Otezla® (apremilast) mwa akuluakulu omwe ali ndi psoriasis yapakati kapena yoopsa komanso yochepetsetsa. kwambiri zolengeza psoriasis.

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Kafukufukuyu adawonetsa kuti oral Otezla 30 mg kawiri tsiku lililonse idapindula bwino kwambiri poyerekeza ndi placebo, kumapeto kwenikweni kwa mayankho osinthidwa a static Physician's Global Assessment of Genitalia (sPGA-G) (otanthauzidwa ngati mphambu ya sPGA-G). zomveka bwino (0) kapena zomveka bwino (1) ndikuchepetsanso mfundo za 2 kuchokera pazoyambira) pa sabata 16.      

Kuonjezera apo, mapeto onse achiwiri adakumananso ndi kusintha kwatanthauzo komanso kwakukulu mu Genital Psoriasis Itch Numerical Rating Scale (GPI-NRS) yankho (lotanthauzidwa ngati kuchepetsedwa kwa mfundo za 4 kuchokera pa chiyambi cha GPI-NRS chizindikiro cha zizindikiro za Genital Psoriasis Symptoms. kwa maphunziro omwe ali ndi ziwerengero zoyambira ≥ 4); chigawo chokhudzidwa cha thupi (BSA) kusintha kuchokera pa chiyambi; Dermatology Life Quality Index (DLQI) kusintha kuchokera pazoyambira; ndi static Physician's Global Assessment (sPGA) yankho (lotanthauzidwa ngati sPGA mphambu yomveka bwino (0) kapena pafupifupi momveka bwino (1) ndi kuchepetsa 2-points kuchokera pachiyambi) pa sabata 16 ndi Otezla motsutsana ndi placebo.

Mtundu ndi kuchuluka kwa zochitika zoyipa zomwe zidawonedwa mu mayesowa zinali zogwirizana ndi mbiri yodziwika ya chitetezo cha Otezla. Zomwe zimanenedwa zovuta zomwe zidachitika mwa 5% mwa odwala omwe ali m'gulu lililonse lamankhwala anali kutsekula m'mimba, mutu, nseru ndi nasopharyngitis.

Odwala omwe amamaliza kuyesedwa kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kopanda khungu kopanda khungu kutseke (kuyesedwa kopanda khungu) kapena kusinthidwa ku Otezla gawo la gawo lowonjezera la phunziroli.

Zotsatira zatsatanetsatane za gawo la kafukufuku wa masabata a 16 omwe ali ndi khungu lachiwiri adzaperekedwa kuti akawonetsedwe pamsonkhano wachipatala womwe ukubwera.

Ku US, Otezla amavomerezedwa kuti azichiza odwala achikulire omwe ali ndi zilonda zam'kamwa zomwe zimagwirizanitsidwa ndi matenda a Behçet, odwala akuluakulu omwe ali ndi nyamakazi ya psoriatic komanso akuluakulu omwe ali ndi zilonda zamkamwa zomwe zimagwirizanitsidwa ndi Behçet's Disease. Kuyambira pomwe adavomerezedwa ndi FDA mu 2014, Otezla adalembedwa kwa odwala opitilira 650,000 padziko lonse lapansi omwe ali ndi matenda amtundu wamtundu wa psoriasis, nyamakazi ya psoriatic kapena Behçet's Disease.

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Ponena za wolemba

Linda Hohnholz, mkonzi wa eTN

Linda Hohnholz wakhala akulemba ndi kusintha zolemba kuyambira pomwe anayamba ntchito. Iye wagwiritsa ntchito chilakolako chobadwachi m'malo ngati Hawaii Pacific University, Chaminade University, Hawaii Children's Discovery Center, ndipo tsopano TravelNewsGroup.

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