Health News Nkhani

Nkhani Zachangu za Omicron: Johnson & Johnson atha kupanga Pfizer ndi Moderna Kukhala Bwino Kwambiri

Chiwerengero cha mayiko omwe akhudzidwa ndi kusinthika kwatsopano kwa Omicron
Chiwerengero cha mayiko omwe akhudzidwa ndi kusinthika kwatsopano kwa Omicron

The Johnson & Johnson COVID-19 Booster, Yoyendetsedwa Miyezi Sikisi Pambuyo pa Mlingo Wambiri wa BNT162b2, Ikuwonetsa Kuwonjezeka Kwakukulu kwa Mayankho a Antibody ndi T-cell.

Sangalalani, PDF ndi Imelo

 Johnson & Johnson (NYSE: JNJ) (Kampani) lero alengeza zotsatira zoyambira kuchokera ku kafukufuku wodziyimira pawokha, kuphatikiza gulu laling'ono la omwe adatenga nawo gawo pa kafukufuku wa COV2008 wothandizidwa ndi Janssen, wochitidwa ndi Dan Barouch, MD, Ph.D., et al. a Beth Israel Deaconess Medical Center (BIDMC), omwe adawonetsa kuti katemera wowonjezera wa katemera wa Johnson & Johnson COVID-19 (Ad26.COV2.S), woperekedwa patangotha ​​​​miyezi isanu ndi umodzi pambuyo pa mlingo woyamba wa BNT162b2, adawonjezera ma antibody. ndi mayankho a T-cell. Zotsatirazi zikuwonetsa phindu lomwe lingakhalepo pakukulitsa kwamtundu wa heterologous (kusakaniza-ndi-machesi). Nkhani yofotokoza zotsatira izi idayikidwapo mdRxiv.

"Pali umboni woyambirira wosonyeza kuti njira yophatikizira yophatikizika ndi machesi imatha kupatsa anthu mayankho osiyanasiyana a chitetezo chamthupi ku COVID-19 kuposa njira yolimbikitsira," atero a Dan Barouch, MD, Ph.D., Director wa Center for Kafukufuku wa Virology ndi Vaccine ku BIDMC. "M'kafukufuku woyambirira uyu, pamene mlingo wowonjezera wa Ad26.COV2.S unaperekedwa kwa anthu patatha miyezi isanu ndi umodzi pambuyo pa ndondomeko yoyamba ndi katemera wa BNT162b2, panali chiwonjezeko chofananira cha mayankho a antibody pa sabata lachinayi pambuyo pa kulimbikitsidwa ndi kuwonjezeka kwakukulu kwa katemera wa BNT8b26. Mayankho a CD2+ T-cell okhala ndi Ad162.COV2.S poyerekeza ndi BNTXNUMXbXNUMX.

"Zotsatirazi zimapereka chidziwitso chofunikira cha sayansi cha katemera wathu akagwiritsidwa ntchito ngati chilimbikitso chosakanikirana ndi machesi ndipo zitha kuthandiza kudziwitsa njira zolimbikitsira ndi cholinga chothana ndi mliriwu," atero a Mathai Mammen, MD, Ph.D., Global Head, Janssen. Research & Development, Johnson & Johnson. "Zidziwitso izi zikuwonjezera umboni womwe ukukulirakulira wosonyeza kuti kusakaniza ndi kuphatikizira kwa katemera wa Johnson & Johnson COVID-19 kumakulitsa bwino mayankho anthabwala ndi mayankho amafoni motsutsana ndi mtundu woyambirira wa SARS-CoV-2, komanso mitundu ya Beta ndi Delta."

Hese Phase 2 data imalimbikitsidwa ndi zotsatira zoyambirira zochokera ku UK COV-BOOST chipatala kafukufuku wofalitsidwa mu Lancet, zomwe zinasonyeza kuti kutsatira katemera woyamba ndi Mlingo iwiri ya BNT162b2 (n=106) kapena ChAdOx1 nCov-19 (n=108), mlingo wolimbikitsa wa katemera wa Johnson & Johnson COVID-19 unachulukitsa mayankho a antibody ndi T-cell.

Mayankho amafoni (T-Cell).

m kafukufuku woyambirira uyu, kulimbikitsa ndi katemera wa Johnson & Johnson COVID-19 pambuyo pa katemera woyamba wa BNT162b2 kukuwoneka kuti kumabweretsa kuwonjezeka kwakukulu kwa mayankho a CD8+ T-cell kuposa kulimbikitsa ndi BNT162b2. Zomwe zimayankhidwa ndi T-cell izi zikuwonetsa kusiyana pakati pa mayankho a chitetezo chamthupi kutsatira kukwera kofanana ndi BNT162b2, komanso kulimbikitsana kosakanikirana ndi katemera wa Johnson & Johnson COVID-19 kutsatira dongosolo loyambirira la BNT162b2.

Katemera wa Johnson & Johnson COVID-19 amathandizira AdVac ya Janssen® ukadaulo ndi chitetezo cham'ma cell, kuphatikiza mayankho a CD4+ ndi CD8+. Ma T-cell amatha kulunjika ndikuwononga ma cell omwe ali ndi kachilombo komwe kamayambitsa COVID-19. Mwachindunji, CD8+ T-maselo amatha kuwononga mwachindunji maselo omwe ali ndi kachilomboka ndipo amathandizidwa ndi CD4+ T-cell.

Mayankho a Humoral (Antibody). 

Katemera wa Johnson & Johnson COVID-19 ndi BNT162b2 monga zolimbikitsira zidapangitsa kuti ma anti-antibody asinthe chimodzimodzi ndi kumangiriza mitundu yoyambirira ya SARS-CoV-2, komanso mitundu ya Delta ndi Beta, milungu inayi itatha kulimbikitsidwa. Komabe, pambuyo pa kusakaniza ndi kufananitsa kwa katemera wa Johnson & Johnson COVID-19, ma antibodies adapitilira kuwonjezeka kwa milungu inayi pomwe mwa anthu omwe adalandira katemera wa BNT162b2, ma antibodies adatsika kuyambira sabata yachiwiri mpaka sabata. XNUMX post-boost.

Ma antibodies osalowerera ndale amatha kumangirira ku kachilomboka m'njira yoletsa matenda ndikutsekereza kachilomboka kupita kumtunda wakupuma. Ma antibodies omwe amamanga amatha kumangirira ku protein ya spike ya virus ndikuyambitsa kachilomboka kudzera m'matenda osaletsa ma virus.

Kupanga Phunziro

Pa kafukufukuyu, chitsanzo cha biorepository ku Beth Israel Deaconess Medical Center (BIDMC) chinapeza zitsanzo kuchokera kwa anthu omwe adalandira katemera wa BNT162b2. Otenga nawo mbali adapitilizabe kutsatira mu biorepository ndipo adalimbikitsidwa ndi 30 ug BNT162b2 (n=24) kapena adalembetsa mu kafukufuku wa COV2008 (NCT04999111) ndipo adalimbikitsidwa ndi 5, 2.5, kapena 1 × 1010 vp wa katemera wa Johnson & Johnson COVID-19 (n=41). Kafukufuku wa COV2008 ndi Johnson & Johnson wothandizidwa, wopitilira, woyeserera wakhungu wa Phase 2 (VAC31518COV2008) kuti awunike katemera wake wa COVID-19 ngati chilimbikitso mwa akulu azaka 18 ndi kupitilira apo.

Bungwe la US Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunisation Practices (ACIP) lalimbikitsa katemera wa Johnson & Johnson COVID-19 ngati chilimbikitso kwa anthu onse oyenerera azaka 18 kapena kupitilira apo omwe amalandira katemera wovomerezeka wa COVID-19.

Johnson & Johnson akupitiriza kupereka zofunikira kwa olamulira ena, World Health Organization (WHO) ndi National Immunisation Technical Advisory Groups (NITAGs) padziko lonse lapansi kuti adziwitse kupanga zisankho za njira zoyendetsera katemera, ngati pakufunika.

Mogwirizana ndi magulu ophunzira ku South Africa komanso padziko lonse lapansi, Kampani yakhala ikuwunika momwe katemera wake wa COVID-19 akugwirira ntchito m'mitundu yosiyanasiyana, kuphatikiza watsopano komanso yemwe akufalikira mwachangu. Omicron osiyanasiyana. Kuphatikiza apo, Kampani ikutsata katemera wa Omicron wosiyanasiyana ndipo ipititsa patsogolo pakafunika.

Kuti mumve zambiri za njira zamakampani zothandizira kuthana ndi mliriwu, pitani: www.jnj.com/covid-19.

Ntchito Yovomerezeka

Katemera wa Johnson & Johnson COVID-19, yemwe amadziwikanso kuti Janssen COVID-19 Vaccine, ndiololedwa kugwiritsidwa ntchito pansi pa Emergency Use Authorization (EUA) pakutemera kogwira popewa matenda a Coronavirus 2019 (COVID-19) omwe amayamba chifukwa cha kupuma kwambiri. matenda a coronavirus 2 (SARS-CoV-2).

  • Katemera woyamba wa Katemera wa Janssen COVID-19 ndi mlingo umodzi (0.5 mL) woperekedwa kwa anthu azaka 18 ndi kupitilira apo. 
  • Mlingo umodzi wa Janssen COVID-19 Vaccine booster (0.5 mL) utha kuperekedwa patadutsa miyezi iwiri kuchokera pamene katemera woyamba adalandira kwa anthu azaka 2 kapena kuposerapo. 
  • Mlingo umodzi wowonjezera wa Katemera wa Janssen COVID-19 (0.5 mL) utha kuperekedwa kwa anthu azaka 18 kapena kuposerapo ngati mulingo wowonjezera wa heterologous akamaliza katemera woyamba ndi katemera wina wovomerezeka kapena wovomerezeka wa COVID-19. The dosing imeneyi kwa heterologous chilimbikitso mlingo ndi chimodzimodzi kuti analoleza chilimbikitso mlingo wa katemera ntchito yoyamba katemera.

ZOFUNIKA ZOFUNIKA ZA CHITETEZO

funsani wopereka katemera za matenda anu onse, kuphatikiza ngati:

  • ali ndi chifuwa chilichonse 
  • ndikutentha thupi 
  • ali ndi vuto lakukha magazi kapena ali ndi magazi ochepa 
  • ali ndi chitetezo chokwanira kapena ali pamankhwala omwe amakhudza chitetezo chanu cha mthupi 
  • ali ndi pakati kapena akufuna kukhala ndi pakati 
  • akuyamwitsa 
  • alandila katemera wina wa COVID-19 
  • adakomokapo molumikizana ndi jakisoni

Simuyenera kulandira Katemera wa Janssen COVID-19 ngati:

  • anali ndi vuto losagwirizana kwambiri ndi mankhwalawa atalandira kale katemerayu 
  • anali ndi ziwengo kwambiri pa chilichonse cha katemerayu.

Katemera wa Janssen COVID-19 adzapatsidwa kwa inu ngati jakisoni wa minofu.

Katemera Woyamba: Katemera wa Janssen COVID-19 amaperekedwa ngati mlingo umodzi.

Mlingo Wowonjezera:

  • Mlingo umodzi wowonjezera wa Katemera wa Janssen COVID-19 utha kuperekedwa patadutsa miyezi iwiri mutalandira katemera woyamba wa Janssen COVID-19 Vaccine. 
  • Mlingo umodzi wowonjezera wa Katemera wa Janssen COVID-19 utha kuperekedwa kwa anthu azaka 18 kapena kuposerapo omwe amaliza katemera woyamba ndi katemera wina wovomerezeka kapena wovomerezeka wa COVID-19. Chonde funsani ndi wothandizira zaumoyo wanu za nthawi ya mlingo wa booster.

Zotsatira zoyipa zomwe zafotokozedwa ndi Katemera wa Janssen COVID-19 ndi awa:

  • Jekeseni malo zochita: ululu, redness wa khungu, ndi kutupa. 
  • Zotsatira zoyipa: mutu, kutopa kwambiri, kupweteka kwa minofu, nseru, kutentha thupi. 
  • Kutupa kwa ma lymph nodes. 
  • Kuundana kwamagazi. 
  • Kumverera kosazolowereka pakhungu (monga kugwedeza kapena kukwawa) (paresthesia), kuchepa kwakumverera kapena kukhudzidwa, makamaka pakhungu (hypoesthesia). 
  • Kulira kosalekeza m'makutu (tinnitus). 
  • Kutsekula m'mimba, kusanza.

Pali mwayi woti katemera wa Janssen COVID-19 atha kuyambitsa mavuto ena. Matendawa amatha kupezeka patangopita mphindi zochepa mpaka ola limodzi mutalandira katemera wa Janssen COVID-19. Pachifukwa ichi, omwe amakupatsani katemera angakufunseni kuti mukhale pamalo omwe munalandira katemera wanu kuti muwone pambuyo pa katemera. Zizindikiro zakusavomerezeka kwambiri zimatha kuphatikiza:

  • Kuvuta kupuma 
  • Kutupa kwa nkhope ndi mmero 
  • Kugunda kwamtima mwachangu 
  • Chiphuphu choipa pa thupi lanu lonse 
  • Chizungulire ndi kufooka

Magazi Omangika Ndi Mipata Yotsika Yamaplateleti

Kuundana kwamagazi komwe kumakhudza mitsempha yamagazi muubongo, mapapo, pamimba, ndi miyendo limodzi ndi ma platelet otsika (maselo amwazi omwe amathandiza thupi lanu kuti lisatuluke magazi), zachitika mwa anthu ena omwe alandila Katemera wa Janssen COVID-19. Mwa anthu omwe adapanga magazi otundumuka ndi ma platelet otsika, zizindikilo zimayamba pafupifupi sabata limodzi kapena awiri mutalandira katemera. Kunena zakumagazi kwa magazi ndi kuchuluka kwamagazi m'maplateleti kwakhala kwakukulu kwambiri mwa akazi azaka zapakati pa 18 mpaka 49. Mpata woti izi zichitike ndikutali. Muyenera kupita kuchipatala nthawi yomweyo ngati muli ndi zizindikiro zotsatirazi mutalandira Katemera wa Janssen COVID-19:

  • Kupuma pang'ono, 
  • Kupweteka pachifuwa, 
  • Kutupa kwa mwendo, 
  • Kupweteka kwam'mimba kosalekeza, 
  • Kupweteka kwamutu kwakukulu kapena kosalekeza kapena kusawona bwino, 
  • Kuvulala kosavuta kapena ting'onoting'ono tating'ono ta magazi pansi pa khungu kupitirira pamene jekeseni.

Izi sizotheka kukhala zotsatira zoyipa za Katemera wa Janssen COVID-19. Zovuta zazikulu komanso zosayembekezereka zitha kuchitika. Katemera wa Janssen COVID-19 akadaphunziridwabe m'mayesero azachipatala.

Guillain Barré Syndrome

Matenda a Guillain Barré (matenda amanjenje momwe chitetezo chamthupi chimawonongera mitsempha, ndikupangitsa kufooka kwa minofu komanso nthawi zina kufooka) kwachitika mwa anthu ena omwe alandila Katemera wa Janssen COVID-19. Mwa ambiri mwa anthuwa, zizindikiro zidayamba mkati mwa masiku 42 atalandira Katemera wa Janssen COVID-19. Mwayi woti izi zichitike ndiwotsika kwambiri. Muyenera kupita kuchipatala nthawi yomweyo ngati mungapeze zizindikiro izi mutalandira Katemera wa Janssen COVID-19:

  • Kufooka kapena kumva kulasalasa, makamaka m'miyendo kapena m'manja, zomwe zikuipiraipira ndikufalikira ku ziwalo zina zathupi. 
  • Kuvuta kuyenda. 
  • Kuvuta ndi mayendedwe a nkhope, kuphatikiza kuyankhula, kutafuna, kapena kumeza. 
  • Kuwona kawiri kapena kulephera kusuntha maso. 
  • Kuvuta kulamulira chikhodzodzo kapena matumbo.

Sangalalani, PDF ndi Imelo

Ponena za wolemba

Wachinyamata T Steinmetz

Juergen Thomas Steinmetz wakhala akugwirabe ntchito zapaulendo komanso zokopa alendo kuyambira ali wachinyamata ku Germany (1977).
Iye adayambitsa eTurboNews mu 1999 ngati nkhani yoyamba yapaintaneti yantchito zapaulendo padziko lonse lapansi.

Siyani Comment

1 Comment

  • Chogulitsachi chili ndi machenjezo ambiri komanso zoyipa. Ndi zotetezeka ngati Alex Baldwin mu seti ya kanema. Ndikulakalaka akadayimitsa katemerayu ndikupeza kachilombo koyenera, kotetezeka, kothandiza komwe kamachiza kachilomboka kapena kachilomboka kalikonse chifukwa andipangira zida zambiri zamoyo.