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Matenda a Huntington: Chithandizo Chatsopano Chotheka cha Chorea

Neurocrine Biosciences lero yalengeza zabwino zapamwamba kuchokera mu Gawo 3 KINECT-HD kafukufuku wowunika mphamvu, chitetezo ndi kulolera kwa valbenazine, chosankha cha vesicular monoamine transporter 2 (VMAT2) inhibitor yomwe ikufufuzidwa ngati chithandizo kamodzi patsiku kwa akuluakulu omwe amakhudzidwa ndi chorea. ndi matenda a Huntington (HD).

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Kafukufukuyu adakumana ndi mfundo yayikulu yochepetsera kuuma kwa chorea, mawonekedwe a cardinal motor mu matenda a Huntington, monga momwe amayezedwera ndi kusintha kwa Unified Huntington's Disease Rating Scale (UHDRS®) Total Maximal Chorea (TMC) kuyambira poyambira mpaka pa avareji. masabata 10 ndi 12.                

Mu phunziro la KINECT-HD losasinthika, lopanda khungu, lopangidwa ndi placebo, chithandizo cha valbenazine chinapangitsa kuti chiwerengero cha TMC chichepetse chiwerengero cha 3.2 units (p <0.0001), kusonyeza kusintha kwakukulu kwa chiwerengero cha chorea. Kupambana kwa TMC ndi gawo la kuwunika kwa injini ya UHDRS® ndikuyesa chorea m'zigawo zisanu ndi ziwiri za thupi, kuphatikiza nkhope, chigawo chamkamwa-buccal-lingual, thunthu ndi nthambi iliyonse payokha. Chiwerengero cha TMC ndi chiwerengero cha ziwerengero zapayekha ndipo zimachokera ku 0 mpaka 28. Mapeto achiwiri a Clinical Global Impression of Change (CGI-C) Response Status ndi Patient Global Impression of Change (PGI-C) Response Status analinso ofunika kwambiri. mokomera chithandizo cha valbenazine.

Zochizira zomwe zidachitika muzoyesererazi zinali zogwirizana ndi mbiri yodziwika bwino yachitetezo cha valbenazine. Palibe khalidwe lodzipha kapena kuwonjezereka kwa malingaliro ofuna kudzipha omwe adawonedwa m'mitu yothandizidwa ndi valbenazine mu phunziro ili. Zambiri kuchokera mu kafukufuku wa Phase 3 KINECT-HD zidzaperekedwa pamsonkhano wachipatala mu 2022.

HD imakhudza akuluakulu pafupifupi 30,000 ku United States. Chorea, vuto loyenda modziyimira pawokha lomwe limadziwika ndi kusuntha kosakhazikika komanso kosadziwikiratu, ndi chimodzi mwazizindikiro zodziwika bwino, zomwe zimakhudza pafupifupi 90% mwa omwe amapezeka ndi matenda a Huntington panthawi ya matenda.

KINECT-HD2 ndi kafukufuku wotseguka kuti awone zachitetezo chanthawi yayitali komanso kulekerera kwa valbenazine pochiza chorea ku matenda a Huntington.

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Ponena za wolemba

Linda Hohnholz, mkonzi wa eTN

Linda Hohnholz wakhala akulemba ndi kusintha zolemba kuyambira pomwe anayamba ntchito. Iye wagwiritsa ntchito chilakolako chobadwachi m'malo ngati Hawaii Pacific University, Chaminade University, Hawaii Children's Discovery Center, ndipo tsopano TravelNewsGroup.

Siyani Comment

1 Comment

  • Ndikudziwa, kuyang'anira odwala omwe ali ndi chorea, makamaka matenda a Huntington, ndi ntchito yovuta yomwe imafuna luso m'madera angapo. Zomwe zimagwiritsidwa ntchito kwambiri pochiza chorea ndi neuroleptics. Maziko a machitidwe awo amaganiziridwa kuti ndi okhudzana.