Kuyesa Kwatsopano Kwachipatala kwa Odwala Omwe Ali ndi Critical COVID-19 Pneumonia

Mlanduwu wapangidwa kuti upeze zambiri za chitetezo cha odwala ndi Auxora, kuyesa chitetezo ndi mphamvu ya Auxora pamodzi ndi tocilizumab ndi corticosteroids, ndikuwunika chitetezo ndi mphamvu za masiku atatu ndi asanu ndi limodzi a dosing. Kampaniyo posachedwapa idanenanso zamtundu wapamwamba kuchokera ku mayeso ake a CARDEA Phase 2 omwe amathandizira maphunziro owonjezera pa odwalawa. 

CARDEA-Plus ilembetsa odwala a chibayo a COVID-19 omwe ali ndi chiyerekezo cha PaO2/FiO2 (P/F) cha ≤200 omwe amafunikira kuchuluka kwa nasal cannula (HFNC) kapena mpweya wosavutikira (NIV). Odwala adzalandira mlingo woyambirira wa 2.0 mg/kg wa Auxora wotsatiridwa ndi 1.6 mg/kg pa maola 24, ndi 1.6 mg/kg pa maola 48. Odwala omwe ali ndi chiŵerengero cha P/F cha ≤100 kapena pa mpweya wabwino pa maola 48 adzakhala oyenerera kuti alandire Mlingo atatu wa Auxora kapena atatu a placebo. Odwala onse adzalandira chithandizo choyenera chomwe chitha kuphatikizapo kugwiritsa ntchito corticosteroids ndi/kapena tocilizumab.

"Ngakhale kuchuluka kwa katemera wa COVID-19 kukuchulukirachulukira, kuchuluka kwa anthu ogonekedwa m'chipatala ndi kufa kudakali vuto lalikulu," atero Sudarshan Hebbar, MD, Chief Medical Officer wa CalciMedica. "Ngakhale tocilizumab yakhala ikugwiritsidwa ntchito kwambiri kwa odwala omwe agonekedwa m'chipatala ndi COVID-19, pakufunikabe kukonza zotulukapo za odwala. Tikukhulupirira kuti Auxora ili ndi njira yapadera yochitira zinthu komanso mankhwala omwe angapereke chithandizo chamankhwala kwa odwala omwe ali ndi chibayo cha COVID-19. ”

"Kuyambitsa kafukufukuyu, komwe kumalolanso kuwongolera kwa Auxora yokhala ndi tocilizumab ndi corticosteroids mwa odwala omwe ali ndi chibayo chovuta kwambiri cha COVID-19, ndichinthu chofunikira kwambiri pakampani yathu," atero a Rachel Leheny, Ph.D., Chief Executive Officer wa CalciMedica. . "Chofunika kwambiri, zotsatira za kafukufukuyu, zotsatiridwa ndi zokambirana ndi a FDA, zidzadziwitsa mapangidwe a mayesero achipatala a Gawo 3 kumapeto kwa chaka chino. Talandira chidwi chachikulu ndi chithandizo kuchokera ku malo ochita kafukufuku pa kafukufukuyu ndipo tikuyembekeza kulembetsa mwamsanga. "