Zatsopano Zam'mene Crosstalk Pakati pa Pancreatic Maselo Angayendetsere Matenda a Shuga Osowa

Written by mkonzi

Ma enzymes omwe amagayidwa m'mimba amaphatikizana m'maselo a beta apafupi omwe amapanga insulini, zomwe zimayambitsa matenda obadwa nawo omwe amatha kuwunikira matenda ena a kapamba.

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Mu kapamba, ma cell a beta omwe amapanga insulin amaphatikizidwa ndi maselo ena a endocrine omwe amapanga mahomoni ndipo amazunguliridwa ndi ma cell a pancreatic exocrine omwe amatulutsa michere ya m'mimba. Ofufuza a Joslin Diabetes Center tsopano awonetsa momwe mtundu umodzi wa matenda osowa obadwa nawo omwe amadziwika kuti okhwima akuyamba shuga achichepere (MODY) amayendetsedwa ndi ma enzyme osinthika omwe amapangidwa m'maselo a pancreatic exocrine omwe kenako amatengedwa ndi ma cell a beta oyandikana nawo a insulin.

Kupeza uku kungathandize kumvetsetsa matenda ena a kapamba, kuphatikiza mtundu wa 1 kapena mtundu wa 2 shuga, momwe kuphatikizika kwa maselo pakati pamagulu awiriwa kumatha kuwononga, adatero wofufuza wamkulu wa Joslin Rohit N. Kulkarni, MD, PhD. Co-Section Head of Joslin's Islet and Regenerative Biology Section ndi Pulofesa wa Zamankhwala ku Harvard Medical School.

Mitundu yambiri ya MODY imayamba chifukwa cha kusintha kumodzi kwa jini komwe kumawonetsa mapuloteni m'maselo a beta. Koma mumtundu umodzi wa MODY wotchedwa MODY8, jini yosinthika m'maselo oyandikana nawo a exocrine amadziwika kuti ayambitsa izi, atero Kulkarni, wolemba nawo papepala la Nature Metabolism lomwe likupereka ntchitoyi. Asayansi mu labotale yake adapeza kuti mu MODY8, ma enzymes am'mimba opangidwa ndi jini yosinthika iyi m'maselo a beta ndikuwononga thanzi lawo komanso ntchito yotulutsa insulin.

"Ngakhale endocrine ndi exocrine kapamba amapanga magawo awiri osiyana okhala ndi ntchito zosiyanasiyana, ubale wawo wapamtima umapangitsa tsogolo lawo," atero Sevim Kahraman, PhD, wofufuza za postdoctoral mu labu ya Kulkarni komanso wolemba wamkulu wa pepalalo. "Matenda omwe amayamba m'gawo limodzi amasokoneza ena."

"Ngakhale kuti MODY8 ndi matenda osowa kwambiri, ikhoza kuwunikira njira zomwe zimayambitsa matenda a shuga," anatero Anders Molven, PhD, wolemba komanso Pulofesa pa yunivesite ya Bergen ku Norway. "Zomwe tapeza zikuwonetsa momwe matenda omwe amayamba mu kapamba wa exocrine amatha kukhudzira ma cell a beta omwe amapanga insulin. Tikuganiza kuti kuphatikizika koyipa koteroko kwa exocrine-endocrine kungakhale kofunikira kwambiri pakumvetsetsa matenda ena amtundu woyamba wa shuga. ”

Kulkarni adalongosola kuti jini yosinthika ya CEL (carboxyl ester lipase) ku MODY8 imawonedwanso ngati jini yowopsa ya matenda amtundu woyamba. Izi zimadzutsa funso ngati matenda ena amtundu wa 1 shuga amakhalanso ndi mapuloteni osakanikirana awa m'maselo a beta, adatero.

Kafukufukuyu adayamba ndikusintha mzere wa cell wa exocrine (acinar) kuti uwonetse puloteni ya CEL yosinthika. Ma cell a beta akasambitsidwa munjira kuchokera ku maselo osinthika kapena abwinobwino a exocrine, ma cell a beta adatenga mapuloteni osinthika komanso abwinobwino, ndikubweretsa kuchuluka kwa mapuloteni osinthika. Mapuloteni abwinobwino adawonongeka ndi machitidwe anthawi zonse m'maselo a beta ndipo adazimiririka kwa maola angapo, koma mapuloteni osinthika sanatero, m'malo mwake adapanga zophatikiza zama protein.

Nanga zophatikizazi zidakhudza bwanji magwiridwe antchito ndi thanzi la ma cell a beta? Pakuyesa kotsatizana, Kahraman ndi anzawo adatsimikizira kuti ma cell sanatulutse insulini komanso pakufunika, amachulukira pang'onopang'ono ndipo amakhala pachiwopsezo cha kufa.

Anatsimikizira zomwe apezazi kuchokera ku ma cell ndi kuyesa m'maselo kuchokera kwa anthu omwe amapereka. Kenako, adayikanso ma cell a exocrine amunthu (akuwonetsanso ma enzyme osinthika kapena wamba) pamodzi ndi ma cell a beta amunthu kukhala mbewa yopangidwa kuti ivomereze ma cell amunthu. "Ngakhale muzochitika izi, amatha kuwonetsa kuti mapuloteni osinthika amatengedwanso kwambiri ndi selo la beta poyerekeza ndi mapuloteni abwinobwino, ndipo amapanga magulu osasungunuka," adatero Kulkarni.

Kuphatikiza apo, poyang'ana kapamba kuchokera kwa anthu omwe ali ndi MODY8 omwe adamwalira ndi zifukwa zina, ofufuzawo adawona kuti ma cell a beta anali ndi mapuloteni osinthika. "Kwa opereka athanzi, sitinapeze mapuloteni abwinobwino mu cell ya beta," adatero.

"Nkhani iyi ya MODY8 idayamba ndikuwunikira odwala omwe ali ndi matenda ashuga omwe ali ndi vuto la m'mimba, zomwe zidapangitsa kuti pakhale chibadwa chofanana," adatero Helge Raeder, MD, wolemba nawo komanso Pulofesa ku Yunivesite ya Bergen. "Mukafukufuku wapano, timatseka bwaloli polumikiza zomwe zapezeka m'chipatala izi. Mosiyana ndi zomwe tinkayembekezera, enzyme yomwe imapangidwira m'matumbo m'malo mwake idasokeretsedwa kuti ilowe m'matumbo a kapamba omwe ali ndi matenda, kenako ndikusokoneza katulutsidwe ka insulin.

Masiku ano, anthu omwe ali ndi MODY8 amathandizidwa ndi insulin kapena mankhwala a shuga amkamwa. Kulkarni ndi anzake ayang'ana njira zopangira chithandizo chamakono komanso chamunthu payekha. "Mwachitsanzo, kodi titha kusungunula zophatikiza za mapuloteniwa, kapena kuchepetsa kuphatikizika kwawo mu cell ya beta?" adatero. "Titha kutsatira zomwe taphunzira m'matenda ena monga matenda a Alzheimer's ndi Parkinson's omwe ali ndi njira yophatikizira m'maselo."

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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