Kuyesa Kwatsopano Kwachipatala kwa Chithandizo cha Khansa ya Prostate

Written by mkonzi

Hinova Pharmaceuticals Inc., kampani yachipatala ya biopharmaceutical yomwe imayang'ana kwambiri pakupanga zithandizo zaposachedwa za khansa ndi matenda a metabolic kudzera muukadaulo wowonongera mapuloteni, adalengeza kuti wodwala woyamba yemwe ali ndi metastatic castration-resistant prostate cancer (mCRPC) adamuyeza bwino mu Gawo I. mayesero azachipatala a HP518, chosokoneza chosankha kwambiri komanso chopezeka pakamwa choloza androgen receptor (AR). Phunziro lotseguka la Phase I lomwe likupitilirabe ku Australia liwunika zachitetezo, pharmacokinetics, ndi anti-tumor zochita za HP518 mwa odwala omwe ali ndi mCRPC.

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HP518 yapezedwa ndikupangidwa ndi nsanja ya Hinova yomwe imayang'anira kuwononga mapuloteni. Ili ndi kuthekera kothana ndi kukana kwamankhwala kwa khansa ya prostate chifukwa cha kusintha kwina kwa AR.

Chimeric degraders ndi mamolekyu ang'onoang'ono omwe amagwira ntchito kawiri omwe amalimbikitsa kuwonongeka kwa mapuloteni omwe amawunikira omwe ali ndi mphamvu zambiri komanso kusankha kwakukulu. Ukadaulowu uli ndi kuthekera kolunjika kwa omwe sangamwe mankhwala osokoneza bongo komanso kuthana ndi vuto lakusamva mankhwala lamankhwala ang'onoang'ono amtundu wa molekyulu.

"Ichi ndi chofunikira kwambiri pakupita patsogolo kwa zoyesayesa zathu kuyambira pakupeza mankhwala osokoneza bongo mpaka kafukufuku wachipatala," adatero Yuanwei Chen, Ph.D., Purezidenti ndi CEO wa Hinova. "Ndife okondwa nazo ndipo tadzipereka kubweretsa njira zatsopano zothandizira odwala padziko lonse lapansi!"

Kupyolera mu njira yopezera mankhwala owononga mapuloteni, Hinova amatha kuyang'ana ntchito yowonongeka kwa mapuloteni mofulumira ndikukonzekera bwino komanso kukhathamiritsa kwa zowononga chimeric. Kuphatikiza apo, Hinova ali ndi chidziwitso chambiri pakuwongolera mankhwala opangira mankhwala a Chimeric degrader compounds.

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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