Antibody Watsopano Amasokoneza Omicron ndi Zosiyanasiyana

Written by mkonzi

Sorrento Therapeutics, Inc. lero yalengeza kutulutsidwa kwa zidziwitso zatsopano za Omicron variant neutralizing antibody (nAb) STI-9167, COVISHIELD, antibody yapamwamba yomwe idapezeka ndikupangidwa kuti iyesedwe mumgwirizano womwe ukupitilira pakati pa akatswiri ammunologists ndi ma virus ku Sorrento ndi Icahn. School of Medicine ku Mount Sinai ku New York, NY.

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Zoyesa zomangira mapuloteni a Spike ndi kuyeserera kosagwirizana ndi ma virus omwe akuyimira mitundu yonse yodziwika ya SARS-CoV-2 (VOCs) yamalizidwa ndi STI-9167, ndipo nAb iyi idawonedwa kuti imamanga ndi kuyanjana kwambiri ndikupereka ntchito yamphamvu kwambiri yochepetsera mphamvu (Omicron IC50). = 25 ng/ml). Chofunikira chodziwika bwino, STI-9167 ndi yapadera poyerekeza ndi mayeso a SARS-CoV-2 nAbs ovomerezedwa ndi EUA momwe zinthu zomangira ndi kusalowerera ndale zimasungidwa motsutsana ndi mitundu yomwe ikubwera ya Omicron ndi Omicron (+R346K), mtundu womwe ukuchulukirachulukira wa mzere wa Omicron womwe imayikanso kusintha kwa mapuloteni a R346K Spike. Kuphatikiza apo, STI-9167 yoperekedwa pamlingo wochepera (5mg/kg) ndi njira zam'mphuno kapena zamtsempha imapereka chitetezo champhamvu kuzizindikiro zakudwala ndi mtundu wa Omicron mumtundu wa K18-hAce2 transgenic mbewa wa COVID-19, kuteteza kulemera. kutaya ndi kuchepetsa titers ma virus m'mapapo mpaka osawoneka.

"Mbadwo ndi mawonekedwe a STI-9167 nAb akuwonetsa mgwirizano waukulu pakati pa asayansi a Mount Sinai ndi Sorrento kuthana ndi vuto laumoyo padziko lonse lapansi," atero a Domenico Tortorella, PhD, Pulofesa wa Microbiology ku Icahn Mount Sinai.

"Tidasankha antibody STI-9167 kuchokera m'magulu akuluakulu a anti-SARS-CoV-2 amtundu wa anti-spike neutralizing omwe tidapanga m'ma laboratories athu. Idawonetsa kusalowerera ndale kothandiza kwambiri motsutsana ndi zodzipatula zonse zodziwika za SARS-CoV-2 ndi nkhawa zosiyanasiyana, kuphatikiza mitundu yaposachedwa ya Omicron ndi Omicron (+R346K)," adatero J. Andrew Duty, PhD, Pulofesa Wothandizira wa Microbiology ndi Director of Center for Therapeutic Antibody Development ku Icahn Mount Sinai.

"Ma nAbs omwe pano akuvomerezedwa ndi EUA achepetsa kwambiri kapena kulibe ntchito zomangirira komanso zosagwirizana ndi omicron/omicron (+R346K) zomwe zimawapangitsa kukhala osakwanira kukwaniritsa zosowa zachipatala," adatero Mike A. Royal, MD, JD, MBA, Chief Medical Officer ku. Sorrento. "Alternative nAbs ndizofunikira kwambiri posachedwa, makamaka kwa ana omwe akuwoneka kuti ali pachiwopsezo chachikulu chotenga matenda a omicron komanso kugona m'chipatala. Mapangidwe athu amkati a COVIDROPS amatumiza ma nAbs athu kunjira zakumtunda komwe Omicron amatha kulunjika ndikutukuka, ndipo monga chithandizo chosasokoneza, chosavuta kupereka, ndi choyenera kwa ana. Tayamba kale kuchiza ana omwe ali ndi COVIDROPS (omwe ali ndi STI-2099) ku Mexico komwe kusiyanasiyana kwa delta kukadali kofala. Kupyolera mu maphunziro a Gawo 2 ku US, United Kingdom ndi Mexico, tawona mbiri yabwino yoteteza ma nAbs athu m'mphuno ndipo tikuyembekeza zotsatira zofanana ndi COVIDROP (ndi STI-9167).

"Tsopano takhala ndi chidziwitso pakubweretsa zithandizo zingapo za COVID-19 m'chipatala ndikupita patsogolo angapo mu Gawo 2 komanso / kapena chitukuko chofunikira," akutero a Mark Brunswick, PhD, SVP komanso Head of Regulatory Affairs and Quality ku Sorrento. "Tili bwino kuti titulutse COVISHIELD mwachangu kudzera mu gawo la IND komanso kuchipatala ndipo tikuyembekeza kutumiza IND yofunikayi mwezi wamawa."

Dr. Henry Ji, Wapampando ndi Mtsogoleri wamkulu wa Sorrento, anati, "Ntchito za magulu a Sorrento ndi Mount Sinai zapereka antibody yodabwitsa komanso yamtengo wapatali yotetezera Omicron ndi ma SARS-CoV-2 VOC ena onse. Antibody yathu ya COVISHIELD yoletsa kusokoneza chitetezo ndiyomwe ili mkalasi yabwino kwambiri komanso ndiyopambana kwambiri polimbana ndi ma Omicron omwe akupezeka ndi ma Omicron (+R346K) VOC. Tikugwira ntchito mwakhama kuti tiyike anti antiyi kuti igwiritsidwe ntchito kwa odwala a COVID ndipo tili ndi chidaliro kuti njira yathu ipereka yankho lothandiza osati posachedwa komanso pomwe mliri ukupitilirabe. ”

Zolemba zolembedwa pamanja zidatumizidwa pa Januware 19, 2022 ndipo zidzasindikizidwa posachedwa pa intaneti biorxiv.org.

Ma anti anti anti omwe akufotokozedwa adapangidwa m'malo opangira ma laboratories pa Phiri la Sinai ndipo ali ndi chilolezo cha Sorrento Therapeutics. Mamembala a Mount Sinai ndi a Mount Sinai ali ndi chidwi pazachuma ku Sorrento Therapeutics.

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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