Njira Yatsopano Yolowera Kuzindikira Kwachangu kwa COVID-19 Yopakidwa Golide

Written by mkonzi

Ofufuzawo adagwiritsa ntchito ma nanoparticles agolide kupanga njira yatsopano yodziwira ma cell yomwe imachepetsa kwambiri nthawi yofunikira kuti azindikire COVID-19.

Sangalalani, PDF ndi Imelo

Kufalikira kwachangu kwa COVID-19, matenda oyambitsidwa ndi kachilombo ka SARS-CoV-2, kwadzetsa vuto la thanzi la anthu padziko lonse lapansi. Kuzindikira koyambirira kwa COVID-19 ndikudzipatula ndikofunikira pakuwongolera kufala kwa matenda ndikuteteza anthu omwe ali pachiwopsezo. Muyezo wapano wa matenda a COVID-19 ndi reverse transcriptase-polymerase chain reaction (RT-PCR), njira yomwe majini a ma virus amazindikirika atadutsa kambirimbiri. Komabe, njira imeneyi imatenga nthawi, ikupanga kulephera kuyesa m'malo onse ozindikira matenda ndikupangitsa kuti matenda achedwe.      

Pakafukufuku waposachedwa wofalitsidwa mu Biosensors ndi Bioelectronics, ofufuza ochokera ku Korea ndi China abweretsa nsanja yatsopano ya nanotechnology yomwe ingafupikitse nthawi yofunikira kuti adziwe kuti ali ndi COVID-19. Mawonekedwe awo apamwamba a Raman scattering (SERS) -PCR - okonzedwa pogwiritsa ntchito ma nanoparticles a golide (AuNPs) m'mabowo a Au 'nanodimple' substrates (AuNDSs) - amatha kuzindikira majini a mavairasi pambuyo pa mizungu 8 yokha ya kukulitsa. Izi ndi pafupifupi gawo limodzi mwa magawo atatu a chiwerengero chofunikira ndi RT-PCR wamba.

"RT-PCR yodziwika bwino imatengera kuzindikira kwa ma siginecha a fluorescence, kotero maola 3-4 amafunikira kuti azindikire SARS-CoV-2. Kuthamanga kumeneku sikokwanira poganizira momwe COVID-19 imafalira. Tinkafuna kupeza njira yochepetsera nthawiyi pafupifupi theka,” akutero Prof. Jaebum Choo, pofotokoza zomwe zidayambitsa kafukufukuyu. Mwamwayi, yankho silinali patali kwambiri. Pakafukufuku wapitalo lofalitsidwa mu 2021, gulu la Prof. Choo lidapanga nsanja yodziwikiratu momwe ma SERS ali ndi chidwi kwambiri amapangidwa ndi ma AuNPs omwe amalinganizidwa bwino m'mabowo a AuNDS kudzera munjira yotchedwa hybridization. Kutengera zomwe zapezedwa m'mbuyomu, Prof. Choo ndi gulu lake adapanga njira yatsopano ya SERS-PCR yowunikira matenda a COVID-19.

Kuyesa kumene kwa SERS-PCR kumagwiritsa ntchito zizindikiro za SERS kuti azindikire "mlatho wa DNA" -zofufuza zazing'ono za DNA zomwe zimasweka pang'onopang'ono pamaso pa ma jini omwe amawatsata. Chifukwa chake, m'zitsanzo za odwala omwe ali ndi COVID-19, kuchuluka kwa mlatho wa DNA (ndi chifukwa chake chizindikiro cha SERS) kumatsika mosalekeza ndikuzungulira kwa PCR. Mosiyana ndi izi, pamene SARS-CoV-2 palibe, chizindikiro cha SERS chimakhala chosasinthika.

Gululo lidayesa magwiridwe antchito a makina awo pogwiritsa ntchito zolembera ziwiri zoyimilira za SARS-CoV-2, zomwe ndi puloteni ya emvulopu (E) ndi jini yodalira RNA polymerase (RdRp) ya SARS-CoV-2. Ngakhale mizunguliro 25 idafunikira kuti izindikiridwe ndi RT-PCR, nsanja ya SERS-PCR yochokera ku AuNDS idangofunika mizungu 8 yokha, kuchepetsa nthawi yoyesa. "Ngakhale kuti zotsatira zathu ndi zoyambirira, zimapereka umboni wofunikira wa SERS-PCR ngati njira yodziwira matenda. Njira yathu ya SERS-PCR yochokera ku AuNDS ndi njira yatsopano yodziwira ma cell yomwe imatha kufupikitsa nthawi yofunikira kuti izindikire majini poyerekeza ndi njira wamba za RT-PCR. Chitsanzochi chikhoza kukulitsidwanso mwa kuphatikizira chitsanzo chodziwikiratu kuti apange njira yodziwira maselo a m'badwo wotsatira," akufotokoza Prof. Choo.

Zowonadi, SERS-PCR ikhoza kukhala chida chofunikira pagulu lathu lankhondo polimbana ndi mliri wa COVID-19. Zitha kupangitsanso kusintha kwamaganizidwe pazambiri zama cell, kusintha momwe timadziwira matenda opatsirana ndikuthana ndi miliri yamtsogolo.

Sangalalani, PDF ndi Imelo

Ponena za wolemba

mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

Siyani Comment

eTurboNews | | Mbiri ya TravelIndustry