New Key Antidiabetic Drug

Written by mkonzi

Daewoong Pharmaceutical (Daewoong) yatsimikizira zotsatira zowoneka bwino za gawo 3 zomwe zimayang'ana kwambiri pazachirengedwe monga Enavogliflozin monotherapy komanso kuphatikiza mankhwala ndi metformin. Daewoong's Enavogliflozin ndi SGLT-2 inhibitor pakukula koyamba ku Korea. Lipoti laposachedwa lapamwamba limapangitsa kuyembekezera zotsatira zabwino za mayesero achipatala a 3 omwe lipoti lomaliza lidzatulutsidwa mu theka lachiwiri la chaka chino.

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Pulofesa Kyong Soo Park wa ku Seoul National University Hospital monga wofufuza wogwirizanitsa komanso ofufuza akuluakulu ochokera m'mabungwe 22 atenga nawo mbali muyeso lachipatala la gawo 3 la Enavogliflozin monga monotherapy (kafukufuku wa ENHANCE-A). Kafukufukuyu adachitika ngati kuyesa kosiyanasiyana, kosasinthika, kwakhungu kawiri, koyendetsedwa ndi placebo, komanso kutsimikizira kwachipatala komwe kunali ndi odwala 160 omwe ali ndi matenda a shuga a 2. Chomaliza chachikulu chinali kufufuza kusiyana pakati pa gulu la Enavogliflozin ndi gulu la placebo pakusintha koyambirira kwa glycated hemoglobin (HbA1c). Malinga ndi lipoti lapamwamba, lidawoneka kuti linali 0.99% p pa masabata a 24 kuchokera pamene kayendetsedwe ka kafukufukuyu adatsimikizira kufunika kwa chiwerengero (P-value <0.001). HbA1c, chomwe ndi chinthu chomaliza cha hemoglobin cholumikizidwa ndi shuga wamagazi, ndi muyeso wagolide wotsimikizira kuopsa kwa matenda a shuga.

Kuphatikiza apo, panali zotsatira zabwino za kafukufuku zomwe zidawonedwa muyeso lina lachipatala la gawo 3 la kuphatikiza mankhwala a Enavogliflozin ndi metformin ndi Daewoong Pharmaceutical (ENHANCE-M). Kafukufuku wa ENHANCE-M adayendetsedwa ndi Pulofesa Gun Ho Yoon wa The Catholic University of Korea Seoul St. Mary's Hospital monga wogwirizanitsa ofufuza ndi ofufuza akuluakulu ochokera ku mabungwe 23. Kuyesereraku kudachitika ndi odwala 200 omwe ali ndi matenda amtundu wa 2 omwe amalephera kuwongolera shuga wamagazi ndi metformin. Kutengera zotsatira za kusintha koyambira kwa HbA1c. Gulu la odwala omwe adalandira Enavogliflozin ndi Metformin adawonetsa bwino kusakhala pansi kwa gulu lomwe lidaperekedwa nthawi imodzi ndi Dapagliflozin ndi metformin. Zotsatira zachitetezo m'gulu lomwe limayendetsedwa ndi Enavogliflozin zidatsimikizikanso chifukwa panalibe zochitika zosayembekezereka kapena zoyipa zomwe zidachitika.

Ofufuzawo adati, "Mayeso azachipatala a gawo 3 a Enavogliflozin monotherapy (ENHANCE-A) ndi metformin kuphatikiza therapy (ENHANCE-M) okhala ndi anthu 360 aku Korea awonetsa kutsika kwa glucose komanso chitetezo chamankhwala. Enavogliflozin idzakhala njira yabwino kwambiri yothandizira odwala omwe ali ndi matenda a shuga amtundu wa 2 ngati zotsatira zomwezo zitsimikiziridwa ndi njira zina zochiritsira zophatikiza.

Zotsatira zazikulu zidapezedwa m'mayesero onse awiri a monotherapy ndi metformin kuphatikiza mankhwala, Daewoong ali wokondwa kutulutsa choletsa chatsopano cha SGLT-2 kwa nthawi yoyamba ku South Korea. Daewoong akukonzekera nthawi yomweyo kufunsira kuvomerezedwa kwamankhwala atsopanowo ndikuyambitsa osati Enavogliflozin komanso komanso Enavogliflozin/Metformin Fixed-Dose Combination (FDC) pofika chaka cha 2023. FDC ya Enavogliflozin ndi Metformin mu Januware 1.

"Pochita bwino m'mayesero aposachedwa azachipatala, tikuyembekezeka kupatsa odwala am'deralo mankhwala atsopano a shuga mdziko muno posachedwa," atero Sengho Jeon, CEO wa Daewoong Pharmaceutical. "Tiyesetsa kutulutsa mankhwala am'badwo wotsatira ndikuthandizira omwe ali ndi matenda a shuga ndi zovuta, pomwe tikulimbikitsa kukula kwa kampaniyo."

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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