New Ultrasound Stimulation Njira Yothandiza ya Alzheimer's

Written by mkonzi

Matenda a Alzheimer amakhudza anthu opitilira 50 miliyoni padziko lonse lapansi ndipo pano ndi osachiritsika. Njira yothandiza yochizira imaphatikizapo kuchepetsa kuchuluka kwa mapuloteni muubongo ndi mafunde a gamma. Komabe, kafukufuku wotsimikizira zotsatira zake zochiritsira pogwiritsa ntchito ma ultrasound osakhazikika omwe ali ndi gamma entrainment akusowa. Tsopano, asayansi ochokera ku Gwangju Institute of Science and Technology akuwonetsa kuchepa kwa mapuloteni muubongo mwa kulunzanitsa mafunde a muubongo ndi ma ultrasound akunja pama frequency a gamma, ndikutsegula zitseko za chithandizo chosasokoneza.   

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Chifukwa cha kuchuluka kwa zaka zimene anthu amayembekeza kukhala ndi moyo m’madera ambiri padziko lapansi, matenda ena okhudzana ndi ukalamba afala kwambiri. Matenda a Alzheimer (AD), mwatsoka, ndi amodzi mwa iwo, omwe afala kwambiri pakati pa anthu okalamba ku Japan, Korea, ndi mayiko osiyanasiyana a ku Ulaya. Pakali pano palibe mankhwala kapena njira yothandiza yochepetsera kufalikira kwa AD. Chotsatira chake, chimadzetsa kuvutika kochuluka kwa odwala, mabanja, ndi osamalira pamodzi ndi kulemedwa kwakukulu kwachuma.

Mwamwayi, kafukufuku waposachedwapa wa gulu la asayansi pa Gwangju Institute of Science and Technology (GIST) ku Korea wangosonyeza kuti pangakhale njira yothetsera AD pogwiritsa ntchito "ultrasound-based gamma entrainment," njira yomwe imaphatikizapo kulunzanitsa. kukweza mafunde a ubongo wa munthu (kapena nyama) pamwamba pa 30 Hz (otchedwa "mafunde a gamma") ndi kusuntha kwakunja kwafupipafupi. Mchitidwewu umachitika mwachilengedwe powonetsa mutu ku chisonkhezero chobwerezabwereza, monga phokoso, kuwala, kapena kugwedezeka kwa makina.

Kafukufuku wam'mbuyo pa mbewa wasonyeza kuti kulowetsedwa kwa gamma kungathe kulimbana ndi mapangidwe a β-amyloid plaques ndi tau protein accumulations-chizindikiro chodziwika bwino cha chiyambi cha AD. Mu pepala laposachedwa ili, lomwe linasindikizidwa mu Translational Neurodegeneration, gulu la GIST linasonyeza kuti n'zotheka kuzindikira kulowetsedwa kwa gamma pogwiritsa ntchito ma ultrasound pulses pa 40 Hz, mwachitsanzo, mu bandi yafupipafupi ya gamma, mu ubongo wa mbewa za AD-model.

Ubwino wina waukulu wa njira imeneyi ndi mmene umagwiritsidwira ntchito. Pulofesa wina, dzina lake Jae Gwan Kim, amene anatsogolera kafukufukuyu limodzi ndi Wothandizira Pulofesa Tae Kim, anafotokoza kuti: “Poyerekeza ndi njira zina zoloŵetsa madzi a gamma zimene zimadalira maphokoso kapena magetsi amene akuthwanima, mphamvu ya ultrasound imatha kufika ku ubongo popanda kusokoneza ubongo wathu. Izi zimapangitsa kuti njira za ultrasound zikhale zomasuka kwa odwala. ”

Monga momwe zoyesera zawo zidawonetsera, mbewa zomwe zimawululidwa ndi ma ultrasound pulses kwa maola awiri tsiku lililonse kwa milungu iwiri zidachepetsa kuchuluka kwa β-amyloid plaque ndi kuchuluka kwa mapuloteni a tau muubongo wawo. Kuphatikiza apo, kuwunika kwa electroencephalographic kwa mbewa izi kudawonetsanso kusintha kwa magwiridwe antchito, kuwonetsa kuti kulumikizana kwaubongo kumapindulanso ndi mankhwalawa. Komanso, njirayi sinapangitse mtundu uliwonse wa microbleeding (kutaya magazi muubongo), zomwe zikuwonetsa kuti sizinali zovulaza mwa makina a ubongo.

Ponseponse, zotsatira zodalirika za kafukufukuyu zitha kuyambitsa njira zochiritsira zatsopano, zosagwiritsa ntchito mphamvu za AD popanda zotsatirapo zoyipa, komanso kuthandizira kuchiza matenda ena kupatula AD. Dr. Tae Kim anati: “Ngakhale kuti njira yathu ingathandize kwambiri odwala mwa kuchedwetsa kudwala AD, ingaperekenso njira yatsopano yothetsera matenda ena oyambitsa ubongo, monga matenda a Parkinson.”

Tiye tikuyembekeza kuti maphunziro amtsogolo adzakhazikitsa ultrasound-based gamma entrainment ngati njira yothandizira, ndikupereka chithandizo chofunikira kwambiri kwa odwala AD ndi mabanja awo.

 

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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