New immunotherapy yochizira chiponde

A GWIRITSANI KwaulereKutulutsidwa 3 | eTurboNews | | eTN
Avatar ya Linda Hohnholz
Written by Linda Hohnholz

Aravax, kampani yachipatala ya biotechnology yomwe imayang'ana kwambiri pakupanga chithandizo choyamba cha matenda a mtedza omwe adapangidwa kuti akhale otetezeka, ogwira mtima komanso osavuta, lero alengeza kuti yalandira kuwala kobiriwira pakugwiritsa ntchito kwake Investigational New Drug (IND) kuchokera ku US Food and Drug Administration (FDA).

PVX108 ndi m'badwo wotsatira, allergen-specific immunotherapy pogwiritsa ntchito ma peptides omwe amayimira tizidutswa tating'ono ta mapuloteni a mtedza kuti athe kulunjika bwino ma cell a T omwe amayendetsa kusagwirizana kwa mtedza. Mankhwalawa amaperekedwa kamodzi pamwezi, amapangidwa kuti apangitse kulolerana kwa protein ya peanut popanda chitetezo choletsa kugwiritsa ntchito njira yokhayo yolembetsedwa yomwe imagwiritsa ntchito zotulutsa zachilengedwe kuchokera ku mtedza. Kukhalapo kwa zinthu zonse zomwe zimaletsa chiponde m'zigawozi zimayika odwala pachiwopsezo chachikulu cha anaphylaxis (Chu et al. The Lancet 2019).

IND idzalola Aravax kuti apititse patsogolo pulogalamu yoyeserera yachipatala ya Phase 2 ku US ndikukulitsa ntchito zake padziko lonse lapansi.

"Ndife okondwa kugawana kuti FDA yalola Aravax kuyambitsa kafukufuku wa Phase 2 kuti adziwe mlingo woyenera wa PVX108 mwa ana omwe ali ndi vuto la mtedza ku United States. Awa ndi malo achirengedwe osasungidwa bwino, ndipo tikukhulupirira kuti njira yathu ili ndi zabwino zambiri kuposa chithandizo chomwe chilipo ndi njira yake yeniyeni yochitira zinthu komanso mbiri yachitetezo yomwe yatsimikiziridwa kale m'mayesero azachipatala a Gawo 1. " Anatero CEO wa Aravax, Dr Pascal Hickey.

M'mbuyomu, mayesero a Phase 1 osasinthika, akhungu awiri, omwe amayendetsedwa ndi placebo mwa akuluakulu a 66 peanut-allergic (AVX-001) sanasonyeze umboni wa zochitika zovuta zachipatala. Kuphatikiza apo, maphunziro a ex vivo omwe amapereka muyeso wokhazikika wachitetezo (basophil activation) mu 185 opereka magazi a mtedza-osagwirizana nawo adatsimikizira kusowa kwa basophil reactivity ku PVX108 mosiyana ndi peanut extract. Izi zikuwonetsa kuti PVX108 ili ndi chitetezo chabwino kwambiri pochiza odwala omwe ali ndi vuto la mtedza, kuphatikiza omwe ali ndi ziwengo kwambiri.

Patent yoyamba ya Aravax yokhudzana ndi kapangidwe ka PVX108 idaperekedwanso ku US, EU ndi madera ena. Mabanja owonjezera ovomerezeka nawonso akuyenda bwino m'malo awa.

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Avatar ya Linda Hohnholz

Linda Hohnholz

Mkonzi wamkulu kwa eTurboNews zochokera ku eTN HQ.

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