Kufikira Kwatsopano ku Platform Monitoring Cancer

A GWIRITSANI KwaulereKutulutsidwa 5 | eTurboNews | | eTN
Avatar ya Linda Hohnholz
Written by Linda Hohnholz

Invitae lero yalengeza mwayi wonse wa nsanja yake ya Personalized Cancer Monitoring (PCMTM) kuti ithandizire kuzindikira matenda ochepa kapena otsalira a maselo (MRD) mwa odwala omwe ali ndi zotupa zolimba. Invitae PCM imagwiritsa ntchito mndandanda wazoyeserera wamunthu payekhapayekha potengera chotupa cha wodwala kuti azindikire chotupa cha DNA (ctDNA) m'magazi, ndikupereka kuthekera kopanga chiwopsezo, kuwunika momwe angayankhire chithandizo ndikuzindikira kuti khansa iyambiranso, kutengera kafukufuku waposachedwa.

"Kuchepetsa chiopsezo chobwereranso ndikofunikira kwa odwala ambiri omwe akulandira chithandizo cha zotupa zolimba ndipo amathandizidwa bwino ndi zida zaposachedwa za mamolekyulu kuti zithandizire ndikuwongolera njira zosamalira kuti zizindikiridwenso," atero a Robert Nussbaum, MD, wamkulu. dokotala, Invitae. "Pulatifomu ya PCM imakwaniritsa njira zowunikira zomwe zikuchitika, ndipo imatha kudziwa momwe chithandizo cha khansa chimagwirira ntchito kale kuposa njirazo kwa odwala ambiri, zomwe zimapatsa madokotala mwayi wokonza njira zamankhwala."

Kwa zaka zingapo zapitazi, kafukufuku wochokera ku Invitae ndi gulu lalikulu la asayansi, kuphatikizapo kafukufuku wa TRACERx wotsogoleredwa ndi Pulofesa Charles Swanton ku Francis Crick Institute ndi University College London (UCL), ndipo mothandizidwa ndi Cancer Research UK, wasonyeza kuti kuwunika kwa MRD kungatheke. zindikirani modalirika odwala khansa ya m'mapapo omwe ali pachiwopsezo choyambiranso, kuzindikira kuyambiranso pambuyo pa opaleshoni nthawi zambiri kuposa momwe amaganizira, kuwunika momwe akuyankhira, ndikukhala ngati wolowa m'malo omaliza mayeso azachipatala. Ndi mphamvu izi, kuwunika kwa MRD kumalonjeza kufupikitsa mayesero azachipatala ndikufulumizitsa kupanga mankhwala atsopano omwe angapulumutse moyo. Invitae PCM ndi pan-cancer, chotupa chodziwitsa zamadzimadzi biopsy assay, yopangidwa ndi TRACERx consortium, yomwe imagwiritsa ntchito mibadwo yotsatira (NGS) kusanthula ctDNA mu plasma ya wodwala.

"MRD ndi biomarker yofunika kwambiri pa nthawi ya adjuvant ndi surveillance," anatero Pulofesa Charles Swanton, MBPhD, FRCP, FMedSci, FRS, FAACR, ku Francis Crick Institute ndi UCL Cancer Institute ndi Chief Clinician of Cancer Research UK. "Monga tawonera mu kafukufuku wa TRACERx, PCM imapereka zidziwitso zam'tsogolo, imatha kuthandizira pazovuta za radiographic, ndikuwonetsa chidwi chambiri komanso kutsimikizika kwachipatala."

Mayeso amadzimadzi a biopsy akhala akupezeka posankha chithandizo, koma kuti azindikire MRD msanga kuposa njira wamba odwala asanabwerere m'mbuyo, ukadaulo uyenera kukhala watcheru kuti uzindikire ctDNA pamilingo yotsika kwambiri. Kuphatikiza apo, kuyezetsa kwa MRD kodziwika bwino kumafunikanso kuti muchepetse mwayi wopeza zotsatira zabodza. Kuyesa kwa PCM kumagwiritsa ntchito matekinoloje apamwamba kuti afike pamlingo wokhudzika komanso wodziwika bwino, kuzindikira chotupa cha DNA pamilingo yotsika kwambiri yamagazi am'magazi. Kafukufuku wotsimikizira akuwonetsa kukhudzika kwakukulu kopitilira 99.9% pakuzindikira ctDNA pamlingo wa 0.008% wosiyanasiyana.

"Ndife okondwa ndi kupezeka kwa PCM padziko lonse lapansi, chifukwa iyi ndi malo omwe tidayikapo ndalama chaka chathachi ndipo tikukhulupirira kuti tili ndi mwayi wopatsa odwala chidziwitso chofunikira kuti amvetsetse kuopsa kwawo kuti athe kulimbana ndi kumenya matendawa," adatero Sean. George, Ph.D., woyambitsa nawo limodzi ndi CEO wa Invitae.

Kuyesa kulikonse kumapangidwira kuti azindikire chotupa chapadera cha wodwala, kulola zotsatira zamunthu kuti zitsogolere zisankho zachipatala. Invitae PCM imafuna zitsanzo zamagazi ndi zotupa kuchokera kwa wodwala kuti azichita chotupa-normal exome sequencing (WES). Kutengera zotsatira, Invitae's proprietary algorithm imasankha mitundu 18-50 ya chotupa kuti iziphatikize pagulu la ctDNA lopangidwa ndi wodwala. Mitundu yosiyanasiyana iyi imalola kuti pakhale kudziwika kwachangu komanso kodziwika bwino kwa MRD m'makhansa omwe ali ndi zolemetsa zochepa kapena zapamwamba.

Ngati zotsatira za MRD zabwino zimapezeka nthawi iliyonse paulendo wa wodwala khansa, dokotala ndi wodwala akhoza kukambirana zotsatira za zotsatira zake ndi chithandizo choyenera kwambiri kapena njira zoyesera zachipatala. "Kudziwa kwa ma cell kumakhudza odwala khansa paulendo wawo wonse wa khansa, zomwe zimapangitsa kuti izi zikhale zofunika kwambiri pazamankhwala," adatero George.

Invitae ikukulitsa ntchito zofufuzira padziko lonse lapansi kuti apitilize kusonkhanitsa zambiri pazachipatala za PCM komanso maphunziro otsogozedwa ndi MRD. Invitae akuyembekeza zofalitsa zambiri chaka chino pamaphunziro ake a PCM m'mapapo, m'mawere, mutu ndi khosi, ndi zotupa za GI komanso maphunziro angapo omwe akuyembekezeka kuyambika mu theka loyamba la chaka. Maphunziro omwe akuyembekezeka akuphatikizapo kafukufuku wa pan-tumor (MARIA) ndi maphunziro angapo a khansa ya m'mawere ndi GI, kuphatikiza ARTEMIS, kafukufuku wofufuza Invitae's PCM yopereka makamaka kwa odwala khansa ya kapamba. Phunziroli lidzachitidwa mogwirizana ndi malo apamwamba omwe ali pafupi ndi Tokyo, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. Zosonkhanitsa zitsanzo zidzayamba mu Q2 2022.

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Avatar ya Linda Hohnholz

Linda Hohnholz

Mkonzi wamkulu kwa eTurboNews zochokera ku eTN HQ.

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