Chithandizo cha alopecia chimapulumutsa 80% ya tsitsi

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Written by Linda Hohnholz

Akuluakulu ndi zovuta alopecia areata (AA) yemwe adatenga OLUMIANT® (baricitinib) adapindula kwambiri pamutu, nsidze ndi tsitsi la nsidze ndipo pafupifupi 75% mwa omwe adayankha OLUMIANT 4-mg adapeza 90% kuphimba khungu pa masabata a 52, Eli Lilly ndi Company ndi Incyte adalengeza lero. pa Msonkhano Wapachaka wa American Academy of Dermatology (AAD). Mu February 2022, US Food and Drug Administration (FDA) idapereka kuwunika kwa OLUMIANT mu AA yovuta ngati mankhwala omwe angakhale oyamba kudwala. Lilly akuyembekeza zisankho zowongolera ku US, European Union ndi Japan mu 2022.

Pakuwunika kophatikizana kwa milungu 52, odwala omwe ali pachiwopsezo anali ndi Kuvuta Kwambiri kwa Chida cha Alopecia (SALT) chiwerengero cha 85.5 (85.5% kutayika tsitsi, kapena 14.5% kuphimba tsitsi); AA yoopsa imatanthauzidwa kukhala ndi chiwerengero cha SALT ≥50 (≥50% kutayika tsitsi lamutu). Pachiyambi, 69.4% ndi 57.9% anali ndi nsidze zazikulu ndi tsitsi la nsidze, motero, monga momwe amafotokozera Clinician-Reported Outcome (ClinRO) scores ≥2. Avereji ya zaka za odwala inali zaka 37.6, tsitsi limatha kuyambira zaka 25 ndipo pafupifupi zaka 12.2 chiyambireni zizindikirozo.

Pakati pa odwala omwe adatenga OLUMIANT 4-mg, awiri mwa asanu (39.0%, n = 201 / 515) adapezanso tsitsi lamutu, lomwe limatanthauzidwa ngati SALT score ≤20, kapena 80% kapena kupitirira tsitsi la scalp, ndi pafupifupi atatu kunja. mwa anayi mwa odwalawo (74.1%, n = 149/201) adapezanso chiwerengero cha SALT ≤10, kapena 90% kuphimba tsitsi, pa masabata a 52. Payokha, odwala opitilira awiri mwa asanu omwe ali ndi zoyambira za ClinRO ≥2 (nsidze: 44.1%, n = 154/349; nsidze: 45.3%, n = 139/307) adawona kukula kwathunthu kapena kukuliranso komwe kumakhala ndi mipata yaying'ono mu nsidze ndi nsidze. tsitsi.

Mwa odwala omwe adatenga OLUMIANT 2-mg, opitilira m'modzi mwa asanu (22.6%, n = 77/340) adakulanso tsitsi lamutu ndipo awiri mwa atatu mwa odwalawo (67.5%, n = 52/77) adapeza 90. % kapena kuphimba tsitsi kupitilira pa masabata 52. Payokha, oposa mmodzi mwa asanu ndi mmodzi mwa odwala anayi, motero (nsidze: 22.9%, n = 55/240; nsidze: 25.5%, n = 51/200), adawona kukula kwathunthu kapena kuyambiranso ndi mipata yochepa mu nsidze ndi nsidze. tsitsi.

Kusanthula kophatikizana kwa milungu 52 kukuwonetsa kupitilirabe kukula kwa tsitsi, nsidze ndi nsidze kuchokera pazotsatira zamasabata 36 zomwe zasindikizidwa lero mu New England Journal of Medicine ndikuperekedwa ku 2021 European Academy of Dermatology and Venereology (EADV) Congress.

“Kaya anthu omwe ali ndi vuto la alopecia areata amathothoka tsitsi lonse pathupi lawo kapena madontho komanso kusowa nsidze kapena nsidze, matendawa amatha kukhala oopsa kwambiri. Matendawa amakhudza anthu a mibadwo yonse, "anatero Brett King, MD, Ph.D., FAAD, pulofesa wothandizira dermatology ku Yale School of Medicine ndi wolemba wamkulu wa kusanthula kumeneku. "Mu 2022, OLUMIANT adakhala mankhwala oyamba kuvomerezedwa kuchiza alopecia areata. Ndizodabwitsa kuti pafupifupi 40% ya odwala omwe ali ndi OLUMIANT 4-mg, onse omwe adayamba ndi 50% kutayika tsitsi lapamutu, anali ndi tsitsi lathunthu kapena pafupifupi lathunthu, ndipo kusintha komweku kunachitika pakati pa odwala omwe ali ndi nsidze kapena nsidze. kukhudzidwa."

Pakuwunika kwa OLUMIANT 4-mg ndi 2-mg chitetezo chanthawi yayitali, kuchuluka kwa zochitika zomwe zimanenedwa pafupipafupi mpaka masabata a 52 (kuwonetseredwa kwapakati pa masabata 56) zinali zogwirizana ndi masabata a 36, ​​nthawi yoyendetsedwa ndi placebo ndikuphatikiza kupuma kwapamwamba. matenda a thirakiti, mutu, ziphuphu zakumaso, matenda a mkodzo ndi kuwonjezeka kwa zizindikiro za magazi zokhudzana ndi minofu. Panalibe zizindikiro zatsopano zachitetezo.

“Kafukufuku wa OLUMIANT wa nthawi yaitali akusonyeza kuti tsitsi la m’mutu, la m’kope ndi la m’nsidze layamba kumeranso ndipo ndife okondwa ndi zimene zotsatirazi zingatanthauze odwala. Deta yathu yachitetezo cha alopecia areata imawonjezera umboni wina ku imodzi mwazinthu zazikulu komanso zazitali kwambiri zachitetezo mu kalasi ya JAK inhibitor, kuphatikiza zaka zisanu ndi zinayi ndi zaka 19,000 za odwala pulogalamu yathu yonse, "anatero Lotus Mallbris, MD, Ph.D., wachiwiri kwa purezidenti. za chitukuko cha immunology padziko lonse lapansi ndi nkhani zachipatala ku Lilly. "Ndife okondwa kuti OLUMIANT ikhoza kukhala mankhwala oyamba kudwala omwe avomerezedwa chaka chino kwa akuluakulu omwe ali ndi vuto la alopecia areata."

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Avatar ya Linda Hohnholz

Linda Hohnholz

Mkonzi wamkulu kwa eTurboNews zochokera ku eTN HQ.

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