Kulonjeza Chithandizo Chatsopano Chatsopano cha Cancer Gastric Cancer/GEJ Cancer

A GWIRITSANI KwaulereKutulutsidwa 2 | eTurboNews | | eTN
Avatar ya Linda Hohnholz
Written by Linda Hohnholz

Trishula Therapeutics, Inc. lero yalengeza zotsatira zoyambirira kuchokera ku kuyesa kwa Gawo 1 komwe kukuyesa TTX-030 kuphatikiza budigalimab (investigalimab anti-PD-1) ndi FOLFOX pochiza odwala omwe ali ndi vuto la m'mimba / metastatic HER2 kapena. khansa ya m'mimba ya gastroesophageal. Zotsatira za phunziroli zidaperekedwa m'chiwonetsero chapakamwa pa Msonkhano Wapachaka wa American Association for Cancer Research (AACR) ku New Orleans. Deta yomwe idaperekedwa ikuwonetsa kuti chithandizo chophatikiza cha TTX-030 nthawi zambiri chimaloledwa bwino ndipo chimawonetsa zizindikiro zolimbikitsa za anti-chotupa.

"Kuyankha kwa odwala omwe ali ndi zotupa zotsika za PD-L1 zomwe zawonedwa pakuwunika koyambiriraku ndizolimbikitsa kwambiri komanso zimathandizira kuthekera kwa TTX-030 kuti ikhudze chisamaliro cha odwala omwe ali ndi khansa ya m'mimba ndi gastroesophageal," adatero Zev Wainberg, MD. Pulofesa wa Zamankhwala ku UCLA komanso wotsogolera wa UCLA GI Oncology Program. "Tikuyembekeza zonse zomwe tapeza kuchokera ku mayeserowa komanso kupititsa patsogolo njira yodalirika ya chithandizo ichi."

Zotsatira zoyamba zogwira ntchito ndi chitetezo zinaperekedwa monga kudulidwa kwakanthawi kochepa pa Marichi 1, 2022. Odwala 44 onse adalembetsa. Odwala makumi awiri ndi zisanu ndi chimodzi (26) anali adakali pa chithandizo cha maphunziro, ndipo nthawi yapakati pa phunziro inali masiku 214 (masiku 8-464+). Pakati pa odwala 40 omwe amatha kuyesedwa bwino, odwala 21 (odwala 25 kuphatikizapo osatsimikiziridwa) adapindula bwino kwambiri poyankha pang'onopang'ono kapena bwino kuphatikizapo 4 CRs: ORR = 52.5% (62,5% kuphatikizapo osatsimikiziridwa), ndi chiwerengero cha matenda = 92.5%. Odwala makumi atatu mphambu asanu ndi awiri (37) mwa odwala omwe ayesedwa bwino adadziwa PD-L1 Combined Positive Score (CPS); kuyankha kwa odwala omwe ali ndi CPS ≥1 anali 65% (77% kuphatikiza osatsimikiziridwa).

Odwala makumi awiri mphambu asanu ndi awiri a 44 (61%) adakumana ndi vuto limodzi (AE) la kalasi iliyonse yokhudzana ndi TTX-030 (kuwunika kwa ofufuza), kuphatikizapo odwala 9 (20.5%) omwe ali ndi Giredi 3/4 AEs. Zochitika zoyipa zinali zogwirizana ndi zomwe zimawonedwa ndi chisamaliro chokhazikika (chemotherapy kuphatikiza anti-PD-1).

"Zomwe tafotokoza ku AACR zikuyimira zotsimikizira zoyambirira za anti-CD39 antibody mwa odwala omwe ali ndi khansa ya m'mimba ndipo zimathandizira ntchito ya TTX-030 pochotsa adenosine-mediated immunosuppression," adatero Anil Singhal, Chief Executive Officer. "Tikuyembekezera kupita patsogolo kwa kafukufuku wazachipatala wa TTX-030, yemwe tikukhulupirira kuti atha kupititsa patsogolo chithandizo chamankhwala kwa odwala khansa."

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Linda Hohnholz

Mkonzi wamkulu kwa eTurboNews zochokera ku eTN HQ.

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