Kodi Psychedelics Ndiwo Ma antidepressants Atsopano?

Matenda a nkhawa ndi matenda amisala omwe amapezeka kwambiri ku US, omwe amakhudza akuluakulu pafupifupi 40 miliyoni chaka chilichonse, ndipo ngakhale pali kuchuluka kwa mankhwala oletsa kuda nkhawa omwe amapezeka, kukana chithandizo kumachitika pafupifupi 30% ya odwala. Matenda a nkhawa ali ndi vuto lalikulu pazachuma pazachipatala ku US, zomwe zimawononga pakati pa $42.3 biliyoni ndi $46.6 biliyoni pachaka, kutanthauza kuti ndikofunikira kupeza njira zina zothandizira. Mwamwayi, kafukufuku watsopano akuwonetsa kuti psychedelics ikhoza kukhala yankho. Zotsatira za mayeso azachipatala zikuwonetsa kuti psilocybin, psychedelic wamphamvu, imakhala ndi zotsatira zopondereza kwa odwala omwe ali ndi kupsinjika maganizo ndipo imakhala yothandiza kwambiri kuposa escitalopram. Zachidziwikire, iyi ndi imodzi mwamaphunziro opambana ambiri okhudzana ndi kugwiritsa ntchito psychedelics ngati chithandizo cha matenda amisala.

Cybin Inc imayang'ana kwambiri kupititsa patsogolo ma psychedelics muzachirengedwe popanga nsanja zopezera mankhwala, njira zatsopano zoperekera mankhwala, njira zopangira zatsopano komanso njira zochizira matenda amisala.

Pa Epulo 13, Cybin adalengeza zabwino za CYB004 preclinical data kuchokera ku kafukufuku wa pharmacokinetic wowunika ma molekyulu ake a deuterated dimethyltryptamine (DMT), CYB004, yoyendetsedwa ndi mpweya. Makamaka, CYB004 yopumira idawonetsa zabwino zambiri kuposa DMT yolowetsedwa m'mitsempha komanso yopumira, kuphatikiza nthawi yayitali yochitapo kanthu komanso kusinthika kwa bioavailability. Kafukufukuyu adawonetsanso kuti CYB004 yopumira inali ndi chiyambi chofananira ndi mbiri ya mlingo ku IV DMT. Deta iyi ikhoza kuthandizira kuthekera kwa kutulutsa mpweya ngati njira yabwino komanso yoyendetsedwa bwino yoperekera chithandizo chamankhwala a psychedelics. Cybin pakali pano akupanga CYB004 yochizira matenda a nkhawa. Kampaniyo ikuyembekeza kuyika fayilo yoyendetsera kafukufuku woyendetsa gawo lachiwiri la 2022 ndikuyambitsa maphunziro oyendetsa gawo lachitatu.

"M'kafukufuku wambiri, DMT yawonetsa kuti ndi yodalirika komanso yothandiza pochiza matenda amisala. Komabe, zotsatira zodziwika bwino monga kusokonezeka maganizo ndi nkhawa komanso kasamalidwe kake zalepheretsa kugwiritsidwa ntchito kwake ndi kupezeka kwake. CYB004 kudzera pokoka mpweya imatha kuthetsa zovutazi ndipo pamapeto pake imathandizira njira yachipatala yopita patsogolo pamankhwala ofunikirawa. Monga gawo la ntchito yonse ya Cybin yopanga mankhwala ochiritsira otetezeka komanso ogwira mtima a psychedelic, CYB004 yopumira ikupangidwa kuti igonjetse malire a IV DMT ndikukhala njira yofunikira yothandizira odwala ndi madokotala," adatero Doug Drysdale, CEO wa Cybin. .

Pa Epulo 8, Cybin adalengeza kutulutsidwa kwa pulogalamu yapatent padziko lonse lapansi yokhudzana ndi njira zoperekera mpweya wa mamolekyu angapo a psychedelic, kulimbikitsanso udindo wa Cybin's intellectual property (IP). Pulogalamu ya PCT idzalola Cybin kufunafuna chitetezo cha IP cha mitundu ingapo yopumira ya mamolekyu a psychedelic omwe pano akufufuzidwa ndikupangidwa ndi kampaniyo komanso mamolekyu ena a psychedelic omwe angapangidwe mtsogolo.

"Kusindikizidwa kwa pulogalamu ya patent iyi ya PCT kukuwonetsa kudzipereka kwathu kuti tipeze ndikukhazikitsa njira zatsopano zochizira matenda a psychedelic, kuphatikiza pakuzindikiritsa ndi kuphatikiza njira zoperekera zoperekera zomwe zingawongoleredwe bwino komanso zoyendetsedwa bwino ndi ofuna kuchipatalawa," adatero Doug Drysdale. "Kuphatikiza apo, kupita kwathu patsogolo kuti tipeze IP kuti tipeze njira zapadera zoperekera psychedelic kumagwirizana kwambiri ndikuthandizira pulogalamu yathu yapaipi ya CYB004 ya deuterated DMT kudzera mu inhalation, yomwe cholinga chake ndi kuthana ndi zovuta zina zodziwika za DMT yoyendetsedwa ndi IV."

Cybin adalengeza pa Marichi 31 kuti kafukufuku wake wotheka pogwiritsa ntchito ukadaulo wa Kernel Flow adachita ulendo wawo woyamba. Cholinga chachikulu cha kafukufukuyu ndikuwunika zomwe wophunzirayo adachita atavala Kernel Flow ali ndi chidziwitso chosinthika potsatira ketamine. Ophunzira adzalandira mlingo wochepa wa ketamine kapena placebo atavala Flow headset, yomwe ili ndi masensa apamwamba kwambiri kuti alembe zochitika za muubongo ndipo adzafotokozera zomwe akumana nazo pogwiritsa ntchito mafunso okonzedwa bwino komanso zowunikira zovomerezeka panthawi yophunzira komanso potsatira. Phunziro la milungu inayi lidzayesanso ntchito za ubongo musanayambe komanso pambuyo popereka othandizira ophunzirira - ketamine yotsika kwambiri kapena placebo.