Kafukufuku Watsopano Akufotokoza Chifukwa Chake COVID-19 Imachititsa Kutaya Kwa Fungo

KUGWIRITSA KWAULERE | eTurboNews | | eTN
Avatar ya Linda Hohnholz
Written by Linda Hohnholz

Lofalitsidwa pa intaneti pa February 2 m'magazini ya Cell, kafukufuku watsopanoyu adapeza kuti matenda omwe ali ndi kachilombo ka mliri, SARS-CoV-2, amatsitsa mosadukiza zochita za olfactory receptors (OR), mapuloteni pama cell a mitsempha m'mphuno yomwe imazindikira. mamolekyu ogwirizana ndi fungo. 

Motsogozedwa ndi ofufuza ochokera ku NYU Grossman School of Medicine ndi Columbia University, kafukufuku watsopanoyu atha kuwunikiranso zotsatira za COVID-19 pamitundu ina ya ma cell aubongo, komanso zotsatira zina za minyewa za COVID-19 monga "chifunga chaubongo," mutu, ndi kuvutika maganizo.

Kuyesera kunawonetsa kuti kukhalapo kwa kachilomboka pafupi ndi ma cell a minyewa (ma neuron) mu minofu yamafuta kumabweretsa kuthamangitsidwa kwa ma cell a chitetezo chamthupi, ma microglia ndi ma T cell, kuzindikira komanso kutsutsa matenda. Maselo oterowo amatulutsa mapuloteni otchedwa ma cytokines omwe anasintha chibadwa cha maselo a minyewa ya olfactory, ngakhale kachilomboka sikangathe kuwapatsira, atero olemba kafukufukuyu. Kumene chitetezo cell ntchito akanatha mofulumira mu zochitika zina, mu ubongo, malinga ndi chiphunzitso gulu, chitetezo chizindikiro amalimbikira m'njira amachepetsa ntchito za majini zofunika kuti kumanga olfactory zolandilira.

Kusintha kwa Zomangamanga

Chizindikiro chimodzi chapadera cha matenda a COVID-19 ndikutaya fungo popanda mphuno yodzaza ndi matenda ena monga chimfine, ofufuza akutero. Nthawi zambiri, kununkhira kumatenga milungu ingapo, koma kwa odwala opitilira 12 peresenti ya odwala a COVID-19, kusagwira bwino ntchito kwamafuta kumapitilira munjira yochepetsera kununkhira kosalekeza (hyposmia) kapena kusintha momwe munthu amawonera. fungo lomwelo (parosmia).

Kuti tidziwe za kutayika kwa fungo lochokera ku COVID-19, olemba pano adafufuza zotsatira za ma cell a matenda a SARS-CoV-2 mu hamster zagolide komanso minofu yonunkhira yotengedwa kuchokera ku ma autopsies 23 a anthu. Hamster amaimira chitsanzo chabwino, pokhala nyama zoyamwitsa zomwe zimadalira kwambiri kununkhira kusiyana ndi anthu, komanso zomwe zimagwidwa ndi matenda a m'mphuno.

Zotsatira za kafukufukuyu zimatengera zomwe zidapezeka kwa zaka zambiri kuti njira yomwe imasinthira majini imakhudza maubwenzi ovuta a 3-D, pomwe magawo a DNA amatha kupezeka mosavuta ndi makina owerengera majini a cell potengera zizindikiro zazikulu, komanso pomwe unyolo wina wa DNA umatuluka. kuzungulira kupanga kuyanjana kwautali komwe kumathandizira kuwerenga kokhazikika kwa majini. Majini ena amagwira ntchito mu "zipinda" za chromatin - mapuloteni omwe amakhala ndi majini - omwe amakhala otseguka komanso achangu, pomwe ena amakhala ophatikizika komanso otsekedwa, monga gawo la "zomangamanga za nyukiliya."

Pakafukufuku wapano, zoyeserera zidatsimikizira kuti matenda a SARS-CoV-2, komanso momwe chitetezo chamthupi chimagwirira ntchito, amachepetsa kuthekera kwa maunyolo a DNA mu ma chromosome omwe amakhudza mapangidwe a olfactory receptor nyumba kukhala yotseguka komanso yogwira ntchito, komanso kuzungulira kuti ayambitse. gene expression. Mu minofu yonse ya hamster ndi neuronal yamunthu, gulu lofufuza lidazindikira kupitilirabe komanso kufalikira kwa nyumba zolandirira zolandirira. Ntchito ina yolembedwa ndi olemba awa ikuwonetsa kuti ma neurons onunkhira amalumikizidwa kumadera ovuta aubongo, komanso kuti machitidwe a chitetezo chamthupi m'mphuno amatha kukhudza malingaliro, komanso kuganiza bwino (kuzindikira), kogwirizana ndi COVID yayitali.

Kuyesa kwa ma hamster komwe kunalembedwa pakapita nthawi kunawonetsa kuti kutsika kwa ma olfactory neuron receptors kunapitilira pambuyo pakusintha kwakanthawi kochepa komwe kungakhudze kununkhira kwachilengedwe. Olembawo akuti izi zikuwonetsa kuti COVID-19 imayambitsa kusokonezeka kwanthawi yayitali pakuwongolera kwa jini, kuyimira mtundu wa "nyukiliya kukumbukira" komwe kumatha kulepheretsa kubwezeretsedwa kwa OR kusindikiza ngakhale SARS-CoV-2 itachotsedwa.

Mu sitepe yotsatira, gululi likuyang'ana ngati kuchitira ma hamster okhala ndi COVID yayitali yokhala ndi ma steroids kungaletse kuwononga chitetezo chamthupi (kutupa) kuteteza kamangidwe ka nyukiliya. 

Ponena za wolemba

Avatar ya Linda Hohnholz

Linda Hohnholz

Mkonzi wamkulu kwa eTurboNews zochokera ku eTN HQ.

Amamvera
Dziwani za
mlendo
0 Comments
Zolowetsa Pamakina
Onani ndemanga zonse
0
Mukufuna malingaliro anu, chonde yankhani.x
Gawani ku...