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Wodwala Woyamba Kumwedwa mu Phunziro la Renal Cancer

Written by mkonzi

Telix Pharmaceuticals Limited lero yalengeza kuti wodwala woyamba adamwedwa mu kafukufuku wa 'STARLITE 2' Phase II wa Company's investigational renal cancer therapy, TLX250 (177Lu-DOTA-girentuximab), ku Memorial Sloan Kettering Cancer Center (MSK) ku New York. .               

STARLITE 2 (NCT05239533) idzawunika mphamvu ya TLX250 yowunikira ma radiation kuphatikiza ndi immunotherapy for clear cell renal cell carcinoma (ccRCC), mtundu wodziwika bwino komanso wowopsa wa khansa ya impso. TLX250 imayang'ana carbonic anhydrase IX (CA9), [1] puloteni yomwe imawonetsedwa kwambiri mwa odwala omwe angasonyeze kuyankha kochepa ku immunotherapy ya khansa.[2] Lingaliro ndilakuti milingo yotsika ya radiation yomwe imayang'aniridwa imatha kuthana ndi kukana kwa chitetezo chamthupi - kapena "immune prime" chotupa motero chimapangitsa kuti chikhale chogwirizana ndi khansa ya immunotherapy.

Kafukufuku wa Gawo Lachiwirili, mwa odwala omwe apita patsogolo kutsatira immunotherapy isanachitike, adzawunika ma radiation operekedwa ndi TLX250 kuphatikiza anti-PD-1[3] immunotherapy Opdivo®[4] (nivolumab). Chomaliza chachikulu ndikuzindikira chitetezo ndi mphamvu ya mankhwala ophatikizika ndi TLX250 monga momwe amawunikiridwa ndi zotupa zomwe zimayankhira chithandizo cha Telix motsutsana ndi mulingo waposachedwa wa chisamaliro chokha. Telix's investinion companion imaging agent TLX250-CDx (89Zr-DFO-girentuximab) idzagwiritsidwanso ntchito mu phunziroli kuti iwonetse mawonekedwe a CA9. Kafukufuku wotsogozedwa ndi wofufuza wa mkono umodzi akuyembekezeka kulembetsa odwala pafupifupi 30.

Dokotala wamkulu wa Telix, Dr. Colin Hayward adanena kuti, "Kuphatikizana kwamankhwala olondola a nyukiliya ndi oncology yachipatala kukuchitika ndipo Telix ali patsogolo pa gululi kuti apange mankhwala opangidwa ndi munthu payekha komanso ma regimens othandiza odwala. Tikufuna kuthokoza Dr. Darren Feldman ndi gulu lake lachipatala, komanso odwala omwe angathandize kuti phunziroli likhale losavuta.

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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