Matenda a Alzheimer's: Zotsatira Zabwino mu Chithandizo Chatsopano

Hoth Therapeutics, Inc., kampani ya biopharmaceutical yomwe imayang'ana odwala, lero yalengeza za umboni wamalingaliro opangidwa pogwiritsa ntchito mbewa ya matenda a Alzheimer's, kuthandizira kuthekera kwachire kwa HT-ALZ. Kafukufukuyu adachitika ngati gawo la mgwirizano wa Sponsored Research Agreement ndi yunivesite ya Washington ku St. HT-ALZ ndi njira yochizira yomwe ikukula pansi pa 505 (b) (2) njira yoyendetsera chithandizo cha matenda a dementia okhudzana ndi matenda a Alzheimer's (AD).

AD ndi matenda a neurodegenerative omwe amadziwika ndi kuphatikizika kwa zolembera za amyloid β (Aβ) ndi ma neurofibrillary tangles a mapuloteni a Tau muubongo, omwe amathandizira kuzizindikiro zachipatala za matendawa monga dementia. Kuyesa koyambirira, kochitidwa ndi Carla Yuede, PhD, Pulofesa Wothandizira wa Psychiatry, ndi John Cirrito, PhD, Pulofesa Wothandizira wa Neurology, ku Washington University School of Medicine, adayang'ana pakufufuza zotsatira za HT-ALZ yoperekedwa pakamwa kuti achepetse kuchuluka kwa Aβ mu ubongo interstitial fluid, pogwiritsa ntchito mbewa yokhazikika ya Alzheimer's Disease (wazaka APP/PS1+/- mbewa). Deta yoyambirira yochokera ku maphunzirowa ikuwonetsa kuchepa kwakukulu kwa Aβ mu APP/PS1 +/- mbewa zachimuna ndi zazikazi pambuyo pa chithandizo chamankhwala chowopsa ndi HT-ALZ, poyerekeza ndi nyama zokhala ndi placebo komanso milingo yoyambira ya Aβ, kuthandizira kuti HT-ALZ ili ndi kuthekera. kusintha mapangidwe a Aβ muubongo ndikupangidwa ngati chithandizo cha AD.

"Zotsatira zabwino zonse za maphunzirowa ndi sitepe yoyamba koma yaikulu pa chitukuko cha HT-ALZ monga mankhwala a Alzheimer," anatero Stefanie Johns, Chief Scientific Officer wa Hoth Therapeutics, Inc. "HT-ALZ ndi chithandizo chapadera chapadera. mu AD malo otukuka chifukwa ndi oyenera kupititsa patsogolo chitukuko pansi pa njira ya 505 (b) (2), kuphatikizapo deta yotetezedwa yomwe ilipo. Izi zimathandiza Hoth kuti azitha kuyeserera mwachangu ndikubweretsa chithandizo chatsopano kwa odwala omwe ali ndi matenda a Alzheimer's.

"Zotsatira za mayeserowa zimasonyeza kuchepa kwa ubongo wa Aβ mu chitsanzo chathu, ndipo tikuyembekezera kudziwa momwe kusintha kumeneku kumakhudzira khalidwe ndi chidziwitso," anatero Dr. Yuede. 

Kafukufuku wamtsogolo wa Dr. Cirrito ndi Dr. Yuede adzafufuza zotsatira za HT-ALZ pa kukumbukira, nkhawa, ndi ntchito yaikulu mu APP / PS1 +/- mbewa chitsanzo pambuyo pa dosing yosatha ndi HT-ALZ.