The amygdala -kapangidwe kaubongo komwe kamakulitsidwa mwa ana azaka ziwiri omwe adapezeka ndi autism spectrum disorder (ASD) - imayamba kukula mwachangu pakati pa miyezi 6 ndi 12 yakubadwa, akuwonetsa kafukufuku wothandizidwa ndi National Institutes of Health. Amygdala imagwira ntchito pokonza malingaliro, monga kutanthauzira mawonekedwe a nkhope kapena kuchita mantha akakumana ndi zoopsa. Zomwe zapezazi zikuwonetsa kuti chithandizo chochepetsera zizindikiro za ASD chikhoza kukhala ndi mwayi waukulu wopambana ngati ayamba m'chaka choyamba cha moyo, amygdala asanayambe kukula kwake.
Phunziroli linaphatikizapo makanda 408, 270 omwe anali ndi mwayi wochuluka wa ASD chifukwa anali ndi mchimwene wake wamkulu wa ASD, 109 omwe amakula makanda, ndi makanda 29 omwe ali ndi Fragile X syndrome, mtundu wobadwa nawo wa chitukuko ndi luntha. Ofufuzawo adachita ma scan a MRI a ana azaka 6, 12 ndi 24 zakubadwa. Iwo adapeza kuti makanda 58 omwe adayamba kukhala ndi ASD anali ndi amygdala yowoneka bwino pamiyezi 6, koma amygdala yokulirapo pa miyezi 12 ndi miyezi 24. Kuphatikiza apo, kufulumira kwa kuchuluka kwa amygdala, kukulirakulira kwa zizindikiro za ASD pa miyezi 24. Makanda omwe ali ndi Fragile X syndrome anali ndi njira yosiyana ya kukula kwa ubongo. Iwo analibe kusiyana kwa kukula kwa amygdala koma kukulitsa kwa ubongo wina, caudate, zomwe zimagwirizanitsidwa ndi kuwonjezereka kwa makhalidwe obwerezabwereza.
Gulu lofufuza, lomwe ndi gawo la network ya NIH Autism Centers of Excellence Infant Brain Imaging Study network, idatsogozedwa ndi Mark Shen, Ph.D., wa University of North Carolina ku Chapel Hill ndi Infant Brain Imaging Study. Kafukufukuyu akupezeka mu American Journal of Psychiatry. Ndalamazo zidaperekedwa ndi Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) wa NIH, National Institute of Environmental Health Sciences ndi National Institute of Mental Health.
Olembawo adanenanso kuti kuvutikira kusanthula chidziwitso chakumva ali wakhanda kumatha kutsindika amygdala, zomwe zimapangitsa kuti azikula.
ASD ndi vuto lachitukuko lovuta lomwe limakhudza momwe munthu amachitira, amachitira zinthu ndi ena, amalankhulana komanso amaphunzira.
ZOMWE MUNGACHITE PA NKHANIYI:
- The findings indicate that therapies to reduce the symptoms of ASD might have the greatest chance of success if they begin in the first year of life, before the amygdala begins its accelerated growth.
- They found that the 58 infants who went on to develop ASD had a normal-sized amygdala at 6 months, but an enlarged amygdala at 12 months and 24 months.
- The study included 408 infants, 270 of whom were at higher likelihood of ASD because they had an older sibling with ASD, 109 typically developing infants, and 29 infants with Fragile X syndrome, an inherited form of developmental and intellectual disability.
