AMPEL BioSolutions lero yalengeza kutsogola kwamankhwala olondola komanso okhazikika omwe atha kusintha momwe madotolo amachitira ndi matenda otupa akhungu, monga Lupus, Psoriasis, Atopic Dermatitis ndi Scleroderma. Zawululidwa mu nyuzipepala yowunikiridwa ndi anzawo Science Advances, pepalali limafotokoza za njira yophunzirira yamakina ya AMPEL kuti athe kuwonetsa zochitika za matenda kuchokera ku chidziwitso cha jini chomwe chimatengedwa kuchokera ku biopsies yapakhungu ya odwala. Kuyesa kwa labu, lingaliro lazaka zingapo zapitazi, tsopano ndi lokonzeka kuti ligwiritsidwe ntchito. Cholinga choyambirira cha AMPEL chinali Lupus, koma kuyesako kumatha kugwiritsidwa ntchito pa matenda ambiri a autoimmune kapena otupa omwe amakhudza anthu opitilira 35 miliyoni aku America.
Njira yatsopano yophunzirira makina ya AMPEL, yomwe tsopano yakonzeka kupangidwa ngati chigamulo chothandizira mayeso a biomarker, ingakhudze kwambiri chisamaliro chaumoyo polola madokotala kuzindikira chomwe chimayambitsa zizindikiro za matenda ndikusankha chithandizo choyenera molondola. Njira ya AMPEL imakhala yozindikira mokwanira kuti izindikire kusintha kwa khungu losakhudzidwa kotero kuti kuchitapo kanthu mwachangu kuteteze kuphulika kwadongosolo ndi kuwonongeka kwa khungu komwe kumawonekera m'mabala. Kugwiritsa ntchito njira yophunzirira makina ya AMPEL kungathandizenso makampani opanga mankhwala pakupanga mankhwala ndi kuyesa kwachipatala.
Odwala omwe ali ndi matenda akhungu nthawi zambiri amavutika ndi matenda osayembekezereka omwe amakhudza zochitika za tsiku ndi tsiku monga ntchito ndi moyo wabanja. Popeza kuti zizindikiro zosayembekezereka nthawi zambiri zimabweretsa maulendo opita ku Malo Odzidzimutsa, kuthekera kodziwiratu matenda omwe akuwonjezereka komanso kukhudzidwa mwadongosolo ndi zochitika zapakhungu zachizoloŵezi zimakhala ndi zofunikira pazaumoyo komanso zachuma.
Kuphatikizidwa ndi zida za AMPEL zowunikira ma dataset azachipatala akulu kwambiri komanso ovuta ("Big Data"), pulogalamu yophunzirira makina ya AMPEL ndi gawo lofunikira pakukhazikitsa mayeso anthawi zonse akhungu kuti azitha kuyang'anira zochitika za matenda ndikupereka chithandizo chamankhwala motengera jini ya wodwala. mawu. Izi zidzasintha momwe madokotala amachitira matenda aakulu a khungu pogwiritsa ntchito chidziwitso chomwe chinasonkhanitsidwa ndi mayeso a labu ndikuwunikiridwa ndi makina ophunzirira kuti azindikire, kuwonetsa zolakwika zenizeni za maselo ndi kuchiza matenda a khungu asanayambe kuwonongeka, kupulumutsa odwala ku ululu ndi zovuta za matenda omwe mwinamwake zimakhudza kwambiri miyoyo yawo.
Makampani opanga mankhwala amayesa mankhwala m'mayesero achipatala ndikukumana ndi vuto lolembetsa odwala omwe ali ndi mwayi woyankha mankhwala omwe akuyesedwa. Kulembetsa odwala "olakwika" kungapangitse kuti mayesero alephereke, zomwe nthawi zambiri zimalepheretsa chitukuko cha mankhwala kuti chivomerezedwe ndi FDA chomwe chingakhale chopindulitsa pagulu la odwala onse. Mayeso a khungu a AMPEL athandiza makampani opanga mankhwala kuzindikira odwala omwe angayankhire chithandizo chamankhwala enaake, motero zimathandizira kukonza zotuluka m'mayesero azachipatala.
Dr. Peter Lipsky, Chief Medical Officer and Co-Founder, AMPEL BioSolutions: “Panopa palibenso ntchito ina imene ingathe kuneneratu zochitika za matenda ndi kupereka chithandizo choyenera, ndipo tikulimbikitsidwa kwambiri ndi zimene zalembedwa m’buku la Science Advances. Kwa odwala omwe ali ndi matenda akhungu, njira zochiritsira sizingachitike posachedwa. Kutsatira chitukuko cha malingaliro athu ophunzirira makina, tsopano titha kupita patsogolo pogwira ntchito limodzi ndi anzathu kupanga mayeso akhungu awa omwe angasinthe momwe madokotala angathandizire odwala omwe ali ndi matenda akhungu omwe amatha kuthana ndi vuto lawo popereka chithandizo chabwino komanso cholondola malinga ndi munthu payekha. deta ya odwala m'malo mwa njira wamba."
Dr. Amrie Grammer, Chief Scientific Officer ndi Co-Founder, AMPEL BioSolutions: "" Gulu lathu lapanga chida chomwe chingasinthe momwe odwala omwe ali ndi khungu amachitira. Monga kampani yolondola yamankhwala, AMPEL ikusintha mawonekedwe a chithandizo mu matenda a autoimmune ndi kutupa. Ndife onyadira kuti tikugwira ntchitoyi ku Virginia ndipo tipitiliza kulembera anthu talente ndikukulitsa bizinesi yathu kuno. ”
Dr. Wright Caughman, Pulofesa, dipatimenti ya Dermatology, Emory School of Medicine, ndi Exec VP for Health Affairs (Emeritus), Emory University: "Mayeso a AMPEL a khungu la biopsy adzapereka chida chatsopano kwambiri chodziwira ndi kuyang'anira autoimmune ndi yotupa matenda a khungu. AMPEL ikupereka ntchitoyi pa msonkhano wa Society for Investigative Dermatology kumapeto kwa mwezi uno. Mayeso a AMPEL a genomic akatsimikiziridwa ndi CLIA, madokotala azitha kuzindikira mwachangu mankhwala abwino kwambiri kwa wodwala aliyense ndikuwongolera matenda awo mwachangu komanso motetezeka.
ZOMWE MUNGACHITE PA NKHANIYI:
- This will transform the way doctors treat chronic skin diseases by using the information gathered by the lab test and analyzed by machine learning to diagnose, characterize the precise molecular abnormalities and treat skin diseases before damage begins, saving patients from pain and inconvenience of a disease that otherwise drastically affects their lives.
- Paired with AMPEL’s pipeline of tools to analyze very large and complex clinical datasets (“Big Data”), AMPEL’s machine learning program is a significant step towards implementing a routine skin test for monitoring disease activity and providing decision support for treatment based on a patient’s gene expression.
- Following the development of our machine learning concept, we can now move forward in working with our partners to develop this skin test that could transform the way doctors can help patients with chronic skin disease manage their condition by offering better and more precise treatments based on individual patient data rather than a general approach.
