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Chithandizo cha Khansa ya Pancreatic: Kulimbikitsa Zotsatira Zakupulumuka

Written by mkonzi

Cantargia AB lero yalengeza zotsatira zaposachedwa za CANFOUR phase I/IIa yofufuza za nadunolimab mu mzere woyamba wa chithandizo cha khansa ya pancreatic (PDAC) kuphatikiza ndi chemotherapy. Zomwe zasinthidwa kuchokera kwa odwala 33 oyambira omwe ali oyenera kuwunika momwe zimagwirira ntchito zikupitiliza kuwonetsa zotsatira zamphamvu kuposa zomwe zimayembekezeredwa kuchokera ku chemotherapy kokha.

Kupulumuka kwapakati ndi miyezi 12.7, kupulumuka kwapakatikati kwa chitetezo chamthupi (iPFS) ndi miyezi 7.2, ndipo kupulumuka kwa chaka chimodzi ndi 1%. Panthawi yowunika, odwala 55 anali akadali ndi moyo ndipo odwala awiri anali kulandira chithandizo. Miyezo yachitetezo ndi kuyankha ndi yofanana ndi zosintha zam'mbuyomu kuyambira Meyi 12.

Interleukin-1 receptor accessory protein (IL1RAP) -binding antibody nadunolimab ndi pulogalamu yotsogolera ku Cantargia ndipo amafufuzidwa m'mayesero angapo azachipatala omwe amawunika mitundu yosiyanasiyana yamankhwala ophatikizika amitundu yosiyanasiyana ya khansa, pomwe PDAC ndi yomwe idaphunziridwa kwambiri. Mpaka pano, odwala oposa 70 a PDAC adalandira chithandizo cha nadunolimab pamodzi ndi gemcitabine ndi nab-paclitaxel mu gawo la I/IIa lophunzira zachipatala CANFOUR. Zosintha zomwe zanenedwa lero zachokera pagulu loyamba la odwala 33 omwe adawunikidwa kuti ali ndi mphamvu.

Pakuwunika kwakanthawi kosinthidwa, ndi nthawi yayitali yotsatiridwa kuposa zomwe zidawerengedwa kale zomwe zimapangitsa kusanthula kolimba, kupulumuka kwapakatikati ndi miyezi 12.7 ndipo kupulumuka kwa chaka chimodzi ndi 1%. Median iPFS ndi miyezi 55 yokhala ndi iPFS ya miyezi 7.2 ya 6%. Poyerekeza, mbiri yakale pamzere woyamba wa chithandizo cha odwala PDAC omwe ali ndi gemcitabine ndi nab-paclitaxel akuwonetsa kupulumuka kwapakati kwa miyezi 56 ndi chiwopsezo cha 8.5 chaka cha 1%, ndi PFS yapakatikati ya miyezi 35 yokhala ndi PFS ya 5.5-mwezi wa 6% 44. Panthawi yowunika, odwala awiri anali kulandirabe chithandizo ndipo odwala 1 akadali ndi moyo. Chochititsa chidwi n'chakuti, odwala 12 (6%) mu mayesero adalandira chithandizo kwa nthawi yaitali kuposa chaka chimodzi.

Mbiri yachitetezo sichinasinthidwe kuchokera pazomwe zidachitika kale komanso kuchuluka kwa neutropenia ndi febrile neutropenia kukhala wamkulu kuposa momwe amayembekezeredwa kuchokera ku chemotherapy yokha. Makamaka, febrile neutropenia imawonedwa panthawi yoyamba ya chithandizo ndipo imatha kupewedwa ndi chithandizo cha prophylactic ndi granulocyte growth factor G-CSF. Chochititsa chidwi n'chakuti palibe milandu yoopsa (giredi 3 kapena apamwamba) ya neuropathy, zotsatira zodziwika bwino za gemcitabine ndi nab-paclitaxel, zomwe zawonedwa.

Kuphatikiza apo, odwala 40 owonjezera a PDAC amafufuzidwa pakuwonjezera kwa kuyesa kwa CANFOUR. Zotsatira zochokera ku gawo ili la mayesero zikuyembekezeka kuti zikhwime kuti ziwonetsedwe pa H1 2022. Cantargia pakali pano ikukonzekera mayesero osasinthika komanso omwe angakhale ofunika kwambiri mu mzere woyamba wa khansa ya pancreatic. Mapangidwe ndi nthawi yake zidzawululidwa pokhapokha zokambirana zokonzekera ndi akuluakulu oyang'anira zikatha.

WTM London 2022 zidzachitika kuyambira 7-9 Novembala 2022. Lowetsani tsopano!

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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