Waya News

Zatsopano Zatsopano pa Warm Antibody Autoimmune Hemolytic Anemia

Written by mkonzi

Rigel Pharmaceuticals, Inc. lero adalengeza kufalitsidwa kwa deta mu American Journal of Hematology kuchokera ku lemba lotseguka, multicenter, Phase 2 chipatala kafukufuku wa fostamatinib akuluakulu omwe ali ndi kutentha kwa antibody autoimmune hemolytic anemia (wAIHA) omwe analephera chithandizo chimodzi choyambirira. Deta yofalitsidwa ikuwonetsa kuti fostamatinib, oral spleen tyrosine kinase (SYK) inhibitor, imachulukitsa mwachangu komanso mokhazikika milingo ya hemoglobin (Hgb), ndi mayankho omveka bwino a Hgb omwe amawonedwa pafupifupi theka la odwala, komanso mbiri yachitetezo ndi kulolera yogwirizana ndi zomwe zilipo. fostamatinib chitetezo database ya odwala pamapulogalamu angapo a matenda omwe adaphunziridwa. Bukuli, lotchedwa "Fostamatinib for the treatment of warm antibody autoimmune hemolytic anemia: Phase 2, multicenter, open-label study", likupezeka pa webusaiti ya magazini.

"Zotsatira zomwe tawona mu phunziro lathu la Gawo 2 la kutentha kwa magazi m'thupi la autoimmune hemolytic anemia zimalimbikitsa kuthekera kwa fostamatinib kuthandiza odwala omwe ali ndi vuto losowa kwambiri la magazi lomwe silinavomerezedwe ndi matenda omwe amawagwiritsa ntchito," atero a Raul Rodriguez, Purezidenti wa Rigel komanso wamkulu wamkulu. mkulu. "Ngati ivomerezedwa, fostamatinib ikhoza kukhala chithandizo choyamba kumsika kwa odwala omwe ali ndi wIHA mu 2023 ndipo chingakhale chizindikiro chachiwiri chovomerezeka cha fostamatinib."

Kafukufuku wa Phase 2 adayesa kuyankha kwa fostamatinib pa 150 mg BID (kawiri patsiku) mwa odwala akuluakulu omwe ali ndi wAIHA ndi hemolysis yogwira ntchito ndi Hgb yochepera 10 g / dL omwe adalephera kulandira chithandizo chimodzi choyambirira. Chomaliza chachikulu chinali Hgb chachikulu kuposa 10 g / dL ndi kuwonjezeka kwa ≥2 g / dL kuchokera pachiyambi ndi Sabata 24 popanda chithandizo chopulumutsa kapena kuikidwa magazi ofiira. Kafukufukuyu adawonetsa kuti 46% (11/24) ya odwala adakwanitsa kumapeto kwenikweni, ndi 1 woyankha mochedwa pa sabata 30 (onse oyankha 12 [50%]). Kuwonjezeka kwapakati pa Hgb kunadziwika pa Sabata 2 ndikupitilira pakapita nthawi. Zomwe zimachitika kwambiri (AEs) zinali kutsekula m'mimba (42%), kutopa (42%), kuthamanga kwa magazi (27%), chizungulire (27%), ndi kusowa tulo (23%). Ma AE anali otha kuyendetsedwa bwino komanso ogwirizana ndi nkhokwe ya chitetezo cha fostamatinib ya odwala opitilira 3,900 pa matenda angapo (rheumatoid nyamakazi, B-cell lymphoma, COVID-19, ndi immune thrombocytopenia (ITP)). Palibe zizindikiro zatsopano zachitetezo zomwe zapezeka.

Nkhani Zogwirizana

Ponena za wolemba

mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

Amamvera
Dziwani za
mlendo
0 Comments
Zolowetsa Pamakina
Onani ndemanga zonse
0
Mukufuna malingaliro anu, chonde yankhani.x
Gawani ku...