Kulembetsa Kumamaliza Kuyesa Kwatsopano mu Chifuwa Chosatha

Trevi Therapeutics, Inc. ndi kampani yazachipatala ya biopharmaceutical yomwe ikupanga kafukufuku wamankhwala Haduvio™ (nalbuphine ER). Lero, Trevi adalengeza kuti adamaliza kulembetsa mwachangu mayeso ake a Phase 2 Cough And NALbuphine (CANAL) pochiza chifuwa chachikulu cha odwala omwe ali ndi idiopathic pulmonary fibrosis (IPF) kutsatira zotsatira zomwe zidalengezedwa kale pakuwunika kwakanthawi (N=26). ). Mapeto amphamvu kwambiri adawonetsa kuchepa kwa 77.3% kwanthawi yayitali ya chifuwa chausana kuyambira koyambira ndi kugwiritsa ntchito Haduvio poyerekeza ndi kuchepa kwa 25.7% ndi placebo, kuwonetsa kuchepetsedwa kwa 52% kwa placebo mu geometric kumatanthauza kusintha kwanthawi yamasana. <0.0001).

Chifukwa chiyesocho chinakwaniritsa zofunikira pakuwunika kwakanthawi, masamba adadziwitsidwa kuti atha kulembetsa anthu oyenerera kale akuwunikidwa koma kuti palibenso ntchito ina yofunikira. Pafupifupi maphunziro 40 onse adalembetsa nawo kafukufukuyu. Kampani ikupitilizabe kuyembekezera kupereka lipoti lachitetezo komanso chitetezo pamitu yonse mgawo lachitatu la 2022.

IPF ndi matenda oopsa, omwe amathera moyo pomwe chifuwa ndi chimodzi mwa zizindikiro zodziwika kwambiri. Pali odwala 130,000 a IPF ku US komanso odwala opitilira 1 miliyoni omwe anali aku US, pomwe 85% mwa odwalawa amakhala ndi chifuwa chosatha. Palibe mankhwala ovomerezeka ochizira chifuwa chachikulu mu IPF, ndipo chifuwacho nthawi zambiri chimatsutsana ndi mankhwala oletsa antitussive. Odwala omwe ali ndi chifuwa chachikulu mu IPF amatha kutsokomola mpaka maulendo 520 patsiku, zomwe zimapangitsa kuti azikhala ndi nkhawa chifukwa zimabweretsa kupuma. Kutsokomola kapena nthawi zina kumabweretsa kutopa kwambiri, njala ya mpweya, kutaya mpweya wa okosijeni ndipo odwala ena amakumananso ndi vuto la mkodzo chifukwa cha chifuwa. Kukhudzidwa kwa chifuwa chosatha mu IPF kumapangitsanso kuchepa kwa masewera olimbitsa thupi, kuchepa kwa mtunda woyenda komanso kufunikira kogwiritsa ntchito mpweya wowonjezera. Kutsokomola kosatha mu IPF kumatha kukhala chizindikiro choyambirira cha matenda, kuzindikira odwala omwe ali pachiwopsezo chachikulu, kulosera nthawi yoti amwalire kapena kuwaika m'mapapo, komanso kumathandizira kuti njira za profibrotic zitheke komanso kuwonjezereka kwa matenda mu IPF.