Kulembetsa Koyamba kwa Ulcerative Colitis Wapakati-mpaka-Wamphamvu Kwambiri

Adiso Therapeutics, Inc. lero yalengeza kuti yatsiriza kulembetsa gulu lake loyamba la odwala mu Phase 1b yofufuza zachipatala yowunika ADS051 (BT051), njira yapakamwa, yoletsa m'matumbo, yaing'ono ya molekyulu yogulitsa neutrophil ndi kuyambitsa, ngati chithandizo chomwe chingatheke. kwa odwala omwe ali ndi matenda a ulcerative colitis (UC). Deta yakhungu idawonetsa kuti kulowetsedwa m'gululi kunali kotetezeka komanso kololedwa, kuthandizira kuyambitsa kulembetsa gulu lachiwiri la mlingo wapamwamba. 

Phase 1b iyi ndi yowerengeka, yakhungu iwiri, yoyendetsedwa ndi placebo, yokwera maulendo angapo kwa odwala omwe ali ndi UC yogwira ntchito kwambiri (NCT05084261). Zolinga zazikulu za phunziroli ndi chitetezo ndi kulolerana ndi cholinga chachiwiri cha pharmacokinetics, ndi zolinga zofufuza zochepetsera zolembera zokhudzana ndi neutrophil. Kafukufuku wa Gawo 1b uyu akutsata kafukufuku wa Mlingo umodzi wokwera wa Gawo 1amodzi mwa anthu odzipereka athanzi omwe adawonetsa kuti ADS051 ili ndi zoletsa m'matumbo popanda poizoni woletsa mlingo kapena zochitika zina zoyipa.

"Kuyang'ana ma neutrophils ndi njira yatsopano yochizira matenda a ulcerative colitis. Phunziro la Phase 1b ndi sitepe yotsatira pakuwunika momwe ADS051 ingaletsere mosamala komanso moyenera njira zazikulu zomwe zimadziwika kuti zimayambitsa kusamuka ndi kuyambitsa ma neutrophils mumatumbo momwe kutupa kwamphamvu mu UC kukupitilira. Mu phunziro ili tidzayang'ana zizindikiro za zochitika zachipatala ndi zizindikiro zoyamba za ntchito zachipatala zomwe zingatanthauze kuchepetsa kutupa kwa colonic ndikulimbikitsa machiritso a mucosal kwa odwala omwe ali ndi UC yolimbitsa thupi, "anatero Scott Megaffin, Chief Executive Officer, Adiso. "Kupitiliza kupititsa patsogolo chitukuko chachipatala cha ADS051 ndikofunikira chifukwa chakufunika kosakwanira kwa odwala omwe ali ndi UC omwe ali ndi njira zochepetsera m'matumbo zomwe zimangotengera kuzembetsa kwa neutrophil."