Gingko biloba amachepetsa kuwonongeka kwa mtima

Kugwira ntchito bwino kwa thupi la munthu kumafuna kuyenda kosalekeza kwa mphamvu monga adenosine triphosphate (ATP). Kuzungulira kwa tricarboxylic acid (TCA), njira yofunika kwambiri yopangira ATP mu mitochondria, ndi malo akuluakulu a metabolites ndipo amaonetsetsa kuti pakati pa ma cyclic intermediate, otchedwa 'metabolic flux.' Kuthamanga kumeneku kumakhulupirira kuti kumasokonezeka ndi matenda okhudzana ndi mtima monga myocardial ischemia (MI), momwe magazi amathamangira kumtima amachepetsedwa, minofu ya mtima, kapena cardiomyocytes, kulandira mpweya wokwanira. Kuchepetsa kaphatikizidwe ka ATP ndi kuchuluka kwa glucose kusweka, kapena "glycolysis," chizindikiro MI, koma kuwongolera kuzungulira kwa TCA kwa njira zamankhwala ndikovuta.       

Ginkgo biloba L. Tingafinye (GBE), yomwe ili ndi yogwira chigawo bilobalide, wakhala akugwiritsidwa ntchito ngati mankhwala otchuka azitsamba pochiza ischemic matenda a mtima, koma ndondomeko yake yeniyeni sichidziwika. Asayansi motsogozedwa ndi Prof. Jinlan Zhang wa ku China Institute of Materia Medica adavumbulutsa bwino sayansi yomwe ili ndi zotsatira za GBE za cardioprotective mu kafukufuku watsopano. "Malangizo a GBE okhudza kagayidwe kachakudya adakopa chidwi chathu chifukwa mtima umagwira ntchito mosalekeza ndipo umafunika mphamvu kuti ugwire ntchito yamagetsi," akutero Prof. Zhang.

Phunziroli, lomwe linasindikizidwa mu Journal of Pharmaceutical Analysis, limasonyeza momwe kusamutsidwa kwa carbon kuchokera ku glycolysis kupita ku TCA kuzungulira kumatsekedwa mu MI-affected cardiomyocytes. Asayansi adapeza kuti TCA flux idasokonekera bwino m'maselo awa, omwe adakonda kugwiritsa ntchito magwero ena a carbon m'malo mwa shuga kuti apereke mphamvu nthawi zonse. Ngakhale zili choncho, kutsekeka ndi kuwonongeka kwa ATP sikukanatha kupewedwa m'maselo ovulala. Ma Ischemic cardiomyocytes anali ndi ma enzymes ochulukirapo omwe adatembenuza ma kaboni kukhala metabolites, isanachitike komanso panthawi ya TCA, zomwe zikadapangitsa kuti ma metabolites adziunjike ndikusokoneza kagayidwe kachakudya, chifukwa sakanatha kulowa mopitilira muyeso.

Chochititsa chidwi n'chakuti pochiza maselo ovulala ndi GBE, olembawo adapeza kuti bilobalide ikhoza kuteteza mitochondria ndikusunga mbadwo wa ATP. Miyezo ya ma enzyme m'maselo omwe adalandira chithandizo idatsika ndikulepheretsa kudzikundikira kwa metabolite, kupititsa patsogolo kagayidwe kachakudya, ndikuchepetsa kupsinjika kwa ma cell amtima. Kusinthika kwa kagayidwe kachakudya m'maselo othandizidwa ndi GBE ndikosiyana ndi njira zomwe zidanenedwapo kale.

Kenako adayang'ana minofu ya myocardial ya makoswe omwe amathandizidwa ndi GBE, omwe adawonetsa zizindikiro zochepa za kuwonongeka kwa MI kuposa zitsanzo zamafuta osasinthidwa. Zomwe anapezazo zinali zogwirizana ndi maselo ovulala a ISO, kusonyeza kuti bilobalide imateteza minofu ya mtima.

Ngakhale kafukufuku wamankhwala a metabolic ku MI wapeza mphamvu posachedwapa, kupambana kudakali kutali. Zotsatira za chithandizo cha bilobalide zomwe zapezedwa mu kafukufukuyu sizimangopereka umboni wochulukirapo wa matenda a kagayidwe kachakudya a MI, komanso zimapereka chilimbikitso chamankhwala atsopano azitsamba.

"MI ndi chiopsezo chachikulu ku thanzi laumunthu padziko lonse lapansi ndipo kufotokozera matenda ake komanso mankhwala omwe angakhale nawo ndi ofunikira," akutero Prof. Zhang. "Zomwe tapeza zikuwoneka ngati zolimbikitsa, ndipo tikuyembekeza kuti tidzalimbikitsidwa ndi kafukufukuyu wokhudza kagayidwe kachakudya komanso maziko a chithandizo cha MI," akumaliza.