Mayesowa, opangidwa ndi mainjiniya azachipatala komanso akatswiri azachipatala ochokera ku Yunivesite ya Glasgow, amapereka zotsatira zofananira ndi mayeso akunyumba a COVID-19 pafupifupi mphindi 30.
Mu pepala latsopano lofalitsidwa lero mu nyuzipepala ya Nature Communications, gulu lofufuza likufotokoza momwe adapangira dongosolo. Imakhazikika pazomwe zidachitika m'mbuyomu pakuwunika mwachangu komanso ma virus ku Yunivesite, ndikupereka zotsatira zolondola 98%.
Matenda a chiwindi a C, kachilombo koyambitsa magazi omwe amawononga chiwindi, akuti akhudza anthu opitilira 70 miliyoni padziko lonse lapansi. Vuto la kachilomboka pachiwindi limachedwa, ndipo odwala sangazindikire kuti ali ndi kachilomboka mpaka atadwala kwambiri ndi zovuta zina monga cirrhosis kapena khansa.
Ngati matendawa apezeka asanakule kwambiri, amatha kuchiritsidwa ndi mankhwala otsika mtengo, omwe amapezeka mosavuta. Komabe, pafupifupi 80 peresenti ya anthu omwe ali ndi kachilomboka samadziwa za matendawa mpaka mavuto azachipatala achitika.
Zotsatira zake, anthu pafupifupi 400,000 padziko lonse lapansi amamwalira ndi matenda okhudzana ndi matenda a hepatitis C chaka chilichonse, ambiri mwa iwo akadatha kupulumutsidwa pozindikira komanso kulandira chithandizo.
Pakali pano, matenda a chiwindi C amapezeka mu labotale pogwiritsa ntchito njira ziwiri zomwe zimayesa magazi kukhalapo kwa ma antibodies ndi kuzindikira kachilombo ka RNA kapena ma antigen apakati.
Njirayi ingatenge nthawi yochuluka kuti ipereke zotsatira, ndikuwonjezera mwayi woti odwala ena omwe amayesa sabwereranso kuti adziwe zotsatira zake. Kupezeka koyezetsa kumachepanso m'mayiko opeza ndalama zochepa komanso zapakati, komwe anthu ambiri omwe ali ndi matenda a chiwindi C amakhala.
Ngakhale mayeso onyamula okhoza kupereka zotsatira mwachangu apangidwa m'zaka zaposachedwa, kulondola kwawo kumatha kuchepetsedwa, makamaka m'mitundu yosiyanasiyana ya anthu.
Dongosolo latsopano la timu yotsogozedwa ndi yunivesite ya Glasgow, komabe, ndiloyenera kugwiritsidwa ntchito padziko lonse lapansi. Zasinthidwa kuchokera ku njira yofananira yomwe adapanga kuti apereke matenda a malungo mwachangu, omwe adayesedwa ndi zotsatira zolimbikitsa ku Uganda.
Chipangizochi chimagwiritsa ntchito mapepala a origami opindika ngati mapepala kuti akonze zitsanzo za njira yotchedwa loop-mediated isothermal amplification, kapena LAMP. Njira yopindika mapepala imathandizira kuti chitsanzocho chisinthidwe ndikuperekedwa kuzipinda zitatu zazing'ono mu katiriji, zomwe makina a LAMP amatenthetsa ndikugwiritsa ntchito kuyesa zitsanzo za kukhalapo kwa hepatitis C RNA. Njirayi ndi yophweka mokwanira kuti ili ndi kuthekera, m'tsogolomu, kuperekedwa kumunda, kuchokera ku magazi omwe amatengedwa kuchokera kwa wodwala kudzera pa chala.
Njirayi imatenga pafupifupi mphindi 30. Zotsatira zimaperekedwa kudzera mumzere wosavuta kuwerengera wotsatira ngati mayeso oyembekezera kapena mayeso akunyumba a COVID-19, omwe amawonetsa magulu awiri pazotsatira zabwino ndi gulu limodzi lopanda pake.
Kuti ayese chitsanzo chawo, gululo linagwiritsa ntchito dongosololi kuti lifufuze zitsanzo za plasma za 100 zosadziwika kuchokera kwa odwala omwe ali ndi matenda aakulu a HCV ndi zitsanzo zina za 100 kuchokera kwa odwala omwe alibe HCV, omwe adakhala ngati gulu lolamulira. Zitsanzozi zidayesedwanso pogwiritsa ntchito mayeso amtundu wa Abbott RealTime hepatitis C kuti atsimikizire zotsatira za LAMP. Mayeso a LAMP adapereka zotsatira zomwe zinali zolondola 98%.
Gululi likufuna kugwiritsa ntchito dongosololi pamayesero am'munda ku sub-Saharan Africa chaka chamawa.
Pepala la gululi, lotchedwa 'Loop mediated isothermal amplification ngati chida champhamvu chodziwira msanga kachilombo ka hepatitis C', lasindikizidwa mu Nature Communications. Kafukufukuyu adathandizidwa ndi ndalama zochokera ku Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council ndi Wellcome Trust.
