Mayesero a Anthu Tsopano Ayamba Katemera Woteteza Matenda a Parkinson

Mwa katemera anayiwa, zotsatira zabwino kwambiri zinapezedwa ndi PV-1950, yomwe nthawi imodzi imayang'ana ma epitopes atatu a B cell a molekyulu ya pathological, kuwonetsa kuchepa kwakukulu kwa α-Synuclein ndi neurodegeneration mu ubongo wa katemera wa hα-Syn D mzere mbewa.            

Dr. Agadjanyan adati, "Kupanga katemera wotetezeka komanso wa immunogenic woloza mitundu yonse ya pathological α-Synuclein ndi cholinga cha IMM. Chofunika kwambiri, katemera wathu wogwira mtima kwambiri, PV-1950, adapanga kupanga ma anti-antibody amphamvu, kuchepetsa α-Synuclein ya pathological ndikuwongolera kupereŵera kwa magalimoto mumtundu wa mbewa wamatenda ndi wokonzeka kuyesedwa m'mayesero odzitetezera". Anapitiliza kuti, "PV-1950 ili ndi mitundu iwiri - imodzi yochokera ku DNA ndi imodzi yophatikizanso mapuloteni. Katemera wowonjezera wowonjezera wokhala ndi katemera wosiyanasiyana wa DNA ndi mapuloteni ndi njira ina komanso yodalirika yopezera mayankho ambiri a antibody. "

PD ndiye vuto lachiwiri lomwe lafala kwambiri muukalamba lomwe limakhudza magwiridwe antchito agalimoto ndi kuzindikira. Bungweli limayang'ana njira zopewera zopewera matenda a neurodegenerative monga PD, DLB, ndi AD. Katemera wa immunogenic akhoza kukhala njira yothandiza kwambiri yolepheretsa / kuletsa kuphatikizika kwa mapuloteni oopsa a α-Synuclein kuchokera pakuwunjikana ndikufalikira muubongo ndikuyimitsa kapena kuchedwetsa matendawa, idatero IMM.

"α-Synuclein ndi mapuloteni a neuronal omwe amagwirizanitsidwa ndi majini ndi neuropathologically ku α-synucleopathies zosiyanasiyana, kuphatikizapo Parkinson's disease (PD). Matenda akayamba, zimakhala zosatheka kuyimitsa, chifukwa chake kugwiritsa ntchito katemera wa MultiTEP wochokera ku IMM Nuravax akufuna kuyimitsa kapena kuchedwetsa matendawa mwa anthu omwe ali pachiwopsezo cha α-synucleopathies, "atero Roman Kniazev.