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Kuyesa Kwatsopano Kwachipatala kwa Matenda a Celiac

Written by mkonzi

Immunic, Inc. lero yalengeza za kuyambika kwa gulu la odwala mu gawo loyamba la kuyesa kwachipatala kwa IMU-1, chinthu chachitatu chachipatala cha kampaniyo, mwa odwala omwe ali ndi matenda a celiac.

IMU-856 ndi makina ang'onoang'ono omwe amapezeka pakamwa komanso mwadongosolo omwe amalunjika pa epigenetic regulator yosadziwika. Maphunziro a preclinical akuwonetsa kuti IMU-856 imatha kubwezeretsa zotchinga m'matumbo am'mimba komanso kukonzanso mapangidwe amatumbo ndikusunga chitetezo chokwanira. Kutengera chidziwitso chachipatala komanso choyambirira chomwe chilipo mpaka pano, kampaniyo ikukhulupirira kuti IMU-856 ikhoza kuyimira njira yatsopano komanso yothandiza kwambiri pochiza matenda am'mimba.

"Kuyambira kwa Gawo C la gawo ili lachidziwitso cha 1 kwa odwala matenda a celiac ndi chizindikiro chofunika kwambiri pa chitukuko cha IMU-856, ndipo tikuyembekeza kuti tidzatha kutsimikizira mphamvu zake zobwezeretsa matumbo osagwira ntchito popanda kusokoneza chitetezo cha mthupi," adatero Daniel Vitt, Ph.D., Chief Executive Officer ndi Purezidenti wa Immunic. "Chifukwa zimayimira kufunikira kosakwaniritsidwa komwe kumakhala ndi zizindikiro zodziwika bwino za matenda, timakhulupirira kuti matenda a celiac ndi chizindikiro choyambirira chachipatala kuti apereke umboni wa momwe IMU-856 imakhudzira zovuta komanso zosatha. Njira ya IMU-856 ikhoza kupereka njira yatsopano yochizira matenda ambiri oopsa komanso ofala kwambiri a m'mimba, ndipo timakhulupirira kuti angapereke chithandizo chamankhwala popanda zotsatirapo zoopsa zomwe zimagwirizanitsidwa ndi mankhwala ambiri a autoimmune. Kuphatikiza apo, tikuyembekeza kupereka zidziwitso zonse zachitetezo kuchokera pagawo limodzi lokwera komanso lokwera la mayeso achipatala omwe akuchitika mu gawo 1 la anthu athanzi, omwe akuyembekezeka kupezeka mgawo lachitatu la chaka chino. "

"Matenda a Celiac ndi matenda amtundu wanthawi zonse komanso oopsa amatumbo aang'ono omwe matenda ake amayamba chifukwa cha kuwonongeka kwa matumbo a gluten. Ngakhale kumamatira ku zakudya zopanda gluteni, odwala ambiri amakumana ndi matenda omwe nthawi zonse amatha kutsekula m'mimba, kupweteka kwa m'mimba, kuperewera kwa zakudya m'thupi komanso chiopsezo cha kuchepa kwa magazi m'thupi, kufooka kwa mafupa ndi khansa zina," adatero Andreas Muehler, MD, Chief Medical Officer. wa Immunic. "Pali kufunikira kwakukulu kwa chithandizo chamankhwala chogwira ntchito kwa odwala omwe ali ndi matenda a celiac, chifukwa njira yokhayo yochiritsira masiku ano ndi zakudya zopanda thanzi, zamoyo zonse, zomwe zimakhala zolemetsa, nthawi zambiri zimaletsa anthu, ndipo nthawi zonse zimalephera kuletsa matenda. . Poganizira za kuthekera kwa IMU-856 kubwezeretsa matumbo otchinga m'matumbo komanso kapangidwe ka matumbo, timakhulupirira kuti mankhwalawa ali ndi lonjezano lapadera pakuwongolera thanzi la m'mimba komanso kuthekera kwakugaya ndi kuyamwa bwino zakudya, potero amachepetsa zotsatira zanthawi yayitali ndikuwongolera thanzi lawo. moyo, zizindikiro za matenda ndi zovuta zomwe zingachitike m'tsogolomu. "

Magawo A ndi B a mayeso omwe akupitilira a gawo 1 akuwunika kuchuluka kwa IMU-856 pamiyeso yathanzi yamunthu. Gawo C lomwe layambika tsopano limapangidwa ngati kuyesa kwa masiku 28, osawona kawiri, koyendetsedwa ndi placebo komwe kumapangidwa kuti awone chitetezo ndi kulekerera kwa IMU-856 kwa odwala omwe ali ndi matenda a celiac panthawi yazakudya zopanda gluteni komanso zovuta za gluten. Pafupifupi odwala 42 akukonzekera kulembedwa m'magulu awiri otsatizana ndi IMU-856 yoperekedwa kamodzi patsiku kwa masiku 28. Zolinga zachiwiri zimaphatikizapo ma pharmacokinetics ndi zolembera za matenda, kuphatikiza zomwe zimayesa kapangidwe ka m'mimba komanso kutupa. Pafupifupi masamba 10 ku Australia ndi New Zealand akuyembekezeka kutenga nawo gawo mu Gawo C.

Kampaniyo imabwerezanso malangizo ake oyambirira kuti gawo lachiwiri la gawo lachiwiri la vidofludimus calcium (IMU 2) mu ulcerative colitis likuyembekezeka kupezeka mu June 838 komanso kuti chidziwitso choyambirira cha chipatala cha Gawo C la gawo loyamba lachipatala. kuyesa kwa IMU-2022 mu psoriasis kukuyembekezeka mu theka lachiwiri la 1.

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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