Mankhwala a COVID-19? Chifukwa chiyani mitengo yakufa ili yochepa ku Germany?

Palibe waku America yemwe ayenera kufa pa COVID-19, dotolo waku US waku Houston, Texas akuti. Dongosolo lake lamankhwala limathandizidwa ndi maphunziro aku Swiss omwe akupitilira ndikufalitsidwa ndi a  Kafukufuku Waku Switzerland. Kupambanaku kumatha kulembedwa pamlingo wochepa wakufa ku Germany.

Izi ndi zoona zenizeni, koma Swiss Policy Research ndi "Institute" yokhala ndi mikangano yambiri. Swiss Policy Research kapena Swiss Propaganda Research ndi tsamba la zilankhulo zambiri lomwe linakhazikitsidwa mu 2016, lomwe limadzitcha "gulu lodziyimira pawokha lopanda phindu lomwe likufufuza zabodza zapadziko lonse lapansi ku Switzerland ndi media zapadziko lonse lapansi"

Pa Epulo 20 eTurboNews radalengeza za nkhawa Wolemba Pulofesa waku Swiss Vogt, Katswiri wa Opaleshoni ya Mitsempha ya Mitsempha ya Mtima komanso ya thoracic yemwe anayesa kuwonetsa zolephera pakuwunika kachilomboka. Kafukufuku wake adasindikizidwa ndi bungwe lomwelo.

Germany yachita bwino ndi COVID-19 poyerekeza ndi maiko ena ambiri mderali, koma chodabwitsa ndi chiwerengero chochepa cha anthu omwe amafa. United States ili ndi anthu ambiri omwe anamwalira ka 5, Belgium pafupifupi kasanu ndi katatu, ndipo UK nthawi 8. Boma la US ku New York linali ndi anthu ochulukirapo 7 kuyerekeza ndi kuchuluka kwa anthu. Kuyerekeza uku kumatengera kuchuluka kwa anthu 16 miliyoni, kotero titha kufananizidwa.

Kodi nchifukwa ninji chiŵerengero cha imfa ku Germany ndichotsika kwambiri poyerekeza ndi ena?  eTurboNews adalankhula ndi katswiri wazachipatala ku Germany yemwe akuchita nawo chithandizo cha Coronavirus. Sadafune kutchulidwa dzina koma adati pali chifukwa chake. Zosungidwa ngati chinsinsi chamkati ndondomeko ya chithandizo ku Federal Republic of Germany imawoneka yosiyana kwambiri ndi madera ena.

Matenda 211,060, milandu 395 yatsopano lero, 9226 yafa, kuphatikiza ena awiri lero. Izi ndi zomwe zikuchitika ku Germany kwa COVID-19. Ajeremani 2,518 mwa 1 miliyoni anali ndi kachilomboka, ndipo 110 mwa miliyoni adamwalira.

Izi ndi zomvetsa chisoni, koma poyerekeza ndi Belgium yoyandikana nayo, anthu 849 mwa miliyoni adamwalira ndi 5,930 omwe ali ndi kachilombo. UK ikuwerengera kuti anthu 680 afa mwa miliyoni imodzi pomwe 4,475 ali ndi kachilombo pa miliyoni.

United States pano ikuwerengera miliyoni miliyoni pamilandu 14,344 pomwe 475 afa.

Ndondomeko yachipatala ya Germany yosasindikizidwa inatsatiridwanso ndi Dr. Stella, dokotala wamkulu wa chisamaliro ku Houston, Texas yemwe anapita kusukulu ku Nigeria. Adanena pagulu kuti "Palibe waku America yemwe ayenera kufa" Anawonjezera kuti: "Pali mankhwala a COVID-19." eTurboNews wawona vidiyo ndi mawu ake. Idachotsedwa ndi Facebook ndi YouTube chifukwa cha "kufalitsa zambiri zomwe zikutsutsana ndi malangizo a WHO."

Kafukufuku wa Immunological and serological akuwonetsa kuti anthu ambiri sakhala ndi zisonyezo kapena zizindikiro zochepa chabe akakhala ndi kachilombo ka corona, pomwe anthu ena amatha kukhala ndi matenda odziwika bwino kapena ovuta.

Kutengera ndi umboni wasayansi womwe ulipo komanso zomwe zachitika posachedwa, a SPR Collaboration imalimbikitsa kuti madotolo ndi aboma aziganizira zotsatirazi zachipatala cha Covid-19. chithandizo choyambirira za anthu omwe ali pachiwopsezo chachikulu kapena omwe ali pachiwopsezo chachikulu (onani maumboni pansipa).

Kutengera ndi ma protocol awa komanso ofanana kwambiri, madokotala aku US adanenanso Kutsika kwa 84% m'zipatala, a Kutsika kwa 50% pa chiwerengero cha imfa pakati pa odwala omwe agonekedwa kale m'chipatala (ngati adalandira chithandizo mwamsanga), komanso kusintha kwa odwala nthawi zambiri pasanathe maola.

Izi zidasindikizidwa mu Swiss Policy Research. Ndikofunika kuti odwala alangizidwe kukaonana ndi dokotala asanagwiritse ntchito ndondomeko yotereyi.

Chithandizo cha protocol

1. Zinc (75mg mpaka 100mg patsiku)
2. Hydroxychloroquine (400mg patsiku)
3. Quercetin (500mg mpaka 1000mg patsiku)
4. Azithromycin (mpaka 500mg patsiku)
5. Heparin (nthawi zambiri mlingo)

Chigawo choyambirira ndi nthaka, yomwe imalepheretsa ntchito ya RNA polymerase ya coronaviruses motero imaletsa kuchulukitsa kwa ma virus (onani maumboni pansipa). Hydroxychloroquine ndi Quercetin kuthandizira kuyamwa kwa zinc kwa ma cell. Azithromycin amaletsa mabakiteriya superinfections. Heparin imalepheretsa thrombosis yokhudzana ndi matenda ndi embolism mwa odwala omwe ali pachiwopsezo.

ZindikiraniQuercetin angagwiritsidwe ntchito kuwonjezera kapena m'malo mwa HCQ. Zotsutsana za HCQ (mwachitsanzo, favism kapena vuto la mtima) ndi azithromycin ziyenera kuwonedwa.

Zolemba zowonjezera

The chithandizo choyambirira kwa odwala zizindikiro zoyamba kuonekera ngakhale popanda kuyezetsa PCR ndikofunikira kuti matendawa asapitirire. Zinc, HCQ ndi quercetin zitha kugwiritsidwanso ntchito mwatsatanetsatane kwa anthu omwe ali pachiwopsezo chachikulu kapena omwe ali pachiwopsezo chachikulu (monga azachipatala).

Mosiyana ndi izi, kupatula odwala omwe ali pachiwopsezo chachikulu kunyumba komanso osalandira chithandizo msanga mpaka atayamba kukhala ndi vuto lalikulu la kupuma, monga momwe zimachitikira nthawi yotseka, kungakhale kovulaza.

Zotsatira zoyipa kapena zoyipa zomwe zili ndi hydroxychloroquine m'maphunziro ena zidakhazikitsidwa kuchedwa kugwiritsa ntchito (odwala odwala kwambiri), mopitirira muyeso (mpaka 2400 mg patsiku), ma data osinthidwa (zonyoza za Surgisphere), kapena kunyalanyazidwa kutsutsana (mwachitsanzo, favism kapena matenda a mtima).

Kuchiza koyambirira kutengera ndondomeko yomwe ili pamwambayi kumapangidwira pewani kuchipatala. Ngati kuchipatala kumakhala kofunikira, madokotala odziwa ICU amalangiza kupewa mpweya wabwino (intubation) ngati kuli kotheka komanso kugwiritsa ntchito oxygen therapy (HFNC) m'malo mwake.

Ndizomveka kuti ndondomeko yamankhwala yomwe ili pamwambapa, yomwe ndi yosavuta, otetezedwa ndi zotsika mtengo, zimatha kupereka mankhwala ovuta kwambiri, katemera, ndi njira zina zambiri zachikale.

Background

Mfundo yakuti HCQ ndiyothandiza polimbana ndi matenda a SARS coronaviruses inali kale atakhazikitsidwa mu 2005 pa nthawi ya mliri wa SARS-1. Zinc imalepheretsa kubwereza kwa RNA kwa coronaviruses zinapezeka mu 2010 ndi Ralph Baric, mmodzi wa akatswiri padziko lonse SARS virologists. HCQ imathandizira kutengeka kwa ma cell a zinc zinapezeka mu 2014 pankhani ya kafukufuku wa khansa. Kuti flavonoid quercetin amathandizanso ma kutengera zinki anali anapezanso mu 2014.

Zothandizira

General

• EVMS Critical Care Covid-19 Management Protocol (Paul Marik, MD, June 2020)

nthaka

1. phunziro: Zotsatira za mchere wa Zinc pa Respiratory Syncytial Virus Replication (Suara & Crowe, AAC, 2004)
2. phunziro: Zinc Imalepheretsa Coronavirus ndi Arterivirus RNA Polymerase Ntchito In Vitro ndi Zinc Ionophores Zimalepheretsa Kubwereza Kwa Ma virus Awa mu Chikhalidwe Cha Ma cell (Velthuis et al, PLOS Path, 2010)
3. phunziro: Zinc kwa chimfine (Ndemanga Yadongosolo ya Cochrane, 2013)
4. phunziroHydroxychloroquine ndi azithromycin kuphatikiza zinc vs hydroxychloroquine ndi azithromycin yokha: zotsatira za odwala omwe ali m'chipatala COVID-19 (Carlucci et al., MedRxiv, Meyi 2020)
5. Review: Kodi zowonjezera za zinc zimakulitsa mphamvu zachipatala za chloroquine/hydroxychloroquine kuti apambane pankhondo yamasiku ano yolimbana ndi COVID-19? (Derwand & Scholz, MH, 2020)
6. Review: Zinc supplementation kuti apititse patsogolo chithandizo chamankhwala pakati pa ana omwe ali ndi matenda opuma (WHO, Technical Report, 2011)
7. nkhani: Kodi Zinc Lozenges Zingathandize ndi Matenda a Coronavirus? (University of McGill, Marichi 2020)

Hydroxychloroquine

1. Studies: Chidule cha maphunziro opitilira 50 apadziko lonse a HCQ (C19Study.com)
2. phunziro: Chloroquine ndi choletsa champhamvu cha SARS coronavirus matenda ndi kufalikira (Vincent et al., Virology Journal, 2005)
3. phunziroChloroquine Ndi Zinc IonophoreXue et al, PLOS One, 2014)
4. phunziro: Madokotala amapangira malangizo othandizira odwala coronavirus (Ndemanga yaku Korea Biomedical, February 2020)
   
5. phunziro: Kugwirizana kwa akatswiri pa chloroquine phosphate pochiza chibayo chatsopano cha coronavirus (Guangdong Health Commission, February 2020)
6. phunziro: Kuchita bwino kwachipatala kwa zotumphukira za Chloroquine mu COVID-19 Infection: Kuyerekeza meta-kuwunika pakati pa Big data ndi dziko lenileni (Miliyoni et al, NMNI, (Agalatiya 2020)
7. phunziro: Chithandizo cha Hydroxychloroquine, Azithromycin, ndi Combination mwa Odwala Ogonekedwa Mchipatala ndi COVID-19 (Arshad et al, Int. Journal of Infect. Matenda, Julayi 2020)
8. phunziro: Odwala a COVID-19 - Chithandizo Chachiwopsezo Choyambirira ndi Zinc Plus Low Mlingo wa Hydroxychloroquine ndi Azithromycin (Scholz et al., Preprints, Julayi 2020)
9. Pulogalamu: Malangizo pakugwiritsa ntchito HCQ ngati prophylaxis pa matenda a SARS-CoV-2 (Indian Council of Medical Research, Marichi 2020)
10. Review: White Paper pa Hydroxychloroquine (Dr. Simone Gold, AFD, Julayi 2020)
11. nkhani: Chinsinsi Chogonjetsera COVID-19 Lilipo Kale. Tiyenera Kuyamba Kuigwiritsa Ntchito. (Pulofesa Harvey A. Risch, Newsweek, Julayi 2020)
12. nkhaniKugwiritsa Ntchito Hydroxychloroquine ndi Mankhwala Ena Polimbana ndi Mliri (Yale School of Medicine)
13. nkhani: Wasayansi waku Morocco: Kupambana kwa Chloroquine ku Morocco Kuwulula Kulephera ku Europe (Morocco World News, June 2020) Zemmouri akukhulupirira kuti 78% ya kufa kwa coronavirus ku Europe zikanapewedwa ngati mayiko aku Europe akanatengera njira yaku Morocco ya chloroquine.
14. nkhani (IT): Covid: palibe odwala anga omwe adamwalira, ndipo 5% yokha ndiyo adagonekedwa mchipatala (Italia Oggi, June 2020) Dr. Cavanna adachiza omwe adakhudzidwa ndi kachilomboka pochitapo kanthu mwachangu komanso kunyumba.

Quercetin

1. phunziro: Mamolekyu ang'onoang'ono omwe amatsekereza kulowa kwa acute kupuma kwapamtima kwa coronavirus m'maselo omwe akulandira (Ling Yi et al., Journal of Virology, 2004)
2. phunziro: Zinc Ionophore Activity of Quercetin ndi Epigallocatechin-gallate: From Hepa 1-6 Cells to Liposome Model (Dabbagh et al., JAFC, 2014)
3. phunziroQuercetin ngati Antiviral Agent Imalepheretsa Kulowa kwa Virus Influenza A (Wu et al, Virus, 2016)
4. phunziroQuercetin ndi Vitamini C: Njira Yoyesera, Synergistic Therapy for Prevention and Treatment of SARS-CoV-2 Related Disease (Biancatelli et al, Front. ku Immun., Juni 2020)
5. Report: EVMS Critical Care Covid-19 Management Protocol (Paul Marik, MD, Juni 2020)

Heparin

1. Ndemanga: Heparin yosunthika mu COVID-19 (Thachil, JTH, Epulo 2020)
2. phunziro: Chithandizo cha Anticoagulant Chimalumikizidwa Ndi Kuchepa Kwa Imfa mu Matenda Owopsa a Coronavirus Odwala 2019 Odwala Coagulopathy (Tang et al, JTH, Meyi 2020)
3. phunziro: Zotsatira za Autopsy ndi Venous Thromboembolism mwa Odwala Omwe Ali ndi COVID-19 (Wichmann et al., Annals of Internal Medicine, Meyi 2020)
4. nkhani: Anticoagulation Guidance Emerging for Severe COVID-19 (Medpage Today)

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