Malaysia Airlines idawonetsa kubwerera kwawo ku Paris ndikuyambiranso ntchito yake yotsegulira ndege ya Charles de Gaulle (CDG). Ndege ya MH22 inanyamuka pa Kuala Lumpur International Airport (KLIA) Terminal 1 nthawi ya 11:45 PM nthawi zakomweko (MYT) pa 22 Marichi 2025, ikutera ku Paris nthawi ya 6:40 AM nthawi yakomweko (CET) pa 23 Marichi 2025. Ndege iyi ndi chizindikiro cha 68 cha Malaysia Airlines ngati gawo lofunikira kwambiri kupita ku Asia.

Maulendo apandege oyambilirawo adayankha mochititsa chidwi, chifukwa cha katundu wa MH22 ndi ndege yake yobwerera MH21 yomwe idafika 95 peresenti ndi 98 peresenti, motsatana, zomwe zikuwonetsa kufunikira koyenda pakati pa Malaysia ndi France. Kuyambira pa Marichi 22 mpaka 27, 2025, Malaysia Airlines izikhala ndi maulendo anayi sabata iliyonse pakati pa Kuala Lumpur ndi Paris, kukulirakulira tsiku lililonse kuyambira pa Marichi 29.