Mankhwala Atsopano a Antidiabetic okhala ndi Triple Combination Therapy

Daewoong Pharmaceutical adalengeza zotsatira zapamwamba za mayeso achipatala a gawo 3 la chithandizo chophatikiza katatu cha Enavogliflozin, mankhwala atsopano oletsa shuga omwe ali ndi makina a SGLT-2 inhibitor, okhala ndi Metformin ndi Gemigliptin. Enavogliflozin ndi SGLT-2 inhibitor ya matenda a shuga pakukula kwa Daewoong koyamba ku South Korea.               

Pulofesa Sungrae Kim wa pa chipatala cha Catholic University of Korea Bucheon St. Mary's Hospital monga wofufuza komanso ofufuza akuluakulu ochokera m'mabungwe 27 achita nawo gawo lachitatu la kuyesa kwachipatala kwa Enavogliflozin ngati mankhwala osakaniza katatu ndi Metformin ndi Gemigliptin. Kafukufukuyu adachitidwa ngati mayeso achipatala apakati, osasinthika, osawona, komanso owongolera mwachangu gawo lachitatu lomwe linali ndi odwala 3 omwe ali ndi matenda a shuga a 3.

Odwala omwe ali ndi matenda a shuga a 2, omwe adapatsidwa Metformin ndi Gemigliptin, adapatsidwa Enavogliflozin kapena Dapagliflozin kwa milungu 24, ndipo kusintha koyambirira kwa glycated hemoglobin (HbA1c) pakati pamagulu awiriwa adafanizidwa panthawi ya chithandizo. Zotsatira zake, odwala omwe adalandira Enavogliflozin adawonetsa kuchepa kwa HbA1c ndi 0.92% ndi 0.86% mwa omwe adalandira Dapagliflozin, kuwonetsa kutsika kwa Enavogliflozin poyerekeza ndi Dapagliflozin.

Chitetezo cha Enavogliflozin chinatsimikiziridwanso mwa odwala omwe ali ndi matenda a shuga omwe amafunikira chithandizo chosakanikirana cha Metformin ndi Gemigliptin, chifukwa panalibe zovuta zomwe zingachitike mwadzidzidzi kapena kuyanjana ndi mankhwala. Chitetezo cha Enavogliflozin chatsimikiziridwa kudzera m'mayesero atatu otsatizana azachipatala a monotherapy, kuphatikiza metformin, ndi kuphatikiza kwa metformin ndi Gemigliptin.

Pulofesa Kim adati, "Kuyesa kwachipatala kwa Enavogliflozin kuphatikizika katatu poyerekeza ndi Dapagliflozin pa odwala pafupifupi 270 aku Korea T2DM kwa milungu 24 kwatsimikizira chitetezo komanso kutsika kwa shuga m'magazi a Enavogliflozin." "Zikuyembekezeka kuti Enavogliflozin imakhala njira yabwinoko yochizira yomwe ikuwonetsa monotherapy komanso kuphatikiza mankhwala ophatikizika," adawonjezera.

Kutulutsa zotsatira zomveka kuchokera muyeso lachipatala la gawo 3 la mankhwala ophatikizira atatu a Enavogliflozin, Daewoong tsopano ndi gawo loyandikira kutulutsidwa kwa choletsa chatsopano cha SGLT-2 kwa nthawi yoyamba ku South Korea. Daewoong akukonzekera nthawi yomweyo kufunsira kuvomerezedwa kwamankhwala atsopanowo ndikuyambitsa osati Enavogliflozin yokha komanso Enavogliflozin/Metformin yophatikiza mankhwala osakhazikika pofika theka loyamba la 2023. Daewoong adatulutsa zotsatira zapamwamba za gawo 3 la mayeso azachipatala a Enavogliflozin monotherapy ndi Metformin. kuphatikiza mankhwala Januware.