Zatsopano Zatsopano pa Zotupa Zaubongo Za Ana

Kazia Therapeutics Limited yalengeza zatsopano zachipatala zomwe zikuwonetsa ntchito ya paxalisib mu mitundu iwiri ya khansa ya muubongo yaubwana yomwe imafuna chithandizo chamankhwala chosakwanira.       

Izi ndi mutu wankhani zitatu zomwe zidaperekedwa pa Msonkhano Wapachaka wa American Association for Cancer Research (AACR), womwe unachitikira ku New Orleans, LA, kuyambira Epulo 8 - 13, 2022.

Zolemba ziwiri za asayansi omwe amagwira ntchito mu labotale ya Wothandizira Pulofesa Jeffrey Rubens ku yunivesite ya Johns Hopkins ku Baltimore, MD, akufotokoza kugwiritsa ntchito paxalisib ngati chithandizo chamsana mu khansa yaubwana yaubwana yomwe imadziwika kuti atypical teratoid / rhabdoid tumors (AT/RT). Aka ndi koyamba kuti deta yofufuza paxalisib mu mtundu uwu wa khansa ya muubongo iwonetsedwe, ndipo imatsegula chidziwitso chatsopano chofunikira cha mankhwalawa.

Chidule chachitatu, chochokera ku gulu lina la asayansi ku yunivesite ya Johns Hopkins, motsogozedwa ndi Wothandizira Pulofesa Eric Raabe ndi Dr Katherine Barnett, adawonetsa umboni wa mgwirizano wamphamvu pakati pa paxalisib ndi gulu lina lamankhwala a khansa mu chitsanzo cha diffuse intrinsic pontine glioma (DIPG) . Paxalisib adawonetsa kale umboni wa zochitika mu matendawa, monga monotherapy komanso kuphatikiza ndi mitundu ingapo ya chithandizo cha khansa, ndipo deta yatsopano imatsimikiziranso kuthekera kwake mu matenda ovuta kwambiriwa.

Mfundo Zowunika

• AT/RT ndi khansa ya muubongo yosowa kwambiri yomwe imakhudza kwambiri makanda ndi ana aang'ono. Palibe mankhwala ovomerezeka a FDA a AT/RT ndipo njira zochiritsira zomwe zilipo ndizochepa kwambiri. Ocheperapo mmodzi mwa odwala asanu omwe amakhala ndi moyo zaka zopitirira ziwiri kuchokera ku matenda.

• Deta yochokera ku labotale ya Pulofesa Rubens ikuwonetsa kuti njira ya PI3K nthawi zambiri imagwira ntchito mu AT/RT, komanso kuti chithandizo cha paxalisib chokha chimagwira ntchito m'mitundu yoyambirira ya matendawa. Kuphatikiza apo, kuphatikiza ndi RG2822, HDAC inhibitor, kapena TAK580, inhibitor ya MAPK, ikuwoneka kuti ikulitsa kupulumuka poyerekeza ndi chithandizo chamankhwala amodzi.

• DIPG ndi khansa ya muubongo yomwe imapezeka mwa ana aang'ono ndi achinyamata. Palibe mankhwala ovomerezeka a FDA, ndipo nthawi zambiri amayembekezeka kukhala ndi moyo kuchokera pakuzindikira matenda pafupifupi miyezi khumi.

• Deta yam'mbuyomu kuchokera kumagulu angapo a ofufuza, makamaka ochokera ku gulu la Pulofesa Matt Dun ku Hunter Medical Research Institute, awonetsa kuti paxalisib imagwira ntchito kwambiri mu DIPG ndipo imaphatikizana molumikizana ndi mankhwala angapo a khansa.

• Deta yochokera kwa Drs Raabe ndi Barnett ndi ogwira nawo ntchito imazindikiritsa kuphatikiza kwatsopano kwamankhwala, ndi HDAC inhibitor RG2833, yomwe imasonyeza umboni wa mgwirizano wamphamvu mu chitsanzo choyambirira cha DIPG.

Mtsogoleri wamkulu wa Kazia, Dr James Garner, anawonjezera kuti, "Izi ndi deta yodalirika kwambiri, ndipo tikuthokoza gulu la Johns Hopkins chifukwa cha kafukufuku wofunikira komanso wolimbikitsawu. Paxalisib ndiyomwe idayesedwa kale mu gawo lachiwiri lachipatala ku DIPG ndikufalitsa ma gliomas apakati (NCT05009992) ndipo zatsopanozi zikuwonetsa kuti mankhwalawa angagwiritsidwe ntchito mokulirapo mu khansa yaubongo yaubwana. Tikuyembekezera kugwira ntchito ndi gulu la a Johns Hopkins, komanso ndi othandizana nawo komanso alangizi, kuti tifufuze mwayi umenewu. "