Zatsopano zokhudzana ndi kuchepetsa kuthamanga kwa magazi

Medtronic plc lero yalengeza za nthawi yayitali kuchokera kwa odwala 80 oyambirira mu mayesero a SPYRAL HTN-ON MED, omwe adaperekedwa lero ku American College of Cardiology's 71st Annual Scientific Session (ACC.22) kusweka mochedwa kumawonetsa magawo ofufuza zachipatala. Zambirizi zidasindikizidwanso nthawi imodzi mu The Lancet.

Odwala 80 oyambirira a mayesero a SPYRAL HTN-ON MED, deta inasonyeza kuti odwala omwe anapatsidwa mankhwala oletsa kuthamanga kwa magazi komanso kuthandizidwa ndi Medtronic Symplicity Spyral™ Renal Denervation (RDN) System adapitirizabe kusonyeza kuchepa kwamphamvu kwa magazi. kupyola zaka zitatu. Pa zaka zitatu:

• Kuchepetsa kwa 18.7 mmHg kwa odwala RDN motsutsana ndi 8.6 mmHg mu sham kwa maola 24 a systolic ambulatory blood pressure (ABPM)

• Kuchepetsa kwa 20.9 mmHg kwa odwala RDN motsutsana ndi 12.5 mmHg mu mkono wa sham wa office systolic blood pressure (OSBP)

"M'mayesero aposachedwa, kuchepetsa kutsika kwa magazi kosasunthika kwawonedwa kwa odwala omwe ali ndi matenda oopsa omwe amathandizidwa ndi Medtronic Symplicity Spyral RDN system," adatero Felix Mahfoud, MD, katswiri wamtima pachipatala cha Saarland University ku Homburg, Germany, ndi membala wa SPYRAL HTN. komiti yayikulu. "Kwa nthawi yoyamba, tsopano tili ndi deta yosadziwika bwino yomwe imasonyeza kuti mwa odwala omwe ali ndi matenda oopsa kwambiri omwe ali ndi mankhwala oletsa kuthamanga kwa magazi ndipo amathandizidwa ndi RDN - tikuwona kupitirira, kutsika kwa magazi kwa nthawi yaitali. Kutsika kwa kuthamanga kwa magazi kungakhale ndi zotsatira zabwino zachipatala kwa odwala, kuphatikizapo kuchepa kwa chiopsezo cha matenda a mtima. "

Mlanduwu udawonetsanso chitetezo chamchitidwe komanso nthawi yayitali ndi Symplicity Spyral renal denervation catheter, yokhala ndi zida zazikulu za zero kapena zochitika zachitetezo m'zaka zitatu.

"Ndi ON MED deta yosasinthika yomwe yaperekedwa ndi kufalitsidwa lero, Medtronic tsopano yasonyeza phindu la nthawi yaitali la kuchepa kwa aimpso kumbuyo kwa mankhwala oletsa kuthamanga kwa magazi, ndikuwonetseratu njira zotetezeka," adatero Jeffrey Popma, MD, mkulu. wachipatala wa bizinesi ya Coronary & Renal Denervation ndi bizinesi ya Structural Heart & Aortic, yomwe ili gawo la Cardiovascular Portfolio ku Medtronic. "Izi zikuwonetsa kufunikira kwa njira zina zochiritsira monga kulephera kwa aimpso."

Wovomerezedwa kuti agwiritse ntchito malonda m'maiko opitilira 60 padziko lonse lapansi, njira yochepetsera aimpso ya Symplicity Spyral imangogwiritsidwa ntchito pofufuza ku United States, Japan, ndi Canada.

SPYRAL HTN-ON MED ndi kuyesa kwapadziko lonse, kosasinthika, kosawerengeka, koyang'anira kutsika kwa magazi ndi chitetezo cha RDN ndi ma radiofrequency-based Medtronic Symplicity Spyral system mwa odwala omwe ali ndi matenda oopsa omwe amapatsidwa mankhwala amodzi kapena atatu oletsa kuthamanga kwa magazi. Deta yanthawi yayitali ya ON MED yomwe idaperekedwa ku ACC.22 idaphunzira gulu lomwelo la odwala monga kuwunika koyambirira kwa miyezi isanu ndi umodzi komwe kudasindikizidwa kale mu The Lancet mu 2018.

Medtronic imamaliza mwachisawawa mu gulu lonse la SPYRAL HTN-ON MED Trial

Medtronic idalengezanso kuti posachedwa idamaliza kusamutsa kwa gulu lonse la mayeso ake a SPYRAL HTN-ON MED ndikulembetsa kotseka. Gulu lathunthu lowunikira limayang'ana mpaka odwala 340 osasinthika. Medtronic akuyembekeza kuti kutsatiridwa kwa miyezi isanu ndi umodzi kwa gulu lonse kudzatha mu theka lachiwiri la kalendala ya 2022.

"Zomwe zafotokozedwa ku ACC zimatsimikizira chidaliro cha Medtronic mu RDN monga yankho kwa mamiliyoni a anthu omwe akudwala matenda a kuthamanga kwa magazi kosalamulirika. Deta yatsopanoyi idzakhala yofunika kwa akuluakulu oyang'anira, azachipatala ndi olipira pamene tikuyang'ana kubweretsa njira yatsopano yopangira chithandizo kwa odwala omwe ali ndi matenda oopsa kwambiri, "anatero Jason Weidman, wachiwiri kwa pulezidenti wamkulu ndi pulezidenti wa Coronary & Renal Denervation business unit, yomwe. ndi gawo la Cardiovascular Portfolio ku Medtronic. "Tikuyang'ana m'tsogolo, tikuyang'anabe zomwe zikuyembekezeredwa kwa miyezi isanu ndi umodzi ya gulu lonse la mayesero a ON MED mu theka lachiwiri la chaka cha kalendala."

Mayesero a SPYRAL HTN-ON MED ndi gawo la SPYRAL HTN Global Clinical Programme, kuwonjezera pa chitetezo ndi deta yothandiza kwa RDN. Pamodzi ndi zenizeni zenizeni zochokera ku Global Symplicity Registry, pamene zikuphatikizidwa ndi zochitika zamalonda, pakhala pali njira zoposa 20,000 zochitidwa ndi teknoloji ya Medtronic RDN. Pulogalamu yachipatala imathandizidwa ndi chidziwitso chokhwima komanso chozama cha odwala omwe amaphunziridwa pamaso komanso popanda mankhwala komanso odwala omwe ali ndi chiopsezo chachikulu cha mtima.