Mankhwala atsopano oyesera kuchiza tics kuchokera ku Tourette Syndrome

Malinga ndi kafukufuku watsopano woyambirira, ana ndi achinyamata omwe ali ndi matenda a Tourette omwe amathandizidwa ndi mankhwala oyesera otchedwa ecopipam atha kukhala ndi zotsatira zabwino pakuyesa kukhwima kwa tic miyezi itatu pambuyo pake. Kafukufuku yemwe watulutsidwa lero, Marichi 30, 2022, adzakambidwa pa Msonkhano Wapachaka wa American Academy of Neurology womwe ukuchitikira panokha ku Seattle, Epulo 74 mpaka 2, 7 ndipo pafupifupi, Epulo 2022 mpaka 24, 26. minyewa ya minyewa yomwe imadziwika ndi ma motor and tic tic, omwe ndi mayendedwe mobwerezabwereza ndi mawu omwe amachititsidwa ndi chikhumbo chosaletseka chowapanga.

"Zotsatira zathu ndizosangalatsa, chifukwa zimasonyeza kuti ecopipam imasonyeza lonjezo ngati chithandizo chochepetsera chiwerengero, mafupipafupi komanso kuopsa kwa achinyamata omwe ali ndi matenda a Tourette," anatero wolemba kafukufuku Donald L. Gilbert, MD, wa Cincinnati Children's Hospital Medical. Center ku Ohio, ndi Fellow of the American Academy of Neurology. "Izi ndi zoona makamaka chifukwa anthu ambiri omwe ali ndi matendawa omwe akumwa mankhwala omwe alipo panopa amakhalabe ndi zizindikiro zofooketsa kapena amawonda kapena mavuto ena."

Kafukufukuyu adayang'ana ana 149 ndi achinyamata azaka zapakati pa 17 ndi 74 omwe ali ndi matenda a Tourette. Adagawidwa m'magulu awiri: 75 adathandizidwa ndi ecopipam, XNUMX ndi placebo.

Ochita kafukufuku anayeza kuopsa kwa ma tic omwe adatenga nawo gawo pogwiritsa ntchito masikelo awiri omwe amafanana nawo kumayambiriro kwa phunzirolo komanso miyezi itatu pambuyo pake. Chiyeso choyamba chimayesa ma motor and vocal tics ndipo chimakhala ndi chiwerengero chachikulu cha 50. Chiyeso chachiwiri chimayang'ana zizindikiro zonse za tic ndi kuopsa kwa kuwonongeka kwa tic. Lili ndi chiwerengero chachikulu cha 100. Zotsatira zapamwamba pa mayesero aliwonse zimasonyeza zizindikiro zowopsya komanso zotsatira zoipa pa moyo wa tsiku ndi tsiku.

Pambuyo pa miyezi itatu, ofufuza adapeza kuti gulu lomwe limatenga ecopipam linali ndi ma tic ochepa komanso ocheperako ndipo anali kuchita bwino ponseponse malinga ndi mayeso onse awiri.

Pa avareji, omwe adatenga ecopipam adakweza mphamvu zawo zamagalimoto ndi mawu kuchokera pa 35 mpaka 24, kutsika ndi 30%. Izi zikufanizidwa ndi omwe amatenga placebo, omwe adakwera kuchokera pa 35 mpaka 28 nthawi yomweyo, kutsika ndi 19%.

Ofufuza atayang'ana zotsatira za mayeso achiwiri kuti awone momwe ecopipam imathandizira, adapeza kuti omwe amamwa mankhwalawa asintha kuchokera pa 68 mpaka 46, kuchepa kwa 32%, poyerekeza ndi omwe amatenga placebo, omwe adachita bwino. chiwerengero cha 66 mpaka 54, kuchepa kwa 20%.

Gilbert adanena kuti 34% mwa omwe adatenga ecopipam adakumana ndi zotsatira zoyipa monga mutu komanso kutopa, pomwe 21% mwa omwe adatenga placebo adakumananso.

"Kafukufuku wam'mbuyomu akuwonetsa mavuto a dopamine, neurotransmitter mu ubongo, angagwirizane ndi zizindikiro za Tourette syndrome, komanso kuti D1 dopamine receptors amagwira ntchito yofunika kwambiri," adatero Gilbert. "Dopamine receptors amapezeka m'katikati mwa mitsempha. Akalandira dopamine, amapanga zizindikiro za ntchito zosiyanasiyana zamaganizo ndi zakuthupi monga kuyenda. Ma receptor osiyanasiyana amathandizira kuwongolera ntchito zosiyanasiyana. Ngakhale ecopipam akadali mu gawo loyesera, ndi mankhwala oyamba kutsata cholandilira cha D1 m'malo mwa cholandilira cha D2, chomwe ndi chomwe chimayang'aniridwa ndi mankhwala omwe ali pamsika pano. Zotsatira zathu zikuwonetsa kuti ecopipam ikuyenera kuphunzira zambiri ngati njira yabwino yothandizira matenda a Tourette mwa achinyamata mtsogolo.

Kuchepetsa kwa phunziroli ndi kutalika kwa miyezi itatu. Gilbert adanenanso kuti ngakhale ndizokhazikika pamaphunziro amtunduwu, ndikofunikira kuphunzira ngati kusintha kwazizindikiro kupitilira nthawi yayitali.