Kafukufuku watsopano akuwonetsa kuti opitilira 1 miliyoni amafa chaka chilichonse ndi khansa ya chiwindi

Bungwe la World Health Organization likunena kuti kuyambira mu 2030, anthu oposa miliyoni imodzi adzafa chaka chilichonse ndi khansa ya chiwindi. Cold Spring Harbor Laboratory (CSHL) Pulofesa Adrian Krainer, wakale postdoc Wai Kit Ma, ndi Dillon Voss, Stony Brook University MD-Ph.D. wophunzira-mu-kukhala mu labu Krainer a, abwera ndi njira kusokoneza njira mphamvu kuti amalola khansa kukula ndi kufalikira. Posachedwapa adasindikiza ntchito yawo, yomwe inali mgwirizano ndi Ionis Pharmaceuticals, m'magazini ya Cancer Research.             

Asayansi a CSHL adagwiritsa ntchito antisense oligonucleotides (ASOs), omwe ndi ophatikizika a genetic code omwe amamangiriza ku RNA ndikusintha momwe maselo amapangira mapuloteni. Mamolekyuwa amasintha puloteni yomwe maselo a khansa ya chiwindi amagwiritsa ntchito kuchokera ku mtundu umodzi wa mapuloteni a pyruvate kinase (PKM2), omwe nthawi zambiri amawonetsedwa m'maselo a embryonic ndi khansa, kupita ku mtundu wina wa pyruvate kinase protein (PKM1), womwe umapangitsa kuti pakhale chotupa. Kusintha ntchito ya puloteniyi kumakhudza momwe maselo a khansa amagwiritsira ntchito zakudya, zomwe zingachepetse kukula kwawo. Monga Krainer akufotokozera, "Chosiyana ndi njira yathu ndikuti tikuchita zinthu ziwiri nthawi imodzi: tikukana PKM2 ndikuwonjezera PKM1. Ndipo tikuganiza kuti zonsezi ndi zofunika. ”

Ma ASO akulonjeza za khansa yamtundu wotere chifukwa atawabaya pansi pakhungu, thupi limawatumiza kuchiwindi. Khansa yachiwindi ingalephereke kukula ndi kufalikira ku ziwalo zina. Ofufuzawo adawona kuchepa kwakukulu pakukula kwa zotupa mumitundu iwiri ya mbewa zomwe adaphunzira. Kafukufukuyu akupitilira kafukufuku wam'mbuyomu mu labu ya Krainer momwe adasinthira PKM2 kukhala PKM1 m'maselo otukuka kuchokera ku khansa yaubongo yotchedwa glioblastoma.

Njirayi ilinso ndi phindu lina, popeza maselo athanzi a chiwindi sapanga RNA yomweyi yomwe ma ASO angayang'ane m'maselo a khansa ya chiwindi. Izi zimachepetsa kuthekera kwa zotsatira zilizonse zomwe sizingachitike. Voss akuti, "Kutha kupereka chithandizochi mwachindunji kuchiwindi, osakhudza maselo abwinobwino a chiwindi, kungapereke njira yothandiza komanso yotetezeka yochizira khansa ya chiwindi mtsogolomu."

Krainer, yemwe akugwira ntchito ndi antisense oligonucleotides m'matenda ena kuphatikiza cystic fibrosis ndi spinal muscular atrophy, akukonzekera kupitiliza kugwiritsa ntchito zida zochizirazi kufunafuna njira zochizira khansa ya chiwindi. Mwa mafunso ena, ofufuzawo akuyembekeza kufufuza ngati mamolekyu a RNA angathandize kukhala ndi metastases ya khansa ku chiwindi kuchokera ku ziwalo zina.