Katemera Watsopano Wotengera Shuga Akupangidwa Wa Melioidosis

Chiwopsezo cha Melioidosis ndi chenicheni. Bakiteriya amene amayambitsa matenda opatsiranawa amakhala osamva maantibayotiki, zomwe zimapangitsa kuzindikira ndi kuchiza kukhala kovuta kwambiri ndikupangitsa kuti anthu amafa mpaka 50%. Pulofesa Charles Gauthier wa bungwe la Institut national de la recherche scientifique (INRS) watha zaka khumi zapitazi akufufuza za matenda onyalanyazidwa a m’madera otentha. Popeza tsopano walandira ndalama zoposa $700,000 kuchokera ku Canadian Institutes of Health Research (CIHR), tsopano akuyamba kuyezetsa katemera wa katemera mogwirizana ndi mapulofesa Éric Déziel ndi Alain Lamarre.

Burkholderia pseudomallei imapezeka m'matope ndi dothi, makamaka m'mayiko a equatorial monga Australia, Thailand, India, ndi Brazil. Madzi osefukira kapena chilala chikachitika, amatha kuwononga tinthu tating'ono tomwe timatengedwa ndi mphepo. “Chifukwa cha kukwera kwa kutentha komanso chiwopsezo chowonjezereka cha masoka achilengedwe, kafukufuku akulosera kuwonjezereka kwa matenda ndi madera omwe ali pachiwopsezo. Tiyenera kukhala okonzeka,” akutero Pulofesa Gauthier.

Pazaka zisanu zikubwerazi, gulu lake lipanga katemera wa glycoconjugate. Choncho, shuga amene amapezeka pamwamba pa bakiteriyayo amakhala wogwirizana ndi mankhwala onyamula mapuloteni odziwika ndi maselo a T a m’thupi, omwe ndi “asilikali” amene amayambitsa kupanga maselo oteteza thupi ku matenda. Pulofesa Lamarre, yemwe ndi katswiri wa chitukuko cha katemera, ndi Pulofesa Déziel, katswiri wa tizilombo toyambitsa matenda a Burkholderia, adzachita maphunziro a katemera wa mbewa ndikufufuza momwe chitetezo cha mthupi chimayankhira.

Mashuga otsanzira

Gulu la asayansi liyesa mitundu ingapo ya katemera wophatikiza mitundu itatu ya shuga, kapena ma polysaccharides, owonetsedwa ndi bakiteriya. Shuga ndi wodalirika chifukwa amayang'aniridwa kale ndi ma antibodies. M'malo mowapatula mwachindunji ku bakiteriya, Pulofesa Gauthier amagwiritsa ntchito mashuga omwe adapangidwa m'ntchito yake yoyamba. Njirayi imapewa chiopsezo chogwira tizilombo toyambitsa matenda.

"Tatha kupanga ma polysaccharides omwe amatsanzira mabakiteriya, kuwonjezera pakudziwika ndi ma antibodies. Ndi ntchito yaupainiya,” iye anatero. Komabe, kaphatikizidwe kakapangidwe kake kayenera kukonzedwa bwino kuti muwonjezere zokolola zonse za shuga.

Monga membala wa maukonde a VALIDATE a University of Oxford pakupanga katemera wolimbana ndi tizilombo tomwe timanyalanyazidwa, Pulofesa Gauthier akhoza kudalira thandizo la asayansi ochokera padziko lonse lapansi. Mmodzi mwa ogwira nawo ntchito ndi wofufuza waku US Brad Borlee waku Colorado State University, yemwe amamupatsa mitundu yocheperako ya Burkholderia pseudomallei. Borlee amapanga shuga omwe adzagwiritsidwe ntchito ngati zowongolera za shuga "otsanzira" mu maphunziro a katemera. Gauthier akugwiranso ntchito ndi Pulofesa Siobhán McClean wa ku University College Dublin, wofufuza waku Ireland yemwe akufufuza za mapuloteni opangidwa ndi bakiteriya. Mapuloteniwa amalimbananso ndi chitetezo chamthupi ndipo amatha kugwiritsidwa ntchito limodzi ndi shuga kuti awonjezere mphamvu ya katemera.