Entrinsic Bioscience (EBS) yalengeza chida choyezera matumbo a m'mimba omwe angapangitse kuti pakhale mankhwala ochizira kudzimbidwa, kuphatikizapo Irritable Bowel Syndrome-Constipation (IBS-C). Wofufuza pa yunivesite ya Florida Dr. Sadasivan Vidyasagar, woyambitsa ndi wapampando wa bungwe la alangizi a sayansi la kampani, posachedwapa adagawana chida choyezera bwino peristalsis ndi kuyanjana kwa intraluminal pressure, kutsika kwa minofu, ndi kusintha kwa madzi amadzimadzi pamsonkhano wa Experimental Biology 2022 womwe unachitikira Philadelphia.
Peristalsis ndi njira yophatikizira yamatumbo am'mimba omwe amasuntha chakudya kudzera m'matumbo. Ngakhale adaphunziridwa mozama, kuwunika kwabwino kwa peristaltic propulsion sikumveka bwino chifukwa palibe chida chotsimikizika. Kupanda chida kuli ndi mwayi wopezeka ndi mankhwala osokoneza bongo pankhani ya kudzimbidwa, kuphatikiza IBS-C.
Vidyasagar ndi gulu lake, lomwe linaphatikizapo ofufuza a UF ndi Entrinsic Bioscience, adagwiritsa ntchito kuunikira kolowera, kujambula m'munda komanso kujambula mawu okakamiza kuti ayeze zochitika zam'mbuyo.
Stephen J Gatto, wapampando ndi CEO wa Entrinsic Bioscience, anayamikira Anusree Sasidharan ndi ena onse a gulu la Dr. Vidyasagar chifukwa cha kudzipereka kwawo poyendetsa njira zatsopano zowunika matumbo a m'mimba.
"Zowonetsera za gululi zikuwonetsa kuthekera kwathu kuyeza bwino matumbo a peristalsis ndikuyika njira zothandizira mtsogolo zomwe zitha kuthana ndi kudzimbidwa kosatha komwe kumachitika chifukwa cha opioid komanso njira yosagwirizana ndi PEG yokhudzana ndi kudzimbidwa kwakukulu ndi IBS-C. Matenda a m'matumbo a peristalsis ndi ofunika kwambiri pazochitika zambiri zachipatala, monga kudzimbidwa ndi matenda opweteka a m'mimba. "
"Kutha kuwongolera magawo a GI ndikuwunika zotsatira zake kungasinthe momwe timawonera nkhani za peristaltic pakubisa / kuyamwa," adatero Gatto. "Njira zokongolazi, tikuyembekeza kuti zipangitsa kuti njira zathu zochiritsira za RxAA zitheke mwachangu pochiza kudzimbidwa ndi IBS."
Vidyasagar adaperekanso chithunzi pazida zomwe labu yake adapanga kuti azitha kuyeza bwino matumbo a peristalsis komanso kuphatikizika kwa kuthamanga kwa intraluminal, kupindika kwa minofu, komanso kusintha kwamadzimadzi.
"Gulu lathu lapanga njira yatsopano yomvetsetsa ma peristalsis ndi magwiridwe antchito am'matumbo. Udindo wa SAA monga RxAAs ukuwonetsa lonjezano pamene tikutsegula njira za kudzimbidwa kosatha, IBS ndi matenda ena okhudzana ndi GI, "anatero Dr. William Denman, Chief Medical Advisor ku Entrinsic Bioscience. "Ntchitoyi idakali yoyambirira koma ikuyimira gawo lofunikira pakupanga njira zothetsera matenda angapo am'mimba."
Entrinsic Bioscience ndiwoyambitsa UF womwe uli ku UF Innovate | Fulumirani ku Sid Martin Biotech ku Alachua. Kampaniyo ikupanga mitundu yonse yachilengedwe, yopanda shuga ya hydration, thanzi lamatumbo ndi thanzi, ziwengo, ndi chisamaliro cha khungu.
ZOMWE MUNGACHITE PA NKHANIYI:
- Sadasivan Vidyasagar, founder and chairman of the company’s scientific advisory board, recently shared a tool to better measure peristalsis and the interactions of intraluminal pressure, muscle contraction, and changes in fluid volume at the Experimental Biology 2022 conference held in Philadelphia.
- Vidyasagar adaperekanso chithunzi pazida zomwe labu yake adapanga kuti azitha kuyeza bwino matumbo a peristalsis komanso kuphatikizika kwa kuthamanga kwa intraluminal, kupindika kwa minofu, komanso kusintha kwamadzimadzi.
- “The team’s presentation highlights our ability to better measure gut peristalsis and lays out the path for future treatment regimens that can address opioid-induced chronic constipation as well a non-PEG-based approach to acute constipation and IBS-C.
