Chithandizo Chatsopano Chikhoza Kuchedwetsa Kukula kwa Matenda a Alzheimer's

Moleac adalengeza kutulutsidwa kwa zotsatira za kafukufuku wa ATHENE, wofalitsidwa mu Journal of the American Medical Director Association (JAMDA).

Chithandizo chomwe chingachedwetse kudwala kwa AD chikafika pachimake, chimakhalabe chosowa chachipatala chomwe sichinakwaniritsidwe. NeuroAiD™II yawonetsa kukhala ndi zotsatira zosinthira pa amyloid precursor protein (APP) processing2 komanso kusintha kwa protein ya tau kukhala mawonekedwe achilendo a phosphorylated ndi ophatikiza3, komanso neuro-regenerative ndi neuro-restorative properties4. Zotsatira zopindulitsa za NeuroAiD™II pazidziwitso zosokoneza zawonetsedwa kale pakuvulala koopsa kwaubongo5.

Kafukufuku wa matenda a Alzheimer's Therapy with NEuoaid (ATHENE) ndi kafukufuku woyamba kuti awone zachitetezo ndi mphamvu ya NeuroAiD™II mwa odwala ocheperako mpaka ochepera a AD osakhazikika pamachiritso azizindikiro.

ATHENE anali kuyesa kwa mwezi wa 6 kosasinthika kwapawiri, koyendetsedwa ndi placebo komwe kumatsatiridwa ndi kutsegulira kwa mankhwala a NeuroAiD™II kwa miyezi ina ya 6. Maphunziro a 125 ochokera ku Singapore adaphatikizidwa mu mayesero, omwe adagwirizanitsidwa ndi Memory Aging and Cognition Center, National University Health System, National Neuroscience Institute, ndi St. Luke's Hospital, Singapore.

• NeuroAiD™II inasonyeza chitetezo cha nthawi yaitali ngati mankhwala owonjezera mu AD popanda kuwonjezeka kwa odwala omwe akukumana ndi zovuta zazikulu kapena zovuta.

• Kuyambika koyambirira kwa NeuroAiD™II kunapereka kusintha kwa chidziwitso kwa nthawi yaitali poyerekeza ndi placebo (gulu loyambira mochedwa) loyesedwa ndi ADAS-cog, yowerengera kwambiri pa miyezi 9, ndikuchepetsa kuchepa kwa nthawi.

Zotsatira za kafukufuku wa ATHENE zimathandizira kupindula kwa NeuroAiD™II ngati chithandizo chowonjezera chotetezeka ku chithandizo chamankhwala chokhazikika cha AD popeza kafukufukuyu sanapeze umboni wa kuwonjezeka kwakukulu kwa zochitika zovuta pakati pa MLC901 ndi placebo. Kuwunika kukuwonetsa kuthekera kwa MLC901 pochepetsa kuchulukira kwa AD komwe kumagwirizana ndi maphunziro azachipatala omwe adasindikizidwa kale, ndikupangitsa kukhala chithandizo chodalirika kwa odwala AD. Zotsatirazi zimafuna kutsimikiziridwa kwina mu maphunziro akuluakulu ndi aatali.                                                         

Mawu ochokera kwa Principal Investigator

"Matenda a Alzheimer's ndi omwe amayambitsa matenda a dementia, omwe ndi 60-80% ya milandu. Mpaka kuvomerezedwa kwaposachedwa kwa aducanumab ndi FDA, panalibe chithandizo chosinthira matenda cha matenda a Alzheimer's, ndipo chithandizo chazidziwitso chomwe chilipo pano chimafuna kuchedwetsa kwakanthawi kuipiraipira kwa zizindikiro za dementia ndikuwongolera moyo wa omwe ali ndi Alzheimer's ndi owasamalira. Chifukwa chake, pakufunika kupatsa odwala ndi owasamalira mwayi wopeza matenda ndi chithandizo chamakono.

Zotsatira zolonjezedwa za kafukufuku wa ATHENE ziyenera kumveka ngati gawo limodzi la kusintha kwa mapaipi akukula kwa matenda a Alzheimer's from symptomatic to the disease modifying therapies. Kafukufukuyu ndi mankhwala ena omwe angakhalepo ayenera kuunika mozama ndi mayesero azachipatala opangidwa bwino. "

Pulofesa Christopher Chen

Mtsogoleri, Memory Aging and Cognition Center, National University Health System ndi Pulofesa Wothandizira, Dipatimenti ya Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore.