Powulula kapangidwe ka puloteni yomwe mabakiteriya amagwiritsa ntchito potulutsa maantibayotiki, gulu lofufuza linapanga njira yochiritsira yoyambirira yomwe imawononga mpope ndikubwezeretsa mphamvu ya maantibayotiki.
Motsogozedwa ndi ofufuza ochokera ku Yunivesite ya New York, NYU Grossman School of Medicine, ndi Laura ndi Isaac Perlmutter Cancer Center ya NYU Langone, kafukufuku watsopanoyu adagwiritsa ntchito maikulosikopu apamwamba kuti "awone" kwa nthawi yoyamba kapangidwe ka NorA, mapuloteni omwe mtundu wa bakiteriya Staphylococcus. aureus amagwiritsa ntchito kupopera maantibayotiki omwe amagwiritsidwa ntchito kwambiri asanawaphe.
Mapampu a Efflux amaimira njira imodzi yomwe S. aureus yasinthira kukana kwa fluoroquinolones, gulu la maantibayotiki opitilira 60 ovomerezeka omwe amaphatikiza norfloxacin (Noroxin), levofloxacin (Levaquin), ndi ciprofloxacin (Cipro). Fluoroquinolones tsopano sagwira ntchito motsutsana ndi mitundu ina ya mabakiteriya osamva mankhwala, kuphatikizapo methicillin-resistance S. aureus (MRSA), chomwe chimayambitsa imfa pakati pa odwala omwe ali m'chipatala pamene matenda ayamba kwambiri, ofufuzawo akutero. Pazifukwa izi, mundawu udafuna kupanga ma efflux pump inhibitors, koma kuyesa koyambirira kwalephereka ndi zotsatirapo zake.
"M'malo moyesa kupeza mankhwala atsopano, tikuyembekeza kupanga maantibayotiki omwe amagwiritsidwa ntchito kwambiri m'zaka makumi angapo zapitazi, osagwira ntchito chifukwa cha kukana kwa mabakiteriya, ogwira ntchito kwambiri," akutero wolemba kafukufuku woyamba Doug Brawley, PhD. Anamaliza maphunziro ake a udokotala m'ma laboratories a olemba akuluakulu Nate Traaseth, PhD, pulofesa mu Dipatimenti ya Chemistry ku New York University, ndi Da-Neng Wang, PhD, pulofesa mu Dipatimenti ya Cell Biology ku NYU Grossman School of Medicine. .
ZOMWE MUNGACHITE PA NKHANIYI:
- He completed his doctoral thesis in the laboratories of senior authors Nate Traaseth, PhD, a professor in the Department of Chemistry at New York University, and Da-Neng Wang, PhD, a professor in the Department of Cell Biology at NYU Grossman School of Medicine.
- Powulula kapangidwe ka puloteni yomwe mabakiteriya amagwiritsa ntchito potulutsa maantibayotiki, gulu lofufuza linapanga njira yochiritsira yoyambirira yomwe imawononga mpope ndikubwezeretsa mphamvu ya maantibayotiki.
- “Instead of trying to find a new antibiotic, we hope to make the most widely used antibiotics over the last few decades, rendered ineffective by bacterial resistance, highly effective again,”.
