Kunenepa Kwambiri: Chithandizo Chatsopano Chatsopano

EOFlow Co., Ltd., omwe amapereka njira zoperekera mankhwala otha kuvala, yalengeza lero kuti kampani yake yonse yaku US, EOFlow Inc. yasaina pangano lokhazikitsa mgwirizano ku US ndi kampani yaku UK ya biotech ya Zihipp Limited, yomwe ndi spin. kuchokera ku Imperial College London.

Kukonzekera kwaumwini kwa ma analogue kumawapangitsa kuti azitha kubereka mosalekeza motero amalola kuti mlingo wa mankhwalawo ukhale wogwirizana ndi kagayidwe kake ka wodwala, kufulumizitsa kuwonda ndikupewa zotsatira zoyipa kuchokera pakumwa kwambiri. EOFlow ipereka ndalama zoyambira ndi nsanja yake yoperekera mankhwala EOPatch pomwe Zihipp imapereka ma analogi ake a peptide ndi chithandizo chachipatala cha SanPlena. EOFlow's founding CEO, Jesse J. Kim, adzalandira udindo monga woyambitsa CEO wa SanPlena pamene ena onse a gulu lalikulu adzazunguliridwa ndi akuluakulu ogwira ntchito ku Zihipp ndi EOFlow.

Zihipp ndi kampani yaku UK ya biotech yomwe idachokera ku Imperial College London ku 2012. Motsogozedwa ndi Prof. Sir Stephen R. Bloom wolemekezeka komanso gulu lofufuza padziko lonse lapansi, kampaniyo imapanga mahomoni a peptide kuti athane ndi kuchuluka kwa shuga komanso kunenepa kwambiri. Prof. Sir Stephen R. Bloom ndi mmodzi mwa akatswiri odziwa za kunenepa kwambiri padziko lonse lapansi ndipo kafukufuku wake wakhudza kwambiri mahomoni a m'matumbo omwe amawongolera chilakolako cha kudya ndi metabolism. Amadziwika bwino ngati munthu wodziwika bwino pakupanga msika wamankhwala okhudzana ndi matenda a shuga komanso kunenepa kwambiri. Pulofesa Sir Stephen Bloom ndi mkulu wa Drug Development, Department of Metabolism, Digestion & Reproduction ku Imperial College London komanso mkulu wa kafukufuku wa North West London Pathology ku Imperial College Healthcare NHS Trust, akutumikira zipatala zazikulu zisanu ndi chimodzi.

Zihipp yapanga anthu angapo atsopano a mankhwala a peptide omwe amakometsedwa chifukwa cha kunenepa kwambiri komanso chithandizo cha NASH (Non-Alcoholic Steatohepatitis) chofanana ndi chikhumbo chopondereza mahomoni monga oxyntomodulin ndi peptide YY omwe atsimikiziridwa kudzera m'mayesero azachipatala. Ma analogue awa adakonzedwa kuti azipereka mosalekeza mosalekeza kuti apewe zovuta zomwe zimachitika ndi jakisoni watsiku ndi tsiku kapena mlungu wa othandizira ofanana. SanPlena ikufuna kulimbikitsa zabwino za nsanja ya EOFlow yovala, ya digito kuti akwaniritse lonjezo la othandizirawa pakuwongolera kuwonda mwachangu komanso modabwitsa; mpaka 15% ya kulemera kwa munthu mkati mwa miyezi 2-3.

Malinga ndi World Health Organisation (WHO) ndi International Association for the Study of Obesity (IASO), mu 2016, akuluakulu oposa 1.9 biliyoni, azaka 18 kapena kuposerapo, anali onenepa kwambiri ndipo mwa awa, 650 miliyoni (34%) anali onenepa kwambiri. Thandizo lamakono la kunenepa kwambiri ndilochepa ndi mtengo, mwamsanga, mphamvu ndi kukhazikika. Mwachitsanzo, mankhwala omwe alipo kuti achepetse thupi amatha kutenga nthawi yopitilira chaka kuti achepetse thupi ndi 10-15% komanso nthawi zina zovuta zam'mimba. Pulatifomu yatsopano ya SanPlena imapereka chiwongolero chachikulu chosakwaniritsidwa cha njira zatsopano zochizira zochepetsera thupi.