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Zatsopano Zatsopano pa Solid Tumors Therapy

Written by mkonzi

Oncolytics Biotech® Inc. lero yalengeza kufalitsidwa kwa deta yosonyeza kuti pelareorep imagwirizana ndi khansa ya chimeric antigen receptor (CAR) T mu zotupa zolimba. Pepala, lotchedwa "Oncolytic virus-mediated exlated of the dual-Specific CAR T cells) limathandizira kulimbana ndi zotupa zolimba mu mbewa," linasindikizidwa mu Science Translational Medicine mogwirizana ndi ofufuza m'mabungwe angapo otchuka, kuphatikizapo Mayo Clinic ndi Duke University. Ulalo wa pepala ukhoza kupezeka podina apa.

"Kukhala ndi zotsatira izi kusindikizidwa m'magazini okhudzidwa kwambiri kumapereka chitsimikizo chofunikira chakunja cha kufunikira kwawo," anatero Thomas Heineman, MD, Ph.D., Chief Medical Officer wa Oncolytics Biotech Inc. "Ngakhale ma cell a CAR T apanga nthawi yayitali. amachiritsa matenda a hematologic malignancies1, the immunosuppressive tumor microenvironments (TMEs) ya khansa ya m'matumbo olimba mpaka pano yachepetsa mphamvu zawo pazizindikirozi. Pelareorep yasonyezedwa mobwerezabwereza kuti asinthe ma TMEs a immunosuppressive, ndipo m'buku lino pelareorep akuwonetsedwa kuti azitha kugwira ntchito kwa maselo a CAR T muzotupa zambiri za murine zolimba. Izi ndizopeza zamphamvu zomwe, ngati zitamasuliridwa ku chipatala, zitha kusintha kwambiri momwe odwala omwe ali ndi mitundu yosiyanasiyana ya khansa yofala kwambiri popereka chithandizo chamankhwala chokhazikika komanso chokhalitsa. Powonetsa kuthekera kopititsa patsogolo kupirira kwa T cell, kuchepetsa kuthawa kwa antigen, komanso kuthana ndi zovuta zotupa zotupa za TME, kuphatikiza kwa pelareorep kumayang'ana zotchinga zitatu zovuta kwambiri panjira yothandiza ya CAR T.

Andrew de Guttadauro, Purezidenti wa Oncolytics Biotech US ndi Global Head of Business Development, anawonjezera kuti, "Ngakhale kusintha kwa chithandizo cha khansa zina ndikuposa madola biliyoni pakugulitsa chaka chatha, chithandizo cha CAR T pakali pano chimangothandiza kagawo kakang'ono ka odwala omwe akudwala matenda a hematologic. matenda. Ndi zotsatira zaposachedwa, tili ndi umboni wamphamvu wotsimikizira kuti pelareorep imatha kumasula bwino kufunikira kwamankhwala a CAR T pokulitsa kuthekera kwawo pazamalonda pamsika wokulirapo kwambiri wa odwala khansa omwe akulimbana ndi zotupa zolimba. "

Maphunziro a preclinical omwe adasindikizidwa mu pepala adayesa kulimbikira ndi mphamvu ya maselo a CAR T odzaza ndi pelareorep ("CAR / Pela therapy") mumitundu yambiri yolimba ya murine yolimba. Zotsatira za kuphatikiza mankhwala a CAR / Pela ndi mlingo wotsatira wa mtsempha wa pelareorep ("pelareorep boost") adafufuzidwanso. Zofunikira zazikulu ndi ziganizo zochokera papepala zikuphatikizapo:

• Kulimbikira ndi ntchito yolimbana ndi khansa ya maselo a CAR T inayenda bwino kwambiri ikadzaza ndi pelareorep. Poyerekeza ndi chithandizo chokhachokha, chithandizo chamankhwala cha CAR/Pela chinapangitsa kuti pakhale phindu lochulukirapo pakhungu la murine ndi mitundu ya khansa ya muubongo.

• Chithandizo cha CAR / Pela chotsatiridwa ndi pelareorep boost chinapangitsa kuti pakhale mphamvu zowonjezera pakhungu la murine ndi zitsanzo za khansa ya ubongo ndi machiritso a chotupa mu> 80% ya mbewa zothandizidwa mu chitsanzo chilichonse.

• Kuyika ma cell a CAR T ndi pelareoep kunapangitsa kuti maselo a khansa azitha kuyang'ana bwino ndikuletsa kuthawa kwa antigen mu vivo popanga ma cell a CAR T okhala ndi mawonekedwe apawiri omwe amayang'ana ma antigen awo opangidwa ndi antigen ya T cell receptor. Zotsatirazi zikuwonetsa kuti chithandizo cha CAR / Pela chingapereke chithandizo chamankhwala chokhalitsa poyerekeza ndi chithandizo cha maselo a CAR T okha.

Dr. Matt Coffey, Purezidenti ndi Chief Executive Officer wa Oncolytics Biotech Inc. komanso wolemba nawo pepalali anati, "Zotsatira zosangalatsazi ndi chitsanzo chabwino kwambiri cha momwe tikulimbikitsira mgwirizano ndi atsogoleri ofunikira komanso mabungwe ofufuza kuti afutukule kuthekera kwa pelareorep. achire zotsatira. Izi zimatipangitsa kukhalabe olunjika pa pulogalamu yathu yotsogolera khansa ya m'mawere, yomwe yawonetsa momwe kuthekera kwa pelareorep kulimbikitsa kulowetsedwa kwa cell chotupa kumabweretsa ku synergy ndi ma checkpoint inhibitors kuchipatala. Zomwe zangotulutsidwa kumenezi zikuwonetsa maubwino a pelareorep a synergistic amapitilira ngakhale zoletsa zoletsa ndikuwonetsa mwayi wowonjezera kuchuluka kwa odwala omwe atha kutha. Pamene tikutsata mwayiwu kupita patsogolo, tikufuna kugwiritsa ntchito maubwenzi ndi ophunzira kapena ogwira nawo ntchito m'makampani kuti tipitilize kukwaniritsa zolinga zathu zachipatala komanso zamakampani. ”

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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