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Zotsatira Zoyesa Katemera wa COVID-19-Influenza Tsopano Zilipo

Written by mkonzi

Novavax, Inc. lero yalengeza zotsatira zoyambirira kuchokera ku mayeso achipatala a Phase 1/2 a COVID-Influenza Combination Vaccine (CIC). CIC imaphatikiza katemera wa Novavax 'COVID-19, NVX-CoV2373, ndi katemera wake wa quadrivalent fuluwenza. Kuyesa kwa CIC kunawonetsa kuti kupanga katemera wophatikiza ndi kotheka, kulolera bwino komanso chitetezo chamthupi.            

"Tikupitilizabe kuwunika momwe thanzi la anthu likuyendera ndipo tikukhulupirira kuti pangafunike kulimbikitsa mobwerezabwereza kuti athane ndi COVID-19 komanso chimfine chanyengo," atero a Gregory M. Glenn, MD, Purezidenti wa Research and Development, Novavax. "Timalimbikitsidwa ndi izi komanso njira yomwe ingathe kupitilira katemera wa COVID-19-fuluwenza komanso katemera wodziyimira pawokha wa chimfine ndi COVID-19."

Mbiri yachitetezo ndi kulekerera kwa katemera wophatikizayo inali yogwirizana ndi njira yodziyimira yokha ya NVX-CoV2373 ndi quadrivalent nanoparticle influenza vaccine formulations pakuyesa. Katemera wophatikiza anapezeka kuti amalekerera bwino. Zoyipa zazikulu zinali zosowa ndipo palibe zomwe zidayesedwa kuti zikugwirizana ndi katemera.

Kafukufukuyu adagwiritsa ntchito mfundo zofotokozera, kuyesa chitetezo ndi mayankho a immunological amitundu yosiyanasiyana ya katemera wa CIC. Njira yotengera Mayesero a Design of Experiments (DOE) idagwiritsidwa ntchito popanga kuyesako, ndikupangitsa kukonzanso kwamphamvu kwambiri pakusankha kwamankhwala a COVID-19 ndi ma antigen a chimfine kuti apititse patsogolo kuyerekeza ndi njira zachikhalidwe. Zotsatira zoyeserera zoyambilira zidapeza kuti mitundu yosiyanasiyana ya katemera wa CIC idapangitsa kuti chitetezo cha mthupi chitetezeke mwa omwe adatengapo gawo ngati chimfine chodziyimira chokha komanso katemera wa COVID-19 (wa H1N1, H3N2, B-Victoria HA ndi ma antigen a SARS-CoV-2 rS) . Zotsatira zotsatsira zidawonetsanso kuti kuphatikiza kophatikizana kumatha kuchepetsa kuchuluka kwa antigen mpaka 50% yonse, kukhathamiritsa kupanga ndi kutumiza.

Matemera onse opangidwa ndi mapuloteni omwe amagwiritsidwa ntchito poyeserera adapangidwa ndi saponin-based Matrix-M™ adjuvant kuti apititse patsogolo chitetezo chamthupi komanso kulimbikitsa ma antibodies ambiri. Izi zimathandizira kupititsa patsogolo kuyesa kotsimikizira kwa Gawo 2, komwe kukuyembekezeka kuyamba kumapeto kwa 2022.

WTM London 2022 zidzachitika kuyambira 7-9 Novembala 2022. Lowetsani tsopano!

Zambiri zamuyeso zinaperekedwa ku World Vaccine Congress (WVC) ku Washington, DC.

Influenza Program Update 

Ku WVC, Novavax adawunikiranso zomwe adapeza kuchokera muyeso la Gawo 3 la munthu yemwe adayimilira yekha chimfine, yemwe poyamba ankatchedwa NanoFlu, yomwe idakwaniritsa cholinga chake chachikulu cha immunogenicity. Zotsatirazi zidasindikizidwa kale mu The Lancet.

Chilolezo ku US

Ngakhale NVX-CoV2373 kapena ofuna katemera wa chimfine sanavomerezedwe kapena kuvomerezedwa kuti agwiritsidwe ntchito ku US ndi US Food and Drug Administration.

Zambiri Zofunikira Zachitetezo cha NVX-CoV2373

• NVX-CoV2373 ndi yotsutsana ndi anthu omwe ali ndi hypersensitivity ku chinthu chogwira ntchito, kapena kuzinthu zilizonse zothandizira.

• Zochitika za anaphylaxis zanenedwa popereka katemera wa COVID-19. Chithandizo choyenera chamankhwala ndi kuyang'anira ziyenera kupezeka ngati munthu ali ndi vuto la anaphylactic atalandira katemera. Kuyang'anitsitsa kwa mphindi zosachepera 15 kumalimbikitsidwa ndipo mlingo wachiwiri wa katemera sayenera kuperekedwa kwa omwe adakumana ndi anaphylaxis pa mlingo woyamba wa NVX-CoV2373.

• Zochita zokhudzana ndi nkhawa, kuphatikizapo vasovagal reactions (syncope), hyperventilation, kapena kupsinjika maganizo kungathe kuchitika mogwirizana ndi katemera monga kuyankha kwa psychogenic ku jekeseni ya singano. Ndikofunika kuti pakhale njira zodzitetezera kuti musavulale chifukwa cha kukomoka.

• Katemera ayenera kuyimitsidwa kwa anthu omwe akudwala chifuwa chachikulu kapena matenda oopsa. Kukhalapo kwa matenda ang'onoang'ono komanso/kapena kutentha thupi sikuyenera kuchedwetsa katemera.

• NVX-CoV2373 iyenera kuperekedwa mosamala kwa anthu omwe akulandira mankhwala oletsa magazi m'thupi kapena omwe ali ndi thrombocytopenia kapena matenda a coagulation (monga haemophilia) chifukwa magazi kapena mikwingwirima imatha kuchitika pambuyo pa kulowetsedwa mu mnofu mwa anthuwa.

• Mphamvu ya NVX-CoV2373 ikhoza kukhala yotsika mwa anthu omwe alibe chitetezo chamthupi.

• Kayendetsedwe ka NVX-CoV2373 pa mimba kuyenera kuganiziridwa pokhapokha ngati phindu lomwe lingakhalepo likuposa zoopsa zilizonse zomwe zingachitike kwa mayi ndi mwana wosabadwayo.

• Zotsatira za NVX-CoV2373 zitha kusokoneza kwakanthawi luso loyendetsa kapena kugwiritsa ntchito makina.

• Anthu sangatetezedwe mokwanira mpaka patatha masiku 7 atalandira mlingo wawo wachiwiri. Monga katemera onse, katemera wa NVX-CoV2373 sangathe kuteteza onse omwe amalandira katemera.

• Zomwe zimachitika nthawi zambiri pamaphunziro azachipatala zinali mutu, nseru kapena kusanza, myalgia, arthralgia, jekeseni wachifundo / ululu, kutopa, ndi malaise.

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mkonzi

Mkonzi wamkulu wa eTurboNew ndi Linda Hohnholz. Amakhala ku eTN HQ ku Honolulu, Hawaii.

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