Gawo Latsopano 1 Kuyesa Kwachipatala kwa Pediatric CNS Tumors

EpicentRx, Inc., kampani yopanga mankhwala ndi zida zamankhwala, mogwirizana ndi Texas Children's Cancer Center ku Houston, lero yalengeza za kuyambika kwa kafukufuku wa Phase 1 kuti awone chitetezo ndi phindu la molekyulu yake yaying'ono, RRx-001, kuphatikiza. irinotecan ndi temozolomide kwa odwala omwe ali ndi zotupa zobwerezabwereza kapena zopita patsogolo zolimba komanso zapakati zamanjenje. Kafukufukuyu, PIRATE (NCT04525014) adapangidwa ndi madokotala Holly Lindsay ndi Patricia Baxter ku Texas Children's Cancer Center ndipo adzalembetsa odwala 1 mpaka zaka 21 omwe ali ndi ubongo wobwerezabwereza kapena wopita patsogolo kapena zotupa za msana ndi zotupa zolimba, kupatulapo. lymphoma.        

Chiyambi cha kuyesa kwa PIRATE kudakhazikitsidwa pamayesero angapo am'mbuyomu omwe adatsimikizira kuti RRx-001 imawonjezera kuperekedwa kwa chemotherapy ndi kutenga zotupa. Chiyeso chachipatala cha Phase 1 chotchedwa G-FORCE (NCT02871843) ndi mayesero achipatala a Phase 1/2 otchedwa BRAINSTORM (NCT02215512) anasonyeza chitetezo cha RRx-001 komanso umboni wotheka wa chithandizo chamankhwala kwa odwala akuluakulu omwe ali ndi glioblastoma kapena GBM ndi ubongo. metastases, motero.

Maselo a khansa amapangidwa kuti aziyenda kumagulu osiyanasiyana m'thupi, komwe amakhazikitsa chotchinga choletsa kuperekedwa kwa mankhwala. Chimodzi mwamalingaliro a mayeserowa ndi chakuti RRx-001 "ikhoza "kuyambitsa" microenvironment ya chotupa, kupangitsa kuti chotupacho chikhale chogwira mtima kwambiri popereka irinotecan ndi temozolomide kotero kuti mphamvu yawo ikuwonjezeke ndikuwonjezera maselo a chitetezo cha mthupi monga macrophages kuti apite ku chiwonongeko. kudzera mu kutsutsa kwake kwa chizindikiro cha CD47 cha "musandidye". Lingaliro lina ndiloti RRx-001 idzateteza minofu yokhazikika, koma osati zotupa, kuchokera ku poizoni wa irinotecan ndi temozolomide.

"Ndife okondwa kuyambitsa phunziroli ndi RRx-001 ndikukhazikitsa udindo wake monga chithandizo chothandizira ana a CNS zotupa," anatero Tony R. Reid, MD, Ph.D., Chief Executive Officer wa EpicentRx. "Kuyesaku sikukanatheka popanda thandizo lachangu la Texas Children's Cancer Center. Monga momwe mayeso azachipatala m'matenda akuluakulu a CNS akuwonetsa kuti RRx-001 ikhoza kupereka phindu mwa ana, mgwirizano wathu ndi iwo ndi umboni wa kudzipereka kwa kampaniyi kutsatira zomwe zingawatsogolere. ”

"Pali zomveka zodziwikiratu komanso zachipatala zokhudzana ndi chitetezo ndi kuthekera kwa RRx-001 mu zotupa za CNS," adatero Dr. Holly Lindsay, MD, Pulofesa Wothandizira, Dipatimenti ya Pediatrics, Gawo la Hematology-Oncology, Baylor College of Medicine ndi kutsogolera. Wofufuza. "Kuchuluka kwa zotupa za CNS mwa ana kumakhala kovuta kwambiri kuchiza, ndipo tikuyembekeza kuti kafukufuku wa PIRATE apanga chidziwitso chofunikira kuti athandize zisankho zamtsogolo zachipatala."