Clarivate Plc, kampani yapadziko lonse lapansi yopereka zidziwitso ndi zidziwitso kuti ipititse patsogolo ukadaulo, lero yalengeza kutulutsidwa kwa lipoti lake lapachaka la Drugs to Watch™, kuzindikiritsa mankhwala omwe amalowa pamsika kapena kuyambitsa zisonyezo zazikulu mu 2022 zomwe zimanenedweratu kuti zikwaniritsa mawonekedwe a blockbuster 2026. Leveraging Clarivate data ndi zidziwitso, openda adapeza njira zisanu ndi ziwiri zoyeserera zomwe zatsala pang'ono kutha zomwe amalosera kuti zipereka malonda apachaka opitilira $ 1 biliyoni mkati mwa zaka zisanu. Mankhwalawa amatenga madera osiyanasiyana achirengedwe, kuyambira matenda monga Alzheimer's (AD), mphumu ndi mtundu wachiwiri wa matenda a shuga (T2DM), omwe amasautsa odwala mamiliyoni ambiri padziko lonse lapansi, mpaka matenda osowa, monga transthyretin amyloidosis (ATTR) , mwa ena.
Lipotilo limaperekanso kuwunika mozama kwa katemera wamkulu wa COVID-19 ndi njira zothandizira kuti muwonere, monga chithandizo cha ma cell ndi majini, CRISPR, kupezeka kwamankhwala motsogozedwa ndi luntha lochita kupanga komanso kuphunzira makina, RNA ndi njira zochizira khansa. . Kuphatikiza apo, lipotilo limawunika mankhwala a blockbuster ndi biologics omwe akukumana ndi mpikisano wamageneric chifukwa cha patent yaku US kutha mu 2022.
Kuyenda padziko lonse lapansi pazachipatala kumakhala kovuta, ndipo kupeza, kupanga ndi kugulitsa mankhwala opambana omwe amasintha miyoyo ya odwala kungakhale kovuta, makamaka masiku ano zomwe sizinachitikepo. Lipoti la Drugs to Watch likuwunikira chithandizo choyesera ndikulonjeza kwakukulu kuti akwaniritse zotulukapo zabwino za odwala komanso kuyesetsa kupeza ndalama m'badwo wotsatira wamankhwala amakono. Kupyolera mu njira zosinthira, kukonza bwino ndi kuchulukitsa anthu, makampani omwe ali ndi chithandizo chodalirikachi akupita patsogolo mwatsatanetsatane anthu ofuna chithandizo - akugwiritsa ntchito ukadaulo wozama m'malo awo ochizira komanso njira zanthawi yayitali zopezera njira zochiritsira pamikhalidwe imeneyi.
Pakati pa mankhwala atsopano ndi biologics omwe avomerezedwa kapena omwe atsala pang'ono kuchita, Clarivate wapeza mankhwala asanu ndi awiri omwe akukhulupirira kuti atha kukhala ndi vuto la blockbuster m'zaka zisanu zikubwerazi. Mankhwala Oyenera Kuwonera a 2022, akuphatikiza:
• Adagrasib, opangidwa ndi Mirati Therapeutics Inc ndi Zai Lab Limited - Chithandizo chomwe chakhala chikuyembekezeredwa kwa nthawi yayitali chingakhale njira yoyamba yothandizira odwala omwe ali ndi khansa ya colorectal (CRC) ndi kusintha kwa KRASG12C, omwe m'mbiri anali ndi njira zochepa zochizira. Mitundu yodziwika bwino ya KRAS oncoprotein nthawi zambiri imatengedwa ngati chandamale chamankhwala chomwe chimapangitsa kuti kulowetsedwa kwa KRAS inhibitor kwa odwala omwe ali ndi zotupa zolimba zosinthika kukhala zazikulu kwambiri.
• Faricimab, opangidwa ndi Roche ndi Chugai Pharmaceutical - Kwa odwala omwe ali ndi matenda a shuga a macular edema (DME) kapena kunyowa kwa zaka zokhudzana ndi zaka (AMD), faricimab imapereka njira yabwino kwambiri chifukwa idzaperekedwa mobwerezabwereza, pafupifupi, kuposa muyezo wa chisamaliro. . Monga antibody yoyamba ya bispecific yomwe idakhazikitsidwa mu ophthalmology, ilinso ndi kuthekera kochita bwino kwambiri kuposa momwe chisamaliro chamakono chimakhalira, ngakhale kuti deta mpaka pano ikuwonetsa kuti si yotsika poyerekeza ndi chisamaliro chamakono. Faricimab ndiye choletsa choyamba chapawiri cha VEGF/Ang-2 kuchiza DME ndi AMD yonyowa (komanso woyamba bispecific MAb m'dera la ophthalmology therapeutic).
• Lecanemab, opangidwa ndi Eisai Co Ltd ndi Biogen Inc, ndi donanemab, ochokera ku Eli Lilly and Company - Mumsika wosasamalidwa bwinowu, anti-Aβ MAbs lecanemab ndi donanemab ali okonzeka kutsatira chivomerezo cha U.S. FDA chofulumizitsa kuvomereza kwa ADUHELM kuchiza AD. Lecanemab ndi donanemab atha kupereka mbiri yodziwika bwino yazachipatala, zomwe zitha kulimbikitsidwa ndi zotsatira za gawo la 3 zomwe zikuyembekezeka kunenedwa kuyambira kumapeto kwa chaka cha 2022. Deta m'mayesero azachipatala ikuwonetsa kuti kuwonekera kokwanira kwa Mlingo wokwanira wamankhwala a anti-Aβ MAb kungakhale kothandiza pachipatala. koyambirira kwa AD.
• Tezepelumab, opangidwa ndi Amgen ndi AstraZeneca - Tezepelumab ndiwotheka kusintha masewera kwa odwala omwe alibe TH2 kapena TH2-otsika mphumu omwe mphumu yawo siyimayendetsedwa bwino ndi corticosteroids yopumira, muyezo wapanthawiyo wa chisamaliro. Ngati zivomerezedwa, zitha kukhala zamoyo zam'gulu loyamba kwa odwalawa. Tezepelumab ikhoza kukhala yoyamba ya biologic ya chifuwa chachikulu cha TH2-low komanso njira yothandizira odwala omwe ali ndi mphumu ya TH2-high omwe mankhwala omwe alipo sanapambane.
• Tirzepatide, yopangidwa ndi Eli Lilly ndi Company - Tirzepatide imapereka ziwonetsero zotsogola pakuchepetsa thupi komanso kuwongolera kwa glycemic control mwa odwala omwe akukula, omwe amatha kuchepetsa zovuta zamtundu wa 2 shuga mellitus (T2DM). Chithandizo chatsopano chomwe chitha kuthana ndi kuwonda komanso kuwongolera glycemic kuposa mankhwala omwe alipo kale chingakhale chopindulitsa kwambiri pazotsatira za odwala.
• Vutrisiran, opangidwa ndi Alnylam Pharmaceuticals - Kwa matenda omwe akupita patsogolo omwe ali ndi zosowa zambiri zosakwanira, mankhwalawa amabweretsa mphamvu, mbiri yabwino ya chitetezo, komanso kusintha kwa kaperekedwe komwe kungapindulitse moyo wa odwala. Odwalawa ali ndi njira zochepa zothandizira, makamaka kwa omwe ali ndi mtundu wa ATTR wamtchire. Sikuti mankhwalawa amalowa mumsika wocheperako, alinso ndi mlingo wosavuta kuposa mankhwala ena enieni a ATTR pamsika.
Mike Ward, Global Head of Life Sciences and Healthcare Thought Leadership, Clarivate: "Ngakhale makampani opanga mankhwala ndi biotech adayika ndalama zambiri zanzeru m'zaka ziwiri zapitazi kuthana ndi zovuta zomwe COVID-19 idakumana nazo, apitilizabe kugwiritsa ntchito matekinoloje atsopano kuti apange. mankhwala omwe angapereke zosankha kwa odwala omwe ali ndi matenda osachiritsika kapena osachiritsika omwe akuyimirabe vuto lalikulu lachipatala. Zosankha zowonera mankhwala zachaka chino, komanso ukadaulo wowonera, zikuwonetsa zatsopano zomwe zili pakatikati pa gawo lazamankhwala ndi biotech ndipo zithandizira zotsatira zabwino kwa odwala m'tsogolomu. "
Ngakhale mliri wa COVID wasokoneza msika wamankhwala m'njira zambiri, kuyambira kugwa kwapang'onopang'ono kwazinthu zazikulu 1 mpaka kuchedwa kwa mayeso achipatala2, makampani opanga mankhwala ndi biotech akupitilizabe kupititsa patsogolo zamankhwala. Opanga mankhwala akupita patsogolo kwambiri pakutsegula matekinoloje omwe angathandize kuti mankhwala azisankhidwa okha. Oyang'anira akuwonetsa kumasuka ku matekinoloje atsopano ndi njira zatsopano komanso kufunitsitsa kuthana ndi matenda omwe palibe chithandizo chawo. Komabe, ndizofunikira kuti makampani atsimikizire kufunika kwake kuti apambane kuvomerezedwa ndi msika ndikuwapangitsa kuti athe kupezeka kwa odwala.
