Kuzindikira bwino matenda a m'maganizo kungakhale kovuta, makamaka kwa ana aang'ono omwe sangathe kulemba mafunso kapena masikelo owerengera. Vutoli lakhala lovuta kwambiri makamaka kwa anthu ochepa omwe sanaphunzirepo. Kafukufuku wam'mbuyomu wa genomic adapeza zizindikiro zingapo zamatenda osiyanasiyana amisala, pomwe ena amakhala ngati njira zochizira. Njira zophunzirira mozama zagwiritsidwanso ntchito pozindikira matenda ovuta monga chidwi cha deficit hyperactivity disorder (ADHD). Komabe, zida izi sizinagwiritsidwe ntchito kawirikawiri mwa anthu ambiri aku Africa America.

Pakafukufuku wapadera, ofufuzawo adatulutsa zonse zotsata ma genome kuchokera ku zitsanzo zamagazi a odwala 4,179 a odwala aku Africa America, kuphatikiza odwala 1,384 omwe adapezeka ndi vuto limodzi laubongo , Autism spectrum disorder, luntha, kulankhula/chinenero, kuchedwa kwa chitukuko ndi oppositional defiant disorder (ODD). Cholinga cha nthawi yayitali ya ntchitoyi ndikuphunzira zambiri za kuopsa kwa matenda ena mwa anthu a ku America ku America komanso momwe angakhalire ndi thanzi labwino poyang'ana njira zothandizira anthu payekha.

"Kafukufuku wambiri amangoganizira za matenda amodzi okha, ndipo anthu ochepa sakhala akuimiridwa kwambiri m'maphunziro omwe alipo omwe amagwiritsa ntchito makina ophunzirira kuphunzira matenda a maganizo," anatero wolemba wamkulu Hakon Hakonarson, MD, PhD, Mtsogoleri wa Center for Applied Genomics ku CHOP. . "Tinkafuna kuyesa njira yophunzirira mozama iyi mwa anthu aku America aku America kuti tiwone ngati ingasiyanitse molondola odwala omwe ali ndi vuto la m'maganizo ndi kuwongolera bwino, komanso ngati tingatchule molondola mitundu yamavuto, makamaka odwala omwe ali ndi matenda angapo."

Ma algorithm ozama ophunzirira adayang'ana kulemedwa kwa mitundu yosiyanasiyana ya ma genomic m'magawo osungira komanso osalemba ma genome. Chitsanzocho chinasonyeza kulondola kwa 70% posiyanitsa odwala omwe ali ndi vuto la maganizo ndi gulu lolamulira. Njira yophunzirira mwakuya inali yothandizanso pakuzindikira odwala omwe ali ndi zovuta zingapo, ndipo chitsanzocho chimapereka mafananidwe enieni ozindikira pafupifupi 10% yamilandu.

Chitsanzocho chinazindikiritsanso bwino madera angapo a ma genomic omwe adalemeretsedwa kwambiri chifukwa cha matenda a maganizo, kutanthauza kuti amatha kutenga nawo mbali pa chitukuko cha matendawa. Njira zamoyo zomwe zimakhudzidwa ndizomwe zimakhudzidwa ndi mayankho a chitetezo chamthupi, kumanga kwa antigen ndi nucleic acid, njira yowonetsera chemokine, ndi ma guanine nucleotide-binding protein receptors. Komabe, ofufuzawo adapezanso kuti mitundu yosiyanasiyana m'magawo omwe sanakhazikitse mapuloteni amawoneka kuti akhudzidwa ndi zovutazi pafupipafupi, zomwe zikutanthauza kuti zitha kukhala ngati zolembera zina.

"Pozindikira mitundu yosiyanasiyana ya majini ndi njira zomwe zikugwirizana nazo, kafukufuku wamtsogolo wofuna kuzindikiritsa ntchito yawo angapereke chidziwitso cham'makina momwe matendawa amakulira," adatero Hakonarson.

Kafukufukuyu adathandizidwa ndi Institutional Development Funds kuchokera ku CHOP kupita ku Center for Applied Genomics ndi Chipatala cha Ana cha Philadelphia Endowed chair in Genomic Research.

ZOMWE MUNGACHITE PA NKHANIYI:

Pakafukufuku wapadera, ofufuzawo adatulutsa zonse zotsata ma genome kuchokera ku zitsanzo zamagazi a odwala 4,179 a odwala aku Africa America, kuphatikiza odwala 1,384 omwe adapezeka ndi vuto limodzi laubongo , Autism spectrum disorder, luntha, kulankhula/chinenero, kuchedwa kwa chitukuko ndi oppositional defiant disorder (ODD).
"Tinkafuna kuyesa njira yophunzirira mozama iyi mwa anthu aku America aku America kuti tiwone ngati ingasiyanitse molondola odwala omwe ali ndi vuto lamisala ndi njira zowongolera bwino, komanso ngati tingatchule molondola mitundu yamavuto, makamaka odwala omwe ali ndi matenda angapo.
Cholinga cha nthawi yayitali ya ntchitoyi ndikuphunzira zambiri za kuopsa kwa matenda ena mwa anthu a ku America ku America komanso momwe angakhalire ndi thanzi labwino poyang'ana njira zothandizira anthu payekha.