M'nkhani yaposachedwa yowunikira yomwe idasindikizidwa mu Coordination Chemistry Reviews, gulu la asayansi motsogozedwa ndi Pulofesa Chang Yeon Lee ndi Gajendra Gupta a ku Incheon National University, Korea, adakambirana za chisinthiko ndi kupita patsogolo kwaposachedwa pamagawo a BODIPY-based MOCs ndi MOFs, ndi yang'anani kwambiri pamagulu omwe angakhale nawo ngati mankhwala oletsa khansa komanso zida zofufuzira khansa. Nkhaniyi ikufotokoza ubwino ndi mgwirizano wa mankhwalawo ndi njira zina zamankhwala komanso ikufotokoza zopinga zazikulu zomwe zimagwiritsidwa ntchito pofala.
Ndiye, zinthu izi ndi chiyani ndipo zomwe zimapangitsa kuti zikhale zosakanikirana bwino? Ma MOC ndi ma MOF ndi ma zitsulo omwe amakhala ngati nsanja zosunthika momwe magwiridwe antchito atsopano amatha kuyambitsidwa mosavuta posintha. Onsewa amagwiritsidwa ntchito kwambiri mu biomedicine ndipo awonetsa kuthekera ngati anticancer agents ndi kusankha bwino. Komabe, BODIPY ikagwiritsidwa ntchito mu MOCs kapena MOFs, mawonekedwe azithunzi omwe amapangidwa amatha kusinthidwa bwino kuti akwaniritse zotsatira zosiyanasiyana.
Choyamba, ma complexes a BODIPY ndi abwino photosensitizing agents kwa photodynamic therapy, momwe mankhwala amalowetsedwa ndi kuwala kuti awononge maselo omwe akutsata. Akaphatikizidwa ndi ma MOC kapena ma MOF, mphamvu ya mankhwalawa monga mankhwala oletsa khansa amawonjezeka. Chachiwiri, ma complexes a BODIPY amakhudzidwa ndi acidity (pH) yapakati. Chifukwa zotupa zina zowopsa zimakhala ndi pH yotsika (acidic), mankhwalawa amatha kupangidwanso kuti athe kulunjika ma cell a khansa mkati mwa thupi pogwiritsa ntchito njirayi. Chomaliza, koma chocheperako, mawonekedwe a fulorosenti a ma MOC ndi ma MOF amatha kusinthidwa kuti malo awo mkati mwamaselo azitha kutsatiridwa mosavuta pogwiritsa ntchito njira zama microscopy za fluorescence. "Kukhala kosavuta kwa mankhwala opangidwa ndi BODIPY-based MOC / MOF mkati mwa maselo a khansa kumathandiza akatswiri a sayansi ya maselo ndi maselo kumvetsa momwe mamolekyuwa amachitira motsutsana ndi khansa," akufotokoza Prof. Lee.
Ngakhale pali zoletsa zina za BODIPY-based MOCs/MOFs, monga kaphatikizidwe ka nthawi komanso kumvetsetsa kwathu kosakwanira za kawopsedwe kake, mankhwalawa atha kukhala othandizira pankhondo yathu yolimbana ndi khansa. "Ma MOC ndi ma MOF opangidwa ndi BODIPY ali ndi zinthu zonse zofunika kuti munthu akhale woyenera kugwiritsa ntchito mankhwala osokoneza bongo," akumaliza Prof. Gupta. Onetsetsani kuti mukuyang'anitsitsa mamolekyu apamwambawa ndi zodabwitsa zomwe angabweretse kudziko la mankhwala a khansa ndi kafukufuku.
