Piritsi yolowetsedwa m'kamwa yokhala ndi cannabidiol (CBD) imachepetsa bwino ululu pambuyo pa opaleshoni yamapewa popanda nkhawa zachitetezo, kafukufuku watsopano apeza.
Motsogozedwa ndi ofufuza mu dipatimenti ya Opaleshoni Yamafupa ku NYU Langone Health, kafukufukuyu adapeza kuti piritsi la ORAVEXX limatha kupweteka bwino pambuyo pa opaleshoni yaying'ono yozungulira, ndipo silinabweretse zotsatira zoyipa zomwe nthawi zina zimagwirizanitsidwa ndi kugwiritsa ntchito CBD, monga nseru, nkhawa, ndi chiwindi kawopsedwe. Zotsatirazi zidaperekedwa ku Msonkhano Wapachaka wa American Academy of Orthopedic Surgeon's (AAOS) 2022 ku Chicago.
"Pakufunika mwachangu njira zina zothanirana ndi ululu, ndipo kafukufuku wathu akuwonetsa mawonekedwe awa a CBD ngati chida chodalirika pambuyo pokonzanso makapu a arthroscopic," akutero wofufuza wamkulu Michael J. Alaia, MD, FAAOS, pulofesa wothandizira ku dipatimenti ya zamankhwala. Opaleshoni Yamafupa. "Ikhoza kukhala njira yatsopano, yotsika mtengo yoperekera mpumulo wa ululu, komanso popanda zotsatira za mankhwala oletsa kutupa monga NSAIDs ndi chiopsezo choledzera chogwirizanitsidwa ndi opiates. Kuphatikiza apo, CBD ili ndi phindu lochepetsera ululu popanda zotsatira za psychotropic zokhudzana ndi THC kapena chamba. "
Mayesero achipatala a multicenter phase 1/2 adasankha anthu 99 mwachisawawa m'malo awiri owerengera (NYU Langone Health ndi Baptist Health/Jacksonville Orthopedic Institute) azaka zapakati pa 2 ndi 18 kukhala gulu la placebo ndi gulu lomwe limalandira CBD yoyamwa pakamwa. Ophunzira adapatsidwa mlingo wochepa wa Percocet, kulangizidwa kuti asiye mankhwala osokoneza bongo mwamsanga, ndi kutenga placebo / CBD katatu pa tsiku kwa masiku 75 pambuyo pa opaleshoni.
Patsiku loyamba atachitidwa opaleshoni, odwala omwe amalandila CBD amamva kupweteka pang'ono ndi 23 peresenti poyerekeza ndi kuchuluka kwa zowawa za analogi (VAS) poyerekeza ndi odwala omwe amalandila placebo. . Patsiku loyamba ndi lachiwiri pambuyo pa opaleshoni, odwala omwe amalandila CBD adanenanso kuti 22 mpaka 25% amakhutira kwambiri ndi kuwongolera ululu poyerekeza ndi omwe amalandila placebo. Kusanthula kwina kunawonetsanso kuti odwala omwe amalandila 50 mg wa CBD adanenanso zowawa pang'ono komanso kukhutitsidwa ndi kuwongolera kupweteka poyerekeza ndi odwala omwe amalandila placebo. Palibe zotsatira zazikulu zomwe zidanenedwa.
Ngakhale zotsatira zake zikulonjeza, Dr. Alaia anachenjeza ogula kuti asafunefune malonda a CBD. "Kafukufuku wathu akuwunika mankhwala opangidwa bwino, owunikidwa bwino pansi pa kafukufuku watsopano wamankhwala omwe avomerezedwa ndi FDA. Panopa akadali mankhwala oyesera ndipo sanapezeke kuti alembedwe, "akuwonjezera.
ORAVEXX, piritsi lomwe limagwiritsidwa ntchito mu kafukufukuyu, linapangidwa ndikupangidwa ndi Orcosa Inc., kampani ya sayansi ya moyo. Ndi gulu la CBD lomwe silimaledzera, lomwe limayamwa mwachangu lomwe limapangidwa kuti lizitha kupweteka.
Kupita patsogolo, NYU Langone yakhazikitsa kafukufuku wachiwiri akuyang'ana ngati ORAVEXX ikhoza kuchitira mwachindunji ululu wopweteka kwa odwala osteoarthritis. Maphunziro angapo a gawo 2 amakonzedwanso kuti awone momwe mankhwalawa amathandizira pazovuta zina zowopsa komanso zosatha komanso kuwunika momwe CBD imathandizira pa kutupa.
