Zatsopano Zatsopano Zochizira Mwachangu Polimbana ndi Ma cell Aakali a Khansa

Hoth Therapeutics, Inc. lero yalengeza zosintha zachitukuko cha buku lake lothandizira khansa, HT-KIT. Njira yatsopano ya Hoth, yomwe imagwiritsa ntchito oligonucleotide ya antisense yosasunthika kuti iwongolere pa proto-oncogene KIT kudzera mwakusintha zolemba za KIT mRNA, imatha kukhala ngati njira yochizira yomwe imayang'aniridwa ndi KIT yokha, kapena kuphatikiza ndi othandizira omwe amayang'ana kusaina kwa KIT, pochiza Matenda okhudzana ndi KIT.

Kupyolera mu mgwirizano wa kafukufuku wa sayansi wothandizidwa ndi yunivesite ya North Carolina State, gululo linagwiritsa ntchito njira yosinthira mawonekedwe a HT-KIT mRNA pa mast cell leukemia cell in vitro ndipo adapeza kuti KIT protein expression, signing and function idachepetsedwa. Kuchiza ndi HT-KIT kunalepheretsa kukula kwa maselo a khansa ndikupangitsa kufa kwa ma cell kwa maola 72. Muchitsanzo cha mbewa ya mast cell leukemia, kukula kwa chotupa ndi kulowa kwa ziwalo zina kunachepetsedwa ndipo kufa kwa cell chotupa kumawonjezeka pamene HT-KIT idapangitsa c-KIT mRNA.

Hoth wapereka ma patent angapo kuti ateteze IP iyi padziko lonse lapansi. 

"Ndi mankhwala athu a HT-KIT, tikuchotsa chizindikiro chachikulu cha khansa chomwe chimakhudzidwa ndi khansa zingapo zaukali, monga systemic mastocytosis, mast cell leukemia, zotupa zam'mimba komanso acute myeloid leukemia. Njira yathu imapewa misampha yokhudzana ndi kusintha kwa KIT poyang'ana mRNA. Gawo lathu lotsatira la maphunziro azachipatala likuchitika ndipo tili okondwa kugwiritsa ntchito zotsatira za msonkhano wathu wa Pre-IND ndi FDA kumapeto kwa chaka chino, "atero a Robb Knie, Chief Executive Officer wa Hoth.

HT-KIT, bungwe latsopano la molekyulu, adasankhidwa kukhala Orphan Drug pochiza mastocytosis koyambirira kwa 2022. HT-KIT Hoth yamaliza bwino kupanga kuthekera kwa mankhwala a HT-KIT mogwirizana ndi WuXi STA.

FDA Orphan Drug Designation imaperekedwa ku njira zofufuzira zochizira matenda osowa kapena mikhalidwe yomwe imakhudza anthu osakwana 200,000 ku United States. Kukhala ndi mankhwala kwa ana amasiye kumapereka zopindulitsa kwa opanga mankhwala, kuphatikizapo thandizo lachitukuko cha mankhwala, ziwongola dzanja zamisonkho pamitengo yachipatala, kukhululukidwa ku chindapusa china cha FDA ndi zaka zisanu ndi ziwiri zotsatiridwa ndi kutsatsa pambuyo pakuvomera.